gene

TRPA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

254Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TRPA1 encodes a non-selective cation channel activated by oxidative stress, irritants, and inflammatory mediators. Implicated in neuropathic pain, neuroinflammation, and neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	TRPA1
Aliases	ANKTM1
Chromosome	8q21.11
Protein Type	Protein
Function	is a calcium-permeable non-selective cation channel characterized by 16-18 ankyrin repeat domains in its N-terminus, making it the most ankyrin-rich TRP channel[@nilius2014].
Primary Expression	Sensory neurons, CNS neurons, glia, airway epithelium, GI tract
Molecular Weight	~108 kDa
Amino Acids	959 aa
Pathways	Epigenetic, Nf-Κb, Toll-Like Receptor
UniProt ID	Q8IUM7
NCBI Gene ID	8980
GeneCards	TRPA1
Human Protein Atlas	TRPA1
Protein Length	959 amino acids
Protein Class	Non-selective calcium-permeable cation channel
Associated Diseases	Alzheimer, Cancer, stroke
Interactions	SRC, SCN8A, AKT1, TRPM3, CREBBP, TNF
KG Connections	254 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRPA1 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRPA1["TRPA1 Channel"] -->|"Senses"| Oxidative["Oxidative Stress"]
    TRPA1 -->|"Activated by"| Irritants["Irritants and Inflammatory Mediators"]
    TRPA1 -->|"Permits"| CaInflux["Ca2+ Influx"]
    CaInflux -->|"Activates"| NF_kB["NF-kappaB Pathway"]
    NF_kB -->|"Induces"| CCL3["CCL3 Chemokine"]
    NF_kB -->|"Induces"| CXCL2["CXCL2 Chemokine"]
    TRPA1 -->|"Regulates"| CHRNA7["CHRNA7 Receptor"]
    TRPA1 -->|"Modulates"| FOXP3["FOXP3 / T-reg Response"]
    CaInflux -->|"Triggers"| Neuroinflammation["Neuroinflammation"]
    Neuroinflammation -.Contributes to.-> AD["Alzheimer's Disease"]
    TRPA1 -.Implicated in.-> Pain["Neuropathic Pain"]

Outgoing (155)

Target	Relation	Type	Str
MECHANOTRANSDUCTION	involved_in	entity	0.90
Periodontal Ligament Cells	expressed_in	cell_type	0.85
Periodontal Ligament Cell	expressed_in	cell_type	0.85
orthodontic tooth movement	involved_in	process	0.85
Blood Flow	modulates	phenotype	0.85
Brain Capillary Endothelial Cells	expressed_in	cell_type	0.80
Neurovascular Coupling	contributes_to	process	0.80
Calcium Dynamics	regulates	process	0.80
Inflammation	activates	disease	0.75
INFLAMMATION	activates	gene	0.70
Cancer	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Hypertension	regulates	disease	0.65
Stroke	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Hypertension	contributes_to	disease	0.65
Stroke	contributes_to	disease	0.65
Ms	inhibits	disease	0.65
Migraine	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Psoriasis	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
KCNMA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
TRPM8	expressed_in	gene	0.60
TRPM7	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
PIEZO1	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
PIEZO1	expressed_in	gene	0.60
KCNK2	expressed_in	gene	0.60
PIEZO1	regulates	gene	0.60
TRPV4	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60

Incoming (99)

Source	Relation	Type	Str
TNF-α	upregulates	protein	0.95
TNF	modulates	entity	0.90
Frostbite Injury	upregulates	disease	0.90
TNF	upregulates	entity	0.85
TNF-Α	upregulates	protein	0.85
TNF-Α	modulates	protein	0.80
TNFA	activates	protein	0.64
PIEZO1	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
PIEZO1	expressed_in	gene	0.60
KCNK2	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
PIEZO1	regulates	gene	0.60
TRPV4	regulates	gene	0.60
CACNA1C	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
KCNMA1	causes	gene	0.60
KCNQ1	causes	gene	0.60
PIEZO1	causes	gene	0.60
CFTR	causes	gene	0.60
SCN1A	causes	gene	0.60
KCNK2	causes	gene	0.60
TRPV4	causes	gene	0.60
CACNA1B	causes	gene	0.60
CACNA1C	causes	gene	0.60
KCNN4	causes	gene	0.60
TRPM7	causes	gene	0.60
TRPM8	expressed_in	gene	0.60
APP	inhibits	gene	0.60
ANG	regulates	gene	0.60
KCNMA1	associated_with	entity	0.60
KCNN4	associated_with	entity	0.60
TRPV1	causes	gene	0.60
IL10	activates	gene	0.60
IL1B	activates	gene	0.60
NOD2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TRPA1

Understanding Entity Pages

Summary

Wiki Pages (21)

TRPA1 Gene

iron-calcium-glymphatic-convergence-alzheimers

Ion Channel Dysfunction in ALS

Spinal Cord Lamina I Pain Neurons

Gasotransmitters in Neuroprotection - AD/PD

IL31 (Interleukin 31)

Hydrogen Sulfide Signaling Pathway in Neurodegeneration

Pacinian Corpuscles

Spinal Dorsal Horn Lamina I Projection Neurons

Innate Immune Response in Neurodegeneration

Area Postrema Neurons in Chemotherapy-Induced Nausea

KCNMA1 Gene

TRPM3 Gene - Transient Receptor Potential Channel

Disease-Associated Astrocytes (DAA)

Spinothalamic Tract Fibers

Calcium Channel Dysfunction in Neurodegeneration

Trigeminal Mesencephalic Nucleus

Interpeduncular Nucleus GABAergic Neurons

Principal Sensory Trigeminal Nucleus Neurons