gene

TRPA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

257Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

18Debates

Summary

TRPA1 encodes a non-selective cation channel activated by oxidative stress, irritants, and inflammatory mediators. Implicated in neuropathic pain, neuroinflammation, and neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	TRPA1
Protein Type	Protein
Function	is a calcium-permeable non-selective cation channel characterized by 16-18 ankyrin repeat domains in its N-terminus, making it the most ankyrin-rich TRP channel[@nilius2014].
Molecular Weight	108 kDa
Amino Acids	959 aa
Pathways	Epigenetic, Nf-Κb, Toll-Like Receptor
UniProt ID	Search UniProt
GeneCards	TRPA1
Human Protein Atlas	TRPA1
Associated Diseases	Alzheimer, Cancer, stroke
Interactions	AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APP
KG Connections	257 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TRPA1 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRPA1["TRPA1 Channel"] -->|"Senses"| Oxidative["Oxidative Stress"]
    TRPA1 -->|"Activated by"| Irritants["Irritants and Inflammatory Mediators"]
    TRPA1 -->|"Permits"| CaInflux["Ca2+ Influx"]
    CaInflux -->|"Activates"| NF_kB["NF-kappaB Pathway"]
    NF_kB -->|"Induces"| CCL3["CCL3 Chemokine"]
    NF_kB -->|"Induces"| CXCL2["CXCL2 Chemokine"]
    TRPA1 -->|"Regulates"| CHRNA7["CHRNA7 Receptor"]
    TRPA1 -->|"Modulates"| FOXP3["FOXP3 / T-reg Response"]
    CaInflux -->|"Triggers"| Neuroinflammation["Neuroinflammation"]
    Neuroinflammation -.Contributes to.-> AD["Alzheimer's Disease"]
    TRPA1 -.Implicated in.-> Pain["Neuropathic Pain"]

Outgoing (155)

Target	Relation	Type	Str
neuronal populations	expressed_in	cell_type	0.90
inflammatory pain	contributes_to	unknown	0.90
MECHANOTRANSDUCTION	involved_in	entity	0.90
Periodontal Ligament Cell	expressed_in	cell_type	0.85
Periodontal Ligament Cells	expressed_in	cell_type	0.85
orthodontic tooth movement	involved_in	process	0.85
Blood Flow	modulates	phenotype	0.85
Calcium Dynamics	regulates	process	0.80
Neurovascular Coupling	contributes_to	process	0.80
Brain Capillary Endothelial Cells	expressed_in	cell_type	0.80
Inflammation	activates	disease	0.75
INFLAMMATION	activates	gene	0.70
Inflammation	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Psoriasis	activates	disease	0.65
Migraine	inhibits	disease	0.65
Ms	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Stroke	contributes_to	disease	0.65
Alzheimer	inhibits	disease	0.65
Cardiovascular	regulates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Hypertension	contributes_to	disease	0.65
Hypertension	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Stroke	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
HMOX1	regulates	gene	0.60
STAT3	regulates	gene	0.60
KCNK2	expressed_in	gene	0.60
SYT1	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
PIEZO1	expressed_in	gene	0.60
TRPM7	associated_with	gene	0.60
SYP	regulates	gene	0.60
RELA	regulates	gene	0.60
KCNK2	associated_with	gene	0.60
P2RX3	regulates	gene	0.60
NOS2	regulates	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPM8	expressed_in	gene	0.60
KCNN4	associated_with	gene	0.60
SCNN1A	causes	gene	0.60
TRPV1	causes	gene	0.60
KCNK2	causes	gene	0.60
TRPV4	causes	gene	0.60

Incoming (102)

Source	Relation	Type	Str
GPR32	mediates	protein	0.95
Resolvin D1	inhibits	unknown	0.95
TNF-α	upregulates	protein	0.95
Resolvin D2	inhibits	unknown	0.95
Frostbite Injury	upregulates	disease	0.90
TNF	modulates	entity	0.90
TNF	upregulates	entity	0.85
TNF-Α	upregulates	protein	0.85
TNF-Α	modulates	protein	0.80
TNFA	activates	protein	0.64
TRPV4	associated_with	gene	0.60
KCNK2	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
PIEZO1	regulates	gene	0.60
TNF	activates	gene	0.60
TRPV1	activates	gene	0.60
SCN5A	causes	gene	0.60
IL10	activates	gene	0.60
TRPM7	associated_with	gene	0.60
S100B	regulates	gene	0.60
PIEZO1	associated_with	gene	0.60
CASP3	regulates	gene	0.60
SCN1A	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
KCNQ1	causes	gene	0.60
PIEZO1	causes	gene	0.60
CFTR	causes	gene	0.60
SCN1A	causes	gene	0.60
KCNK2	causes	gene	0.60
TRPV4	causes	gene	0.60
SCN5A	associated_with	gene	0.60
IL1B	activates	gene	0.60
PANX1	regulates	gene	0.60
APP	inhibits	gene	0.60
TRPM8	expressed_in	gene	0.60
KCNQ1	associated_with	gene	0.60
ANG	regulates	gene	0.60
SCNN1A	associated_with	gene	0.60
KCNMA1	associated_with	entity	0.60
KCNN4	associated_with	entity	0.60
RELB	regulates	gene	0.60
CFTR	associated_with	gene	0.60
P2RY1	regulates	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPM7	causes	gene	0.60
TRPV1	causes	gene	0.60
SOCS3	regulates	gene	0.60
PIEZO1	expressed_in	gene	0.60
KCNMA1	causes	gene	0.60
KCNN4	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (18)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning TRPA1 in their description or question text

No additional research found

TRPA1

Understanding Entity Pages

Summary

Wiki Pages (3)

TRPA1 Gene

TRPA1 Protein

TRPA1 Protein

Pathway Diagram

Outgoing (155)

Incoming (102)

Targeting Hypotheses (0)

Mentioning Analyses (1)

Circuit-level neural dynamics in neurodegeneration

Experiments (0)

Related Papers (0)

Debates (18)

Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent

Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau

Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte

Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati

Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma

Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin

Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de

Debate: Closed-loop transcranial focused ultrasound with real-time gamma feedbac

Hypothesis debate: Closed-loop transcranial alternating current stimulation to r

Hypothesis debate: Closed-loop transcranial focused ultrasound to restore hippoc

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