concept

FRONTAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

206Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	FRONTAL
Key Genes/Proteins	FUS, SOD1, MTOR, C9ORF72
Related Diseases	FRONTOTEMPORAL, FTD, NEURODEGENERATION, DEMENTIA, ALS
Linked Hypotheses	8 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FRONTAL["FRONTAL"]
    style FRONTAL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FRONTAL -->|"causes"| FRONTOTEMPORAL["FRONTOTEMPORAL"]
    FRONTAL -->|"causes"| FTD["FTD"]
    FRONTAL -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    FRONTAL -->|"regulates"| FUS([FUS])
    FRONTAL -->|"regulates"| SOD1([SOD1])
    FRONTAL -->|"reduces"| HIPPOCAMPUS((HIPPOCAMPUS))
    FRONTAL -->|"activates"| MTOR([MTOR])
    FRONTAL -->|"sensitizes_to"| PREFRONTAL((PREFRONTAL))
    DEMENTIA["DEMENTIA"] -->|"causes"| FRONTAL
    ALS["ALS"] -->|"regulates"| FRONTAL
    C9ORF72([C9ORF72]) -->|"regulates"| FRONTAL
    AMYLOID["AMYLOID"] -->|"reduces"| FRONTAL
    AMYGDALA((AMYGDALA)) -->|"reduces"| FRONTAL
    CORTEX((CORTEX)) -->|"regulates"| FRONTAL
    DOPAMINERGIC["/DOPAMINERGIC/"] -->|"causes"| FRONTAL

Outgoing (74)

Target	Relation	Type	Str
FRONTOTEMPORAL	causes	disease	0.65
FTD	causes	disease	0.65
NEURODEGENERATION	causes	disease	0.65
FUS	regulates	gene	0.65
SOD1	regulates	gene	0.65
HIPPOCAMPUS	reduces	brain_region	0.65
MTOR	activates	gene	0.65
HIPPOCAMPUS	associated_with	brain_region	0.65
HIPPOCAMPUS	contributes_to	brain_region	0.65
PREFRONTAL	sensitizes_to	brain_region	0.65
PREFRONTAL	contributes_to	brain_region	0.65
PREFRONTAL	expressed_in	brain_region	0.60
PREFRONTAL	associated_with	brain_region	0.60
NEURON	expressed_in	cell_type	0.60
NEURONS	expressed_in	cell_type	0.60
NEURON	contributes_to	cell_type	0.60
HIPPOCAMPUS	regulates	brain_region	0.60
PREFRONTAL	regulates	brain_region	0.60
PTSD	regulates	disease	0.60
PREFRONTAL	activates	brain_region	0.60
MICROGLIA	expressed_in	cell_type	0.60
INTERNEURON	activates	cell_type	0.60
INTERNEURONS	activates	cell_type	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
INTERNEURON	inhibits	cell_type	0.60
INTERNEURONS	inhibits	cell_type	0.60
NEURON	inhibits	cell_type	0.60
NEURONS	inhibits	cell_type	0.60
PREFRONTAL	inhibits	brain_region	0.60
OCCIPITAL	associated_with	brain_region	0.60
SCHIZOPHRENIA	regulates	disease	0.60
PREFRONTAL	causes	brain_region	0.60
SUBSTANTIA NIGRA	causes	brain_region	0.60
VENTRAL TEGMENTAL	causes	brain_region	0.60
SLC1A2	activates	gene	0.60
LDLR	causes	gene	0.60
PREFRONTAL	mediates	brain_region	0.60
RAGE	regulates	gene	0.60
NEURODEGENERATION	regulates	disease	0.60
HIPPOCAMPUS	expressed_in	brain_region	0.60
NEURON	regulates	cell_type	0.60
OPTN	regulates	gene	0.60
TREM2	expressed_in	gene	0.60
GFAP	activates	gene	0.60
HIPPOCAMPUS	activates	brain_region	0.60
MICROGLIA	causes	cell_type	0.60
AMYGDALA	activates	concept	0.50
ENTORHINAL CORTEX	associated_with	concept	0.50
TEMPORAL LOBE	associated_with	concept	0.50

Incoming (132)

Source	Relation	Type	Str
DEMENTIA	causes	disease	0.65
ALS	regulates	disease	0.65
C9ORF72	regulates	gene	0.65
AMYGDALA	reduces	brain_region	0.65
CORTEX	associated_with	brain_region	0.65
ANXIETY	associated_with	disease	0.65
ALS	sensitizes_to	disease	0.65
CORTEX	regulates	brain_region	0.65
CORTEX	expressed_in	brain_region	0.60
DOPAMINERGIC	causes	cell_type	0.60
DEPRESSION	associated_with	disease	0.60
DEMENTIA	regulates	disease	0.60
CORTEX	contributes_to	brain_region	0.60
CORTEX	activates	brain_region	0.60
DEPRESSION	activates	disease	0.60
AMYGDALA	regulates	brain_region	0.60
CHRNA7	expressed_in	gene	0.60
CORTEX	causes	brain_region	0.60
ABCA1	causes	gene	0.60
APOE	causes	gene	0.60
CYP46A1	causes	gene	0.60
DEPRESSION	causes	disease	0.60
ANXIETY	expressed_in	disease	0.60
DEPRESSION	expressed_in	disease	0.60
CORTEX	mediates	brain_region	0.60
DRD2	mediates	gene	0.60
DRD2	regulates	gene	0.60
CX3CR1	biomarker_for	gene	0.60
CX3CR1	causes	gene	0.60
Dna Methylation	associated_with	pathway	0.50
Cortex	associated_with	brain_region	0.50
DOPAMINERGIC	associated_with	concept	0.50
STRIATUM	associated_with	concept	0.50
DOPAMINE	associated_with	concept	0.50
ANXIETY	interacts_with	gene	0.50
White Matter	interacts_with	process	0.50
DEPRESSION	interacts_with	disease	0.50
Neurodegeneration	associated_with	disease	0.50
DEMENTIA	associated_with	gene	0.50
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
disease	associated_with	disease	0.50
FRONTOTEMPORAL	associated_with	concept	0.50
amyotrophic lateral sclerosis	associated_with	gene	0.50
Hippocampus	activates	entity	0.50
mTOR	activates	entity	0.50
RHEB	activates	gene	0.50
late	interacts_with	disease	0.50
Cortex	interacts_with	brain_region	0.50
Hippocampus	interacts_with	entity	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial alternating current stimulation to	0.639	Alzheimer's disease	Circuit-level neural dynamics in neurode
Prefrontal sensory gating circuit restoration via PV interne	0.587	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Transcriptional and functional profiles of muscarinic receptor-expressing neuron [PMID:41857244]	Tsolias A, Mojica CA, Yamani R, Khanna S	Communications biology	2026
Neurophysiological and neuropharmacological effects of melatonin MT2 receptors a [PMID:41571206]	["Barzon B", "Marchiotto F", "Nasini S",	Biochemical pharmacology	2026
Enhanced interhemispheric functional connectivity in elderly anxiety patients wi [PMID:41656398]	["Chang Y", "Liu M", "Liu Y", "Xie X", "	Scientific reports	2026
Convergent transcriptomic and connectomic controllers of information integration [PMID:41606107]	Luppi AI, Uhrig L, Tasserie J, Mediano P	Nature human behaviour	2026
Transcranial direct current stimulation restores addictive behavior via prefront [PMID:41136747]	["Zuo H", "Zhang W", "Wang L", "Wu Y", "	Molecular psychiatry	2026
Meta-Analyses of Auditory Evoked Potentials as Alzheimer Biomarkers. [PMID:40836165]	Bayat A, Mirmomeni G, Aiken S, Jafari Z	Ear and hearing	2026
Establishing mouse forebrain organoids as models of intrinsic cortical network a [PMID:41791384]	Hernandez S, Schweiger HE, Cline I, Kaur	Stem cell reports	2026
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138]	Singer Y, Yitzhaky A, Hertzberg L	Alpha psychiatry	2026
A silent Kv channel subunit shapes PV neuron action potential waveform and short [PMID:41632839]	Ganesh S, Canty TM, Sabatini BL	Proceedings of the National Ac	2026
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026
Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomati [PMID:41279752]	Mandal P, Trushina E, Arnold M, Kaddurah	bioRxiv : the preprint server	2025
Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Pre [PMID:40426616]	["Liu W", "Li N", "Tang D", "Qin L", "Zh	Brain sciences	2025
Medial prefrontal cortex circuit dynamics involved in stage-specific addiction. [PMID:41307570]	["Zhao D", "Zhang X", "Bai J"]	Brain structure & function	2025
Studies in rats of a target specific and reversible general anesthetic with a fa [PMID:41187127]	["Xie Z", "Fong R", "Fox A"]	PloS one	2025
tDCS-induced enhancement of cognitive flexibility in autism: role of frontal lob [PMID:40874060]	["Han Y", "Dong A", "Xia C", "Zhang Z",	Frontiers in behavioral neuros	2025
Fate plasticity of interneuron specification. [PMID:40264797]	["Mostajo-Radji M", "Leon W", "Breevoort	iScience	2025
The thalamic reticular nucleus orchestrates social memory. [PMID:38701789]	Wang F, Sun H, Chen M, Feng B, Lu Y, Lyu	Neuron	2024
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nature neuroscience	2024
A vagal reflex evoked by airway closure. [PMID:38448588]	["Schappe M", "Brinn P", "Joshi N", "Gre	Nature	2024
Parvalbumin interneuron mGlu [PMID:38773314]	["Fabian C", "Jordan N", "Cole R", "Carl	Neuropsychopharmacology : offi	2024

FRONTAL

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

primary-progressive-aphasia

Atypical Parkinsonism

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

PI-2620 Tau PET in PSP

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

NTF4 Protein

GSK-3β in Neurodegeneration

HNRNPA2B1 Protein

Mitochondrial Dysfunction in Parkinson's Disease