Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TMEM16A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TMEM16A |
| Key Genes/Proteins | STROKE, PIEZO1, TRPA1 |
| Related Diseases | Alzheimer, Cardiovascular, Hypertension, Stroke |
| Related Pathways | contractility |
Knowledge base pages for this entity
graph TD
TMEM16A["TMEM16A"]
TMEM16A -->|"regulates"| Alzheimer["Alzheimer"]
TMEM16A -->|"regulates"| Cardiovascular["Cardiovascular"]
TMEM16A -->|"regulates"| Hypertension["Hypertension"]
TMEM16A -->|"regulates"| Stroke["Stroke"]
TMEM16A -->|"regulates"| STROKE["STROKE"]
TMEM16A -->|"regulates"| PIEZO1["PIEZO1"]
TMEM16A -->|"regulates"| Endothelial["Endothelial"]
TMEM16A -->|"regulates"| Neuron["Neuron"]
TRPV4["TRPV4"] -->|"regulates"| TMEM16A
ALZHEIMER["ALZHEIMER"] -->|"regulates"| TMEM16A
TRPA1["TRPA1"] -->|"regulates"| TMEM16A
AND["AND"] -->|"regulates"| TMEM16A
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| TMEM16A
STROKE -->|"regulates"| TMEM16A
PIEZO1 -->|"regulates"| TMEM16A| Target | Relation | Type | Str |
|---|---|---|---|
| Pericytes | expressed_in | cell_type | 0.85 |
| Pericyte Contractility | associated_with | process | 0.80 |
| Blood Flow Regulation | associated_with | process | 0.80 |
| Blood Flow Response | associated_with | process | 0.80 |
| blood flow responses | associated_with | process | 0.80 |
| contractility | regulates | biological_process | 0.80 |
| Alzheimer | regulates | disease | 0.65 |
| Cardiovascular | regulates | disease | 0.65 |
| Hypertension | regulates | disease | 0.65 |
| Stroke | regulates | disease | 0.65 |
| STROKE | regulates | gene | 0.60 |
| PIEZO1 | regulates | gene | 0.60 |
| Endothelial | regulates | cell_type | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| TRPA1 | regulates | gene | 0.60 |
| Pericyte | regulates | cell_type | 0.60 |
| TRPV4 | regulates | gene | 0.60 |
| pericytes | expressed_in | cell_type | 0.60 |
| Endothelial Cell | expressed_in | cell_type | 0.55 |
| Pericyte | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||