gene

TAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

255Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TAK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 152 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TAK1
Aliases	Transforming Growth Factor-beta-Activated Kinase 1
Protein Family	MAP3K kinases
Protein Type	Kinase
Function	TAK1 (Transforming Growth Factor-beta-Activated Kinase 1) is a serine/threonine kinase that activates NF-κB and MAPK pathways in response to cytokines (TNF-α, IL-1), TLR ligands, and stress.
Molecular Weight	67 kDa
Pathways	NF-κB, MAPK pathway, NF-κB Signaling, MAPK Signaling, MAPK
UniProt ID	[O43318](https://www.uniprot.org/uniprot/O43318)
GeneCards	TAK1
Human Protein Atlas	TAK1
Associated Diseases	Encephalitis, Multiple Sclerosis, neuroinflammation
Interactions	IKBKB, IL6, LC3, PRDX1, JUN, CXCL10
KG Connections	255 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TAK1["TAK1"] -->|"activates"| Cancer["Cancer"]
    TAK1["TAK1"] -->|"activates"| Als["Als"]
    TAK1["TAK1"] -->|"activates"| Ms["Ms"]
    TAK1["TAK1"] -.->|"inhibits"| Als_1["Als"]
    TAK1["TAK1"] -->|"therapeutic target"| Cancer_2["Cancer"]
    TAK1["TAK1"] -.->|"inhibits"| Tumor["Tumor"]
    P38["P38"] -->|"activates"| TAK1["TAK1"]
    MAP1LC3["MAP1LC3"] -->|"activates"| TAK1["TAK1"]
    IL1B["IL1B"] -->|"activates"| TAK1["TAK1"]
    PRDX1["PRDX1"] -->|"activates"| TAK1["TAK1"]
    style TAK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (176)

Target	Relation	Type	Str
TNF-α signaling	regulates	pathway	0.88
Cancer	activates	disease	0.85
Als	activates	disease	0.85
Tumor	activates	disease	0.85
UBIQUITIN	activates	gene	0.80
CANCER	activates	gene	0.80
Cancer	therapeutic_target	disease	0.75
Autophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Apoptosis	activates	pathway	0.70
Encephalitis	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Ms	regulates	disease	0.65
Infection	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Colorectal Cancer	activates	disease	0.65
Huntington	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Type 2 Diabetes	activates	disease	0.65
Diabetes	activates	disease	0.65
Alzheimer	activates	disease	0.65
Fibrosis	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
LC3	activates	gene	0.60
PRDX1	activates	gene	0.60
JUN	activates	gene	0.60
CXCL10	activates	gene	0.60
P38	therapeutic_target	gene	0.60
DLK1	therapeutic_target	gene	0.60
NRF2	activates	gene	0.60
NFE2L2	activates	gene	0.60
TFE3	activates	gene	0.60
P62	activates	gene	0.60
STK11	activates	gene	0.60
MAPK14	activates	gene	0.60
RELA	activates	gene	0.60
PRDX6	activates	gene	0.60
P38	activates	gene	0.60
TRAF6	activates	gene	0.60
TNF	activates	gene	0.60
TLR4	activates	gene	0.60

Incoming (79)

Source	Relation	Type	Str
MAP3K7	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
P38	activates	gene	0.60
IL1B	activates	gene	0.60
PRDX1	activates	gene	0.60
TRAF6	activates	gene	0.60
CHUK	activates	gene	0.60
PRDX6	activates	gene	0.60
MAPK14	activates	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
ECSIT	activates	gene	0.60
TLR4	activates	gene	0.60
RELA	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
LC3	activates	gene	0.60
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
MAPK8	inhibits	gene	0.60
JUN	therapeutic_target	gene	0.60
MAP3K7	inhibits	gene	0.60
ERN1	inhibits	gene	0.60
RIPK1	activates	gene	0.60
ZBP1	activates	gene	0.60
RIPK3	activates	gene	0.60
RIPK1	regulates	gene	0.60
ZBP1	regulates	gene	0.60
RIPK3	regulates	gene	0.60
NLRP3	regulates	gene	0.60
FADD	regulates	gene	0.60
STUB1	interacts_with	gene	0.60
ERK1	therapeutic_target	gene	0.60
JNK1	therapeutic_target	gene	0.60
TFEB	activates	gene	0.60
PP2A	activates	gene	0.60
KEAP1	activates	gene	0.60
SQSTM1	activates	gene	0.60
TIGAR	activates	gene	0.60
FTH1	activates	gene	0.60
UBE2N	activates	gene	0.60
APP	activates	gene	0.60
APEX2	activates	gene	0.60
GSDMD	inhibits	gene	0.60
NLRP3	activates	gene	0.60
ASC	activates	gene	0.60
ALOX12	activates	gene	0.60
MAP1LC3	activates	gene	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
NF-KB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TAK1

Understanding Entity Pages

Summary

Wiki Pages (21)

TAK1 Gene

Novel Therapy Index

omega-3-fatty-acids-neurodegeneration

LRRK2 G2019S

Advanced Glycation End Products in Neurodegeneration

TGF-β Signaling in Parkinson's Disease

Neuroinflammation in Parkinson's Disease

cGAS-STING Signaling in Parkinson's Disease

Necroptosis Pathway in Neurodegeneration

UBE2V1 Gene (UEV-1)

MAPK9 Gene

MAPK/ERK Signaling Pathway in Neurodegeneration

TLR5-Mediated Microglial Neuroinflammation Hypothesis

jnk-p38-mapk-parkinsons

Regulated Necrosis Hypothesis in Parkinson's Disease

NF-κB Signaling in Neurodegeneration

AMPK Signaling Pathway

Neuroinflammation Comparison — AD/PD/ALS/FTD/HD

p75NTR Protein