protein

TREM2 PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREM2 PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

7Outgoing

3Incoming

0Experiments

0Debates

Summary

TREM2 protein: microglial receptor for lipid/ApoE/Aβ ligands, AD risk gene, DAM transition, therapeutic target with Phase 2 trials

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🔬 Protein Info

Gene Symbol	TREM2
Full Name	Triggering receptor expressed on myeloid cells 2
Protein Family	receptor
Protein Type	Receptor
Function	is a cell-surface receptor predominantly expressed on microglia in the central nervous system.
Primary Expression	hippocampus, substantia nigra, cortex, white matter, spinal cord
Molecular Weight	26 kDa
Amino Acids	234 aa
Pathways	NLRP3 Inflammasome, Cholesterol Metabolism, lysosomal function, Classical Complement Cascade, Akt/CREB/BDNF signalling
GeneCards	TREM2
Human Protein Atlas	TREM2
Associated Diseases	ALZHEIMERS, Alzheimer, Neurodegeneration, NEURODEGENERATION, Microglial Metabolic Fitness, Dysfunctional Microglia
Interactions	ALZHEIMER, TREM2
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    N0["TREM2 PROTEIN"]
    N1["ALZHEIMER"]
    N0 -->|"activates"| N1
    N2["Alzheimer'S Disease"]
    N0 -->|"activates"| N2
    N3["disease"]
    N0 -->|"activates"| N3
    N4["ALZHEIMER'S"]
    N0 -->|"activates"| N4
    N5["Cortex"]
    N0 -->|"inhibits"| N5
    N6["Hippocampus"]
    N0 -->|"inhibits"| N6
    N7["FRONTAL"]
    N0 -->|"inhibits"| N7
    N8["TREM2"]
    N8 -->|"activates"| N0
    N9["late"]
    N9 -->|"activates"| N0
    N8 -->|"inhibits"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 disease
    class N3 disease
    class N8 gene
    class N9 disease

Outgoing (7)

Target	Relation	Type	Str
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
Cortex	inhibits	brain_region	0.50
Hippocampus	inhibits	entity	0.50
FRONTAL	inhibits	concept	0.50

Incoming (3)

Source	Relation	Type	Str
TREM2	activates	gene	0.50
late	activates	disease	0.50
TREM2	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TREM2 PROTEIN in their description or question text

No additional research found