Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBE2N: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
UBE2N is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Cancer, Colorectal Cancer, Tumor. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | UBE2N |
| Full Name | Ubiquitin-Conjugating Enzyme E2 N |
| Chromosome | 19q13.43 |
| Protein Type | Enzyme |
| Function | Initiation: UBE2N~Ub thioester forms via ATP-dependent charging |
| Molecular Weight | 17 kDa |
| Pathways | NF-κB, NF-κB Signaling |
| UniProt ID | [P61079](https://www.uniprot.org/uniprot/P61079) |
| Ensembl ID | ENSG00000108987 |
| OMIM | 607252 |
| GeneCards | UBE2N |
| Human Protein Atlas | UBE2N |
| NF-κB Signaling | Lys63-polyubiquitin chains on TRAF6, NEMO, and other signaling intermediates activate NF-κB transcription factors[@adhikari2007] |
| DNA Damage Repair | UBE2N-mediated ubiquitination promotes recruitment of repair factors to DNA double-strand breaks[@hofmann2009] |
| Endosomal Trafficking | Ubiquitination of membrane proteins regulates sorting into multivesicular bodies |
| Associated Diseases | ALS |
| Interactions | TAK1, CDK1, DNAJB6, PPP2CB, Rb, NF-ΚB |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
UBE2N["<b>UBE2N</b>"]
Colorectal_Cancer{"Colorectal Cancer"}
UBE2N -->|"activates"| Colorectal_Cancer
Cancer{"Cancer"}
UBE2N -->|"activates"| Cancer
Tumor{"Tumor"}
UBE2N -->|"activates"| Tumor
TAK1(["TAK1"])
UBE2N -->|"activates"| TAK1
NF__B(["NF-KappaB"])
UBE2N -->|"activates"| NF__B
FERROPTOSIS(["FERROPTOSIS"])
UBE2N -->|"activates"| FERROPTOSIS
FTH1(["FTH1"])
FTH1 -->|"activates"| UBE2N
style UBE2N fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Encephalitis | interacts_with | disease | 0.65 |
| Colorectal Cancer | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| TAK1 | activates | gene | 0.60 |
| CDK1 | activates | gene | 0.60 |
| DNAJB6 | interacts_with | gene | 0.60 |
| PPP2CB | interacts_with | gene | 0.60 |
| Rb | interacts_with | protein | 0.60 |
| NF-ΚB | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| Metastasis | activates | pathway | 0.60 |
| Nf-Κb | activates | pathway | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| CRBN | interacts_with | gene | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| Actin | interacts_with | protein | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Proteins | interacts_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||