gene

TRPV4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPV4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

306Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

TRPV4 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, causes. Associated with ALS, Aging, Als. Connected to 131 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	TRPV4
Full Name	Transient Receptor Potential Cation Channel Subfamily V Member 4
Chromosome	12q24.11
Protein Type	Channel
Function	of 871 amino acids with a molecular weight of approximately 98 kDa
Primary Expression	Cerebral cortex, Hippocampus, Dorsal root ganglion, Peripheral nerves, Endothelial cells
Molecular Weight	98 kDa
Amino Acids	871 aa
Exons	15
Pathways	Akt, Angiogenesis, Blood-Brain Barrier, Er Stress, Mitophagy
UniProt ID	Q9HBA0
NCBI Gene ID	59341
Ensembl ID	ENSG00000167799
OMIM	605067
GeneCards	TRPV4
Human Protein Atlas	TRPV4
Associated Diseases	ALS, Aging, Alzheimer, Blood-CNS Barrier Disruption, Cancer
Known Drugs/Compounds	CBD, cannabidiol
Interactions	FSP1, KCNK2, PIEZO1, MTOR, AKT, Mechanosensitive Ion Channel
KG Connections	306 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRPV4 — AlphaFold Q9HBA0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRPV4["TRPV4"]
    TRPV4 -->|"regulates"| mitophagy["mitophagy"]
    TRPV4 -.biomarker for.-> glioma["glioma"]
    TRPV4 -->|"activates"| Hypertension["Hypertension"]
    TRPV4 -->|"target for"| Cancer["Cancer"]
    TRPV4 -->|"activates"| Tumor["Tumor"]
    TRPV4 -->|"target for"| Als["Als"]
    TRPV4 -->|"regulates"| Stroke["Stroke"]
    TRPV4 -->|"regulates"| Alzheimer["Alzheimer"]
    CBD["CBD"] -->|"activates"| TRPV4
    cannabidiol["cannabidiol"] -->|"activates"| TRPV4
    PIEZO1["PIEZO1"] -->|"expressed in"| TRPV4
    KCNK2["KCNK2"] -->|"activates"| TRPV4
    TRPC1["TRPC1"] -->|"activates"| TRPV4
    CACNA1C["CACNA1C"] -->|"expressed in"| TRPV4
    GENES["GENES"] -->|"activates"| TRPV4
    FSP1["FSP1"] -->|"activates"| TRPV4

Outgoing (184)

Target	Relation	Type	Str
Blood-CNS Barrier Disruption	causes	phenotype	0.95
Motor Neuron Degeneration	causes	disease	0.95
Blood-Cns Barrier Disruption	causes	process	0.95
Hereditary Motor Neuron Disease	associated_with	disease	0.92
Neurovascular Coupling	contributes_to	process	0.90
Brain Capillary Endothelial Cell	expressed_in	cell_type	0.90
calcium dynamics	regulates	phenotype	0.90
Calcium Dynamics	regulates	biological_process	0.90
Blood Flow Regulation	modulates	process	0.85
Blood Flow	modulates	phenotype	0.85
Membrane Potential	regulates	phenotype	0.85
mechanotransduction	mediates	pathway	0.85
Blood-CNS Barrier Breakdown	causes	biological_process	0.80
TNF-α	upregulates	protein	0.80
Ovarian Cancer	associated_with	disease	0.80
Ovarian Cancer	biomarker_for	disease	0.80
Mechanosensitive Ion Channel	interacts_with	protein	0.75
Tumor	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Psoriasis	activates	disease	0.75
glioma	biomarker_for	disease	0.70
mitophagy	regulates	process	0.70
mitophagy	activates	process	0.70
Cancer	associated_with	disease	0.65
Hypertension	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Hypertension	regulates	disease	0.65
Stroke	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Hypertension	contributes_to	disease	0.65
Stroke	contributes_to	disease	0.65
Aging	associated_with	disease	0.65
ALS	activates	disease	0.65
Cancer	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	associated_with	disease	0.65
Glioma	activates	disease	0.65
Als	implicated_in	disease	0.65
Inflammation	contributes_to	disease	0.65
Parkinson	contributes_to	disease	0.65
Ms	causes	disease	0.65
Als	causes	disease	0.65
ALS	causes	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Als	inhibits	disease	0.65
Multiple Sclerosis	activates	disease	0.65

Incoming (122)

Source	Relation	Type	Str
Frostbite Injury	upregulates	disease	0.90
R269C Mutation	associated_with	biomarker	0.85
R232C Mutation	associated_with	biomarker	0.85
ECM stiffness	activates	phenotype	0.85
Ecm Stiffness	activates	pathway	0.80
CBD	activates	drug	0.70
cannabidiol	activates	drug	0.70
PIEZO1	expressed_in	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
PIEZO1	activates	gene	0.60
KCNK2	activates	gene	0.60
TRPC1	activates	gene	0.60
PIEZO1	regulates	gene	0.60
CACNA1B	associated_with	gene	0.60
CACNA1C	expressed_in	gene	0.60
CFTR	associated_with	gene	0.60
FSP1	activates	gene	0.60
TRPA1	regulates	gene	0.60
AQP4	expressed_in	gene	0.60
KCNMA1	causes	gene	0.60
KCNQ1	causes	gene	0.60
CFTR	causes	gene	0.60
SCN1A	causes	gene	0.60
TRPA1	causes	gene	0.60
KCNN4	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
KCNK2	causes	gene	0.60
TRPA1	activates	gene	0.60
TNF	activates	gene	0.60
ATF4	activates	gene	0.60
DDIT3	activates	gene	0.60
AKT	activates	gene	0.60
HDAC6	inhibits	gene	0.60
CACNA1C	associated_with	entity	0.60
KCNMA1	associated_with	entity	0.60
KCNN4	associated_with	entity	0.60
KCNQ1	associated_with	entity	0.60
PIEZO1	associated_with	entity	0.60
PIEZO2	associated_with	entity	0.60
SCNN1A	associated_with	entity	0.60
TRPA1	associated_with	entity	0.60
TRPV1	associated_with	entity	0.60
FSP1	inhibits	entity	0.60
KCNK2	inhibits	entity	0.60
PIEZO1	inhibits	entity	0.60
TRPC1	inhibits	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TRPV4

Understanding Entity Pages

Summary

Wiki Pages (21)

TRPV4 Gene

blood-brain-barrier

Charcot-Marie-Tooth Disease

Perivascular Space Drainage Enhancement Therapy

Focused Ultrasound-Enhanced Nanoparticle Delivery

Spinal Dorsal Horn Lamina I Projection Neurons

Ion Channel Dysfunction in 4R-Tauopathies

TRPV2 — Transient Receptor Potential Cation Channel Subfamily V Member 2

KCNMA1 Gene

Pituicytes

Trigeminal Mesencephalic Nucleus

Substantia Nigra Neurons in Corticobasal Degeneration

PIEZO2 — Piezo Type Mechanosensitive Ion Channel Component 2

Sonogenetics

Thermoreceptors

SCN1A Gene

C19orf12 Protein

Cav1.2 - Voltage-Gated L-Type Calcium Channel (CACNA1C)

Choroid Plexus Epithelium

Organum Vasculosum Neurons