Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIM23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TIM23 is a core component of the mitochondrial protein import machinery (TIM23 complex), essential for importing proteins into the mitochondrial inner membrane. It is critical for neuronal health and implicated in Parkinson's and Alzheimer's disease pathogenesis.
| Gene Symbol | TIM23 |
| Aliases | TIM23 complex |
| Function | Given the central role of mitochondria in neuronal function—particularly in high-energy demanding dopaminergic neurons and other neuronal subtypes—TIM23-mediated protein import is fundamental to ne... |
| Subcellular Localization | inner mitochondrial membrane |
| Molecular Weight | 16 kDa |
| Pathways | mitophagy |
| GeneCards | TIM23 |
| Human Protein Atlas | TIM23 |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Interactions | OPTINEURIN, HSP60, PINK1, NDP52 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
TIM23(["TIM23"])
OPTINEURIN(["OPTINEURIN"])
HSP60(["HSP60"])
mitophagy["mitophagy"]
Autophagy("Autophagy")
NDP52(["NDP52"])
TIM23 -->|"activates"| OPTINEURIN
TIM23 -->|"activates"| HSP60
TIM23 -->|"activates"| mitophagy
Autophagy -->|"activates"| TIM23
NDP52 -->|"activates"| TIM23
style TIM23 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| PINK1 | interacts_with | protein | 0.90 |
| OPTINEURIN | activates | protein | 0.50 |
| HSP60 | activates | protein | 0.50 |
| mitophagy | activates | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| mitochondrial membrane potential loss | inhibits | phenotype | 0.85 |
| Autophagy | activates | process | 0.50 |
| NDP52 | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||