Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Pericyte: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Cell Type | Pericyte |
| Definition | Pericyte loss and dysfunction are critical drivers of blood-brain barrier (BBB) disruption and reduced cerebral blood flow in neurodegenerative diseases. Pericytes are contractile mural cells that ensheath cerebral capillaries, comprising approximately 80-95% of the capillary surface area in the hum |
| Key Markers | ABCC8, CD36, TNF, IFN, NFATC2, GLUT1, BACE1, VCAM1 |
| Key Pathways | Glycolysis, Pi3K/Akt, Blood-Brain Barrier, Mapk, Apoptosis |
| Associated Diseases | Alzheimer, Hypertension, Stroke, Als, Fibrosis, Cancer |
| Linked Hypotheses | 29 hypotheses |
Knowledge base pages for this entity
graph TD
Pericyte["Pericyte"] -->|"expressed in"| Spinal_Cord["Spinal Cord"]
style Spinal_Cord fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Pericyte["Pericyte"] -->|"expressed in"| Dentate_Gyrus["Dentate Gyrus"]
style Dentate_Gyrus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Pericyte["Pericyte"] -->|"expressed in"| White_Matter["White Matter"]
style White_Matter fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Pericyte["Pericyte"] -->|"expressed in"| Cortex["Cortex"]
style Cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
ABCC8["ABCC8"] -->|"expressed in"| Pericyte["Pericyte"]
style ABCC8 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
TRPV4["TRPV4"] -->|"regulates"| Pericyte["Pericyte"]
style TRPV4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
ALZHEIMER["ALZHEIMER"] -->|"regulates"| Pericyte["Pericyte"]
style ALZHEIMER fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
TMEM16A["TMEM16A"] -->|"regulates"| Pericyte["Pericyte"]
style TMEM16A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
STROKE["STROKE"] -->|"regulates"| Pericyte["Pericyte"]
style STROKE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style Pericyte fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Spinal Cord | expressed_in | brain_region | 0.50 |
| Dentate Gyrus | expressed_in | brain_region | 0.50 |
| White Matter | expressed_in | brain_region | 0.50 |
| Cortex | expressed_in | brain_region | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ABCC8 | expressed_in | gene | 0.80 |
| TRPV4 | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| TMEM16A | regulates | gene | 0.60 |
| STROKE | regulates | gene | 0.60 |
| TRPA1 | regulates | gene | 0.60 |
| PIEZO1 | regulates | gene | 0.60 |
| PERICYTE | interacts_with | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| ANGPT1 | interacts_with | gene | 0.60 |
| JUN | therapeutic_target | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| ALZHEIMER | causes | gene | 0.60 |
| DEMENTIA | contributes_to | gene | 0.60 |
| PERICYTE | activates | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| HUNTINGTON | contributes_to | gene | 0.60 |
| APOE4 | activates | gene | 0.60 |
| ALZHEIMER | biomarker_for | gene | 0.60 |
| NFL | biomarker_for | gene | 0.60 |
| DEMENTIA | biomarker_for | gene | 0.60 |
| MICROGLIA | biomarker_for | gene | 0.60 |
| UCHL1 | biomarker_for | gene | 0.60 |
| UBIQUITIN | biomarker_for | gene | 0.60 |
| GFAP | biomarker_for | gene | 0.60 |
| PARKINSON | biomarker_for | gene | 0.60 |
| ASTROCYTES | biomarker_for | gene | 0.60 |
| TMEM119 | biomarker_for | gene | 0.60 |
| OVERVIEW | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| STROKE | activates | gene | 0.60 |
| MITOCHONDRIA | regulates | gene | 0.60 |
| DEMENTIA | regulates | gene | 0.60 |
| MICROGLIA | regulates | gene | 0.60 |
| HUNTINGTON | regulates | gene | 0.60 |
| PER | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| ALS | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| SMAD3 | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| VEGFA | activates | gene | 0.60 |
| MAPK | contributes_to | gene | 0.60 |
| APOPTOSIS | contributes_to | gene | 0.60 |
| CYTOKINES | contributes_to | gene | 0.60 |
| MICRORNAS | contributes_to | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Pericyte Contractility Reset via Selective PDGFR-β Agonism | 0.443 | neurodegeneration | Perivascular spaces and glymphatic clear |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726] | Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu | Cell Stem Cell | 2025 | 1 |
| Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043] | Kempuraj D, Dourvetakis KD, Cohen J, Val | Front Cell Neurosci | 2024 | 1 |
| The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066] | Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T | Int J Mol Sci | 2023 | 1 |
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 1 |
| Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333] | Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z | Nature | 2021 | 1 |
| APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954] | Montagne A, Nation DA, Sagare AP, Barisa | Nature | 2020 | 1 |
| Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990] | Keller A | Annual review of physiology | 2026 | 0 |
| A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033] | Levey J, Howe M, Douglas K, Odame E, Raj | bioRxiv : the preprint server | 2026 | 0 |
| Immunological mechanisms and therapeutic approaches in pulmonary fibrosis. [PMID:41951242] | Nell LM, Hendriks RW, Wijsenbeek MS, Cor | Eur Respir Rev | 2026 | 0 |
| Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335] | Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha | Research (Washington, D.C.) | 2026 | 0 |
| Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129] | Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu | Clinical & experimental ophtha | 2026 | 0 |
| Central nervous system pericytes express soluble ST2 in inflammation and injury. [PMID:41857656] | Jansson D, Highet B, Li S, Stevenson TJ, | Molecular brain | 2026 | 0 |
| Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235] | Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn | Pathology international | 2026 | 0 |
| The role of endothelial cell-pericyte interactions in vascularization and diseas [PMID:38246244] | Li G, Gao J, Ding P, Gao Y | Journal of advanced research | 2025 | 0 |
| Pericytes in Brain Homeostasis: Developmental Roles and Adult Functions. [PMID:41351407] | Drozd U, Vechkapova S, Lanshakov D | Frontiers in bioscience (Landm | 2025 | 0 |
| Pericyte-derived fibrotic scarring is conserved across diverse central nervous s [PMID:34535655] | Dias DO, Kalkitsas J, Kelahmetoglu Y, Es | Nature communications | 2021 | 0 |
| Blood-brain barrier breakdown is an early biomarker of human cognitive dysfuncti [PMID:30643288] | Nation DA, Sweeney MD, Montagne A, Sagar | Nature medicine | 2019 | 0 |
| Pericytes in Primary Familial Brain Calcification. [PMID:31147881] | Zarb Y, Franzoso FD, Keller A | Advances in experimental medic | 2019 | 0 |
| Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. [PMID:29502968] | Dias DO, Kim H, Holl D, Werne Solnestam | Cell | 2018 | 0 |
| Clarifying off-target effects for torcetrapib using network pharmacology and rev [PMID:23228038] | ["Fan S", "Geng Q", "Pan Z", "Li X", "Ti | BMC systems biology | 2012 | 0 |