gene

TWINKLE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TWINKLE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

4Outgoing

6Incoming

0Experiments

0Debates

Summary

TWNK Gene

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🧬 Gene Info

Gene Symbol	TWNK
Full Name	Twinkle mtDNA Helicase
Chromosome	10q24.31
Function	TWNK is a mitochondrial DNA helicase that unwinds double-stranded mtDNA during replication.
Subcellular Localization	mitochondria (2001)](https://pubmed.ncbi.nlm.nih.gov/11431692/)
Pathways	Autophagy, Mitophagy
UniProt ID	Q9NYV5
NCBI Gene ID	56652
Ensembl ID	ENSG00000107815
OMIM	604367
GeneCards	TWNK
Human Protein Atlas	TWNK
Associated Diseases	neurodegeneration
Interactions	AND, MTDNA
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TWINKLE — AlphaFold Q9NYV5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TWNK Gene

gene · 542 words

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Pathway Diagram

flowchart TD
    N0["TWINKLE"]
    N1["ENDOSOMES"]
    N0 -->|"regulates"| N1
    N2["AUTOPHAGY"]
    N0 -->|"regulates"| N2
    N3["Mitophagy"]
    N0 -->|"regulates"| N3
    N4["Autophagy"]
    N0 -->|"regulates"| N4
    N5["AND"]
    N5 -->|"activates"| N0
    N6["MITOPHAGY"]
    N6 -->|"regulates"| N0
    N7["MTDNA"]
    N7 -->|"activates"| N0
    N8["ATG5"]
    N8 -->|"regulates"| N0
    N9["MITOCHONDRIAL DYSFUNCTION"]
    N9 -->|"regulates"| N0
    N10["VPS35"]
    N10 -->|"regulates"| N0
    N11["neurodegeneration"]
    N0 -->|"implicated in"| N11

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 pathway
    class N4 pathway
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene

Outgoing (4)

Target	Relation	Type	Str
ENDOSOMES	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
Mitophagy	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
AND	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
MTDNA	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
ATG5	regulates	gene	0.60
VPS35	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TWINKLE in their description or question text

No additional research found