SciDEX — Fatty Liver

graph TD
    Fatty_Liver["<b>Fatty Liver</b>"]
    Lipid_Metabolism["Lipid Metabolism"]
    Fatty_Liver -->|"activates"| Lipid_Metabolism
    Metastatic_Tumor_Microenvironm["Metastatic Tumor Microenvironment"]
    Fatty_Liver -->|"contributes_to"| Metastatic_Tumor_Microenvironm
    Autophagy["Autophagy"]
    Fatty_Liver -->|"activates"| Autophagy
    Tumor_Metastasis["Tumor Metastasis"]
    Fatty_Liver -->|"risk_factor_for"| Tumor_Metastasis
    INSULIN_RESISTANCE(["INSULIN RESISTANCE"])
    INSULIN_RESISTANCE -->|"activates"| Fatty_Liver
    Als{"Als"}
    Als -->|"therapeutic_target"| Fatty_Liver
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"therapeutic_target"| Fatty_Liver
    style Fatty_Liver fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (110)

Target	Relation	Type	Str
Lipid Metabolism	activates	pathway	1.00
Lipid Metabolism	regulates	pathway	1.00
Metastatic Tumor Microenvironment	contributes_to	phenotype	0.90
Autophagy	activates	pathway	0.90
Autophagy	regulates	pathway	0.90
Tumor Metastasis	risk_factor_for	process	0.85
Insulin Resistance	therapeutic_target	disease	0.85
Obesity	activates	disease	0.85
Obesity	associated_with	disease	0.85
Lipid Metabolism	implicated_in	pathway	0.80
Cholesterol	inhibits	pathway	0.80
Autophagy	implicated_in	pathway	0.80
Mtor	therapeutic_target	pathway	0.80
Autophagy	therapeutic_target	pathway	0.80
Lipid Metabolism	therapeutic_target	pathway	0.80
Mtor	activates	pathway	0.80
Type 2 Diabetes	activates	disease	0.75
Cholesterol	therapeutic_target	pathway	0.70
Lipid Metabolism	causes	pathway	0.70
Cholesterol	regulates	pathway	0.70
Chaperone	regulates	pathway	0.70
Mitophagy	therapeutic_target	pathway	0.70
Nf-Κb	activates	pathway	0.70
Oxidative Stress	regulates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Lipid Metabolism	inhibits	pathway	0.70
Obesity	therapeutic_target	disease	0.65
Obesity	regulates	disease	0.65
Type 2 Diabetes	regulates	disease	0.65
Insulin Resistance	regulates	disease	0.65
Insulin Resistance	activates	disease	0.65
Mtor	inhibits	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
Microbiota	regulates	pathway	0.60
Senescence	regulates	pathway	0.60
Inflammasome	regulates	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Oxidative Stress	causes	pathway	0.60
Cholesterol	causes	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
Er Stress	activates	pathway	0.60
Autophagy	inhibits	pathway	0.60
Er Stress	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Ampk Signaling	activates	pathway	0.60
Apoptosis	implicated_in	pathway	0.60
Inflammasome	implicated_in	pathway	0.60

Incoming (386)

Source	Relation	Type	Str
INSULIN RESISTANCE	activates	gene	1.00
Als	therapeutic_target	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
Als	activates	disease	1.00
Nafld	associated_with	disease	1.00
Extracellular Vesicles	associated_with	process	0.95
AUTOPHAGY	activates	gene	0.95
INSULIN RESISTANCE	therapeutic_target	gene	0.95
AUTOPHAGY	regulates	gene	0.95
Inflammation	therapeutic_target	disease	0.95
INFLAMMATION	causes	gene	0.95
Diabetes	activates	disease	0.95
Als	regulates	disease	0.95
Extracellular Vesicles	expressed_in	cell_type	0.95
CANCER	therapeutic_target	gene	0.85
AUTOPHAGY	implicated_in	gene	0.85
Nafld	therapeutic_target	disease	0.85
DIABETES MELLITUS	causes	gene	0.85
MTORC1	therapeutic_target	gene	0.85
MTOR	therapeutic_target	gene	0.85
Inflammation	causes	disease	0.85
INFLAMMATION	activates	gene	0.85
AUTOPHAGY	therapeutic_target	gene	0.85
Nafld	contributes_to	disease	0.85
PPAR	activates	gene	0.85
Nafld	treats	disease	0.85
LIPOPHAGY	activates	gene	0.85
Hepatocellular Carcinoma	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.75
MITOCHONDRIA	inhibits	gene	0.75
INSULIN RESISTANCE	inhibits	gene	0.75
INFLAMMATION	associated_with	gene	0.75
Obesity	activates	disease	0.75
Insulin Resistance	activates	disease	0.75
Hepatitis	activates	disease	0.75
Diabetes	causes	disease	0.75
DIABETES MELLITUS	activates	gene	0.75
Metabolic Syndrome	activates	disease	0.75
MICROGLIA	therapeutic_target	gene	0.75
SQSTM1	activates	gene	0.75
AMPK	activates	gene	0.75
Hepatitis	associated_with	disease	0.75
Inflammation	activates	disease	0.75
AMPK	therapeutic_target	gene	0.75
INFLAMMATION	implicated_in	gene	0.75
MITOPHAGY	therapeutic_target	gene	0.75
MITOCHONDRIA	therapeutic_target	gene	0.75
CYTOKINES	activates	gene	0.75

Associated Genes	ROS, INFLAMMATION, AKT, AUTOPHAGY, CANCER, LIPOPHAGY, DIABETES MELLITUS, INSULIN RESISTANCE
KG Connections	492 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Fatty Liver

Understanding Entity Pages

Wiki Pages (20)

APOC4 — Apolipoprotein C-IV

Peroxisomal Dysfunction

GPT - Alanine Transaminase (ALT)

Extracellular Vesicles in Neurodegeneration

Liver-Brain Neurodegeneration Axis

Pathway Diagram

Outgoing (110)

Incoming (386)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)

Fatty Liver

Understanding Entity Pages

Wiki Pages (20)

APOC4 — Apolipoprotein C-IV

Peroxisomal Dysfunction

GPT - Alanine Transaminase (ALT)

Extracellular Vesicles in Neurodegeneration

Liver-Brain Neurodegeneration Axis

NNMT Gene

Mitochondrially Impaired Neurons

SPART — Spartin

acc-chronic-pain

slc22a5

vcp-multisystem-proteinopathy

ANT2 (Adenine Nucleotide Translocator 2)

CIDEA — Cell Death-Inducing DFFA-Like Effector A

MARCHF2 — Membrane-Associated RING-CH Finger 2

ABCA1 Gene

CIDEC Gene

SPTLC1 Protein (Serine Palmitoyltransferase 1)

Lipophagy Activation Therapy for Neurodegeneration

GOT1 Gene

UCP2 — Uncoupling Protein 2

Pathway Diagram

Outgoing (110)

Incoming (386)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)