protein

OPTINEURIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPTINEURIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1232Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

OPTINEURIN is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Alzheimer. Connected to 396 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	OPTINEURIN
Chromosome	10p13
Protein Family	Selective autophagy receptors (SQSTM1-like)
Protein Type	Adaptor Protein
Function	The UBAN domain recognizes ubiquitin chains on mitochondria, while the LIR motif recruits autophagosomes.
Subcellular Localization	Cytoplasm, Golgi apparatus, autophagosomes, mitochondrial contact sites
Molecular Weight	~67 kDa
Amino Acids	577
Pathways	Amyloid, Autophagy, Myelination, Necroptosis, Oxidative Stress
UniProt ID	Q96CV9
GeneCards	OPTINEURIN
Human Protein Atlas	OPTINEURIN
Gene	optn
Modification	Site
Phosphorylation	Ser513
Associated Diseases	ALS, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia
Interactions	TOLLIP, NDP52, BECN1, G3BP1, SMCR8, SNCAIP
KG Connections	1230 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: OPTINEURIN — AlphaFold Q96CV9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    OPTINEURIN(["OPTINEURIN"])
    ULK1(["ULK1"])
    PINK1(["PINK1"])
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ALS["ALS"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    Cardiovascular["Cardiovascular"]
    Parkinson["Parkinson"]
    Fibrosis["Fibrosis"]
    Cancer["Cancer"]
    Tumor["Tumor"]

    OPTINEURIN -->|"recruits"| ULK1
    PINK1 -->|"recruits"| OPTINEURIN
    OPTINEURIN -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    OPTINEURIN -->|"interacts with"| ALS
    OPTINEURIN -->|"interacts with"| Dementia
    OPTINEURIN -->|"interacts with"| Alzheimer
    OPTINEURIN -->|"interacts with"| Frontotemporal_Dementia
    OPTINEURIN -->|"interacts with"| Cardiovascular
    OPTINEURIN -->|"interacts with"| Parkinson
    OPTINEURIN -->|"interacts with"| Fibrosis
    OPTINEURIN -->|"interacts with"| Cancer
    OPTINEURIN -->|"associated with"| Tumor
    OPTINEURIN -->|"associated with"| Parkinson
    OPTINEURIN -->|"associated with"| ALS
    OPTINEURIN -->|"associated with"| Frontotemporal_Dementia

    style OPTINEURIN fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (695)

Target	Relation	Type	Str
MITOPHAGY	mediates	process	0.90
ULK1	recruits	protein	0.72
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	regulates	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Glaucoma	associated_with	disease	0.65
Hypertension	activates	disease	0.65
Als	activates	disease	0.65
Infection	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Ms	associated_with	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Huntington	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65
Inflammation	associated_with	disease	0.65
Parkinson	contributes_to	disease	0.65
Als	interacts_with	disease	0.65
Glaucoma	interacts_with	disease	0.65
Tumor	inhibits	disease	0.65
Ms	activates	disease	0.65
Ftd	causes	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Neuroinflammation	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65

Incoming (537)

Source	Relation	Type	Str
PINK1	recruits	protein	0.72
C9ORF72	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

OPTINEURIN

Understanding Entity Pages

Summary

Wiki Pages (21)

Optineurin

cbs-psp-daily-action-plan

neuroinflammation

Mitochondrial Quality Control

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Gene-Mechanism-Therapy Causal Chains

mitophagy-defect

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Lysosomal Dysfunction in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

Mitochondria in Neurodegeneration

pink1-parkin-mitophagy-pd-causal-chain

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

MYO6 — Myosin VI

ALS Biomarker-to-Mechanism Mapping

ALS RNA Metabolism and Proteostasis Failure

autophagy-lysosome-dysfunction