protein

TNFPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Incoming

0Experiments

Summary

Tumor necrosis factor alpha (TNF-α) is a potent pro-inflammatory cytokine that plays a central role in immune regulation, inflammation, and cell survival.

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🔬 Protein Info

Gene Symbol	TNF
Full Name	Tumor Necrosis Factor
Aliases	TNF-α
Chromosome	6p21.33
Protein Family	TNF Superfamily
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	immune cells and endothelial cells](/cell-types/endothelial-cells) - Activates NF-κB and MAPK pathways - [Predominantly pro-survival sign
Molecular Weight	25.6 kDa (monomer), 52.4 kDa (trimer)
Exons	3
Pathways	NF-κB signaling, NF-κB, MAPK, PI3K
UniProt ID	P01375
NCBI Gene ID	7124
Ensembl ID	ENSG00000232890
GeneCards	TNF
Human Protein Atlas	TNF
Associated Diseases	AD, ALS, AMI, Aging, Alopecia Areata
Known Drugs/Compounds	ETANERCEPT, RAPAMYCIN, NAC, METFORMIN, SELEGILINE, quercetin
Interactions	MIR193B5P, OCLN, LMNA, APH1B, APOE, IL6
KG Connections	5559 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFPROTEIN — AlphaFold P01375 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TNF Alpha Protein

protein · 1063 words

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Pathway Diagram

graph TD
    TNFPROTEIN["TNFPROTEIN"]
    neurodegeneration["neurodegeneration"]
    TNFPROTEIN -->|"implicated_in"| neurodegeneration
    style TNFPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found