protein

OPTINEURIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPTINEURIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1218Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

OPTINEURIN is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Alzheimer. Connected to 396 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	OPTINEURIN
Chromosome	10p13
Protein Family	Selective autophagy receptors (SQSTM1-like)
Protein Type	Adaptor Protein
Function	The UBAN domain recognizes ubiquitin chains on mitochondria, while the LIR motif recruits autophagosomes.
Molecular Weight	~67 kDa
Amino Acids	577
Pathways	Amyloid, Autophagy, Myelination, Necroptosis, Oxidative Stress
UniProt ID	Q96CV9
GeneCards	OPTINEURIN
Human Protein Atlas	OPTINEURIN
Associated Diseases	Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia
Interactions	ABCD3, ACTB, Actin, Akt, AKT1, AKT1S1
KG Connections	1215 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: OPTINEURIN — AlphaFold Q96CV9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Optineurin

protein · 2027 words

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Pathway Diagram

flowchart TD
    OPTINEURIN(["OPTINEURIN"])
    ULK1(["ULK1"])
    PINK1(["PINK1"])
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ALS["ALS"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    Cardiovascular["Cardiovascular"]
    Parkinson["Parkinson"]
    Fibrosis["Fibrosis"]
    Cancer["Cancer"]
    Tumor["Tumor"]

    OPTINEURIN -->|"recruits"| ULK1
    PINK1 -->|"recruits"| OPTINEURIN
    OPTINEURIN -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    OPTINEURIN -->|"interacts with"| ALS
    OPTINEURIN -->|"interacts with"| Dementia
    OPTINEURIN -->|"interacts with"| Alzheimer
    OPTINEURIN -->|"interacts with"| Frontotemporal_Dementia
    OPTINEURIN -->|"interacts with"| Cardiovascular
    OPTINEURIN -->|"interacts with"| Parkinson
    OPTINEURIN -->|"interacts with"| Fibrosis
    OPTINEURIN -->|"interacts with"| Cancer
    OPTINEURIN -->|"associated with"| Tumor
    OPTINEURIN -->|"associated with"| Parkinson
    OPTINEURIN -->|"associated with"| ALS
    OPTINEURIN -->|"associated with"| Frontotemporal_Dementia

    style OPTINEURIN fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (685)

Target	Relation	Type	Str
OPTINEURIN	encodes	protein	0.00
MITOPHAGY	mediates	process	0.90
ULK1	associated_with	protein	0.72
Frontotemporal Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Inflammation	inhibits	disease	0.65
Cardiovascular	activates	disease	0.65
ALS	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
Glaucoma	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Glaucoma	regulates	disease	0.65
Infection	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Aging	activates	disease	0.65
ALS	interacts_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Huntington	expressed_in	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Hypertension	activates	disease	0.65
Neuroinflammation	causes	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Ftd	causes	disease	0.65
Dementia	causes	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	causes	disease	0.65
Senescence	associated_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	degrades	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	causes	disease	0.65
Inflammation	causes	disease	0.65
ALS	regulates	disease	0.65
Spinocerebellar Ataxia	expressed_in	disease	0.65
Inflammation	degrades	disease	0.65
Ataxia	expressed_in	disease	0.65

Incoming (533)

Source	Relation	Type	Str
OPTINEURIN	encodes	gene	0.00
TBK1	binds	protein	0.90
TBK1	phosphorylates	protein	0.85
PINK1	associated_with	protein	0.72
MLKL	interacts_with	gene	0.60
PTEN	activates	gene	0.60
ATM	activates	entity	0.60
EIF2S1	activates	entity	0.60
LRRK2	activates	gene	0.60
RAB10	activates	gene	0.60
G3BP1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
OPTN	phosphorylates	gene	0.60
TBK1	phosphorylates	gene	0.60
P62	phosphorylates	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NFKB	associated_with	gene	0.60
ALS	activates	entity	0.60
FTD	activates	entity	0.60
AMPK	activates	entity	0.60
CANCER	phosphorylates	entity	0.60
DJ-1	activates	gene	0.60
GENES	activates	gene	0.60
AXON REGENERATION	activates	gene	0.60
AXONAL MITOCHONDRIAL TRANSPORT	activates	gene	0.60
MICROTUBULES	activates	gene	0.60
DISC1	activates	entity	0.60
DEMENTIA	associated_with	gene	0.60
MATR3	degrades	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
GSK3	associated_with	gene	0.60
P53	associated_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
GABARAPL2	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
TBK1	activates	gene	0.60
SQSTM1	phosphorylates	gene	0.60
DNM1L	activates	entity	0.60
GRB2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OPTINEURIN in their description or question text

No additional research found