disease

Fatty Liver

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Fatty Liver: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

483Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

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Disease Info

Associated Genes	AGING, AKT, APOPTOSIS, AUTOPHAGY, CANCER, DIABETES MELLITUS, EXERCISE, GAIN
KG Connections	477 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    Fatty_Liver["Fatty Liver"]
    Lipid_Metabolism["Lipid Metabolism"]
    Fatty_Liver -->|"activates"| Lipid_Metabolism
    Metastatic_Tumor_Microenvironm["Metastatic Tumor Microenvironment"]
    Fatty_Liver -->|"contributes_to"| Metastatic_Tumor_Microenvironm
    Autophagy["Autophagy"]
    Fatty_Liver -->|"activates"| Autophagy
    Tumor_Metastasis["Tumor Metastasis"]
    Fatty_Liver -->|"risk_factor_for"| Tumor_Metastasis
    INSULIN_RESISTANCE(["INSULIN RESISTANCE"])
    INSULIN_RESISTANCE -->|"activates"| Fatty_Liver
    Als{"Als"}
    Als -->|"therapeutic_target"| Fatty_Liver
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"therapeutic_target"| Fatty_Liver
    style Fatty_Liver fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (107)

Target	Relation	Type	Str
Lipid Metabolism	activates	pathway	1.00
Lipid Metabolism	regulates	pathway	1.00
extracellular vesicles	promotes	process	0.95
Metastatic Tumor Microenvironment	contributes_to	phenotype	0.90
Autophagy	regulates	pathway	0.90
Autophagy	activates	pathway	0.90
metastasis	promotes	process	0.88
Obesity	activates	disease	0.85
cancer risk	risk_factor_for	phenotype	0.85
Obesity	associated_with	disease	0.85
Insulin Resistance	therapeutic_target	disease	0.85
Tumor Metastasis	risk_factor_for	process	0.85
Lipid Metabolism	therapeutic_target	pathway	0.80
Mtor	therapeutic_target	pathway	0.80
Mtor	activates	pathway	0.80
Cholesterol	inhibits	pathway	0.80
Lipid Metabolism	associated_with	pathway	0.80
Autophagy	implicated_in	pathway	0.80
Autophagy	therapeutic_target	pathway	0.80
Type 2 Diabetes	activates	disease	0.75
Oxidative Stress	activates	pathway	0.70
Lipid Metabolism	causes	pathway	0.70
Oxidative Stress	regulates	pathway	0.70
Chaperone	regulates	pathway	0.70
Lipid Metabolism	inhibits	pathway	0.70
Cholesterol	therapeutic_target	pathway	0.70
Cholesterol	regulates	pathway	0.70
Mitophagy	therapeutic_target	pathway	0.70
Nf-Κb	activates	pathway	0.70
Insulin Resistance	activates	disease	0.65
Obesity	therapeutic_target	disease	0.65
Type 2 Diabetes	regulates	disease	0.65
Obesity	regulates	disease	0.65
Insulin Resistance	regulates	disease	0.65
Oxidative Stress	inhibits	pathway	0.60
Mitochondrial Function	inhibits	pathway	0.60
Apoptosis	implicated_in	pathway	0.60
Proteasome	regulates	pathway	0.60
Ferroptosis	therapeutic_target	pathway	0.60
Autophagy	contributes_to	pathway	0.60
Calcium Signaling	activates	pathway	0.60
Oxidative Stress	causes	pathway	0.60
Inflammasome	implicated_in	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Cholesterol	causes	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Erk Signaling	regulates	pathway	0.60
Ppar Signaling	activates	pathway	0.60
Mitochondrial Function	activates	pathway	0.60

Incoming (376)

Source	Relation	Type	Str
Als	therapeutic_target	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
Als	activates	disease	1.00
INSULIN RESISTANCE	activates	gene	1.00
Nafld	associated_with	disease	1.00
Als	regulates	disease	0.95
AUTOPHAGY	regulates	gene	0.95
INSULIN RESISTANCE	therapeutic_target	gene	0.95
Inflammation	therapeutic_target	disease	0.95
Diabetes	activates	disease	0.95
Extracellular Vesicles	associated_with	process	0.95
INFLAMMATION	causes	gene	0.95
AUTOPHAGY	activates	gene	0.95
Extracellular Vesicles	expressed_in	cell_type	0.95
CANCER	therapeutic_target	gene	0.85
INFLAMMATION	activates	gene	0.85
AUTOPHAGY	implicated_in	gene	0.85
AUTOPHAGY	therapeutic_target	gene	0.85
Nafld	therapeutic_target	disease	0.85
Inflammation	causes	disease	0.85
DIABETES MELLITUS	causes	gene	0.85
MTORC1	therapeutic_target	gene	0.85
MTOR	therapeutic_target	gene	0.85
Nafld	treats	disease	0.85
PPAR	activates	gene	0.85
LIPOPHAGY	activates	gene	0.85
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.75
Insulin Resistance	activates	disease	0.75
CANCER	causes	gene	0.75
SIRT1	activates	gene	0.75
Aging	activates	disease	0.75
LIPOPHAGY	regulates	gene	0.75
NF-ΚB	activates	gene	0.75
Hepatocellular Carcinoma	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Hepatitis	associated_with	disease	0.75
LDL	activates	gene	0.75
Cancer	therapeutic_target	disease	0.75
MITOCHONDRIA	inhibits	gene	0.75
TFEB	regulates	gene	0.75
CYTOKINES	activates	gene	0.75
Obesity	activates	disease	0.75
LIPOPHAGY	associated_with	gene	0.75
Diabetes	causes	disease	0.75
INSULIN RESISTANCE	inhibits	gene	0.75
INSULIN RESISTANCE	associated_with	gene	0.75
Metabolic Syndrome	regulates	disease	0.75
P62	regulates	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
Hepatitis	activates	disease	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying epigenetic clocks and biological aging in neu

closed · Rounds: 4 · Score: 0.88 · 2026-04-01

Related Research

Hypotheses and analyses mentioning Fatty Liver in their description or question text

No additional research found