gene

TPPP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPPP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

7Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for TPPP Gene

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🧬 Gene Info

Gene Symbol	TPPP
Function	TPPP encodes a 219 amino acid intrinsically disordered protein with no conventional secondary structure domains.
Primary Expression	oligodendrocytes where it stabilizes microtubules and promotes tubulin acetylation
Amino Acids	219 aa
Pathways	Autophagy, Proteasome
Ensembl ID	ENSG00000171368
GeneCards	TPPP
Human Protein Atlas	TPPP
Glial cytoplasmic inclusions (GCIs)	TPPP co-localizes with aggregated alpha-synuclein in virtually all GCIs, the pathological hallmark of MSA
Seeding and templating	TPPP directly binds alpha-synuclein and promotes its aggregation into a GCI-specific amyloid strain distinct from Lewy body strains
Relocation	In MSA, TPPP relocates from its normal perinuclear/process distribution to the inclusion body, depleting it from microtubules and causing secondary demyelination
Temporal sequence	Evidence suggests TPPP accumulation precedes alpha-synuclein aggregation in GCIs — TPPP may create the initial seed
Strain specificity	The TPPP-alpha-synuclein complex generates a prion-like strain with unique structural properties, potentially explaining MSA's aggressive clinical course compared to PD
Associated Diseases	neurodegeneration
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TPPP["TPPP"]
    Als{"Als"}
    TPPP -->|"regulates"| Als
    Ms{"Ms"}
    TPPP -->|"contributes to"| Ms
    Proteasome(["Proteasome"])
    TPPP -->|"regulates"| Proteasome
    Autophagy(["Autophagy"])
    TPPP -->|"regulates"| Autophagy
    SNCA["SNCA"]
    TPPP -->|"regulates"| SNCA
    neurodegeneration["neurodegeneration"]
    TPPP -->|"implicated in"| neurodegeneration
    SNCA -->|"regulates"| TPPP
    style TPPP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Ms	contributes_to	disease	0.65
Proteasome	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
SNCA	regulates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
LYSOSOME	regulates	gene	0.60
SNCA	regulates	gene	0.60
AND	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TPPP in their description or question text

No additional research found