HSP60

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP60: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Hsp60 protein - mitochondrial chaperonin 60, protein folding, SPG13, neurodegeneration

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graph TD
    HSP60["<b>HSP60</b>"]
    Aging{"Aging"}
    HSP60 -->|"activates"| Aging
    Cardiovascular{"Cardiovascular"}
    HSP60 -->|"activates"| Cardiovascular
    PARKIN["PARKIN"]
    HSP60 -->|"activates"| PARKIN
    OPTINEURIN["OPTINEURIN"]
    HSP60 -->|"activates"| OPTINEURIN
    GRIA2["GRIA2"]
    HSP60 -->|"activates"| GRIA2
    PTEN["PTEN"]
    HSP60 -->|"activates"| PTEN
    LC3B["LC3B"]
    HSP60 -->|"activates"| LC3B
    COX4I1["COX4I1"]
    HSP60 -->|"activates"| COX4I1
    MITOCHONDRIA["MITOCHONDRIA"]
    HSP60 -->|"activates"| MITOCHONDRIA
    PINK1["PINK1"]
    HSP60 -->|"activates"| PINK1
    MAP1LC3B["MAP1LC3B"]
    HSP60 -->|"activates"| MAP1LC3B
    USP30["USP30"]
    HSP60 -->|"activates"| USP30
    XBP1["XBP1"]
    XBP1 -->|"activates"| HSP60
    MYO7A["MYO7A"]
    MYO7A -->|"activates"| HSP60
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| HSP60
    ATF3["ATF3"]
    ATF3 -->|"activates"| HSP60
    OPTN["OPTN"]
    OPTN -->|"activates"| HSP60
    PRKN["PRKN"]
    PRKN -->|"activates"| HSP60
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| HSP60
    HSPD1["HSPD1"]
    HSPD1 -->|"activates"| HSP60
    TOMM20["TOMM20"]
    TOMM20 -->|"activates"| HSP60
    FOXO3["FOXO3"]
    FOXO3 -->|"activates"| HSP60
    MAP1LC3B -->|"activates"| HSP60
    PTEN -->|"activates"| HSP60
    style HSP60 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0