gene

ULK4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ULK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

Summary

Unc-51 Like Kinase 4 - serine/threonine kinase in autophagy initiation

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🧬 Gene Info

Gene Symbol	ULK4
Aliases	Unc-51 Like Kinase 4
Chromosome	3p21.2.
Protein Type	Serine/Threonine Kinase
Function	The ULK4 gene encodes a serine/threonine kinase with the following functions
Primary Expression	the brain and has been implicated in neurodevelopment, axon guidance, and neurodegenerative diseases including Alzheimer's disease, Parkinson's diseas
Molecular Weight	170 kDa
Amino Acids	068 aa
Pathways	mTOR
GeneCards	ULK4
Human Protein Atlas	ULK4
Associated Diseases	neurodegeneration
Interactions	App, DEPRESSION
KG Connections	14 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ULK4 Gene

gene · 1446 words

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ULK4 Protein

protein · 611 words

→

Pathway Diagram

flowchart TD
    N0["ULK4"]
    N1["Schizophrenia"]
    N0 -->|"inhibits"| N1
    N2["Depression"]
    N0 -->|"inhibits"| N2
    N3["Anxiety"]
    N0 -->|"regulates"| N3
    N4["DEPRESSION"]
    N0 -->|"inhibits"| N4
    N5["ANXIETY"]
    N0 -->|"regulates"| N5
    N6["AND"]
    N0 -->|"inhibits"| N6
    N7["App"]
    N0 -->|"inhibits"| N7
    N4 -->|"inhibits"| N0
    N8["SCHIZOPHRENIA"]
    N8 -->|"inhibits"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 protein
    class N8 disease

Outgoing (10)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ULK4	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Anxiety	regulates	disease	0.65
Schizophrenia	inhibits	disease	0.65
Depression	inhibits	disease	0.65
schizophrenia	inhibits	disease	0.60
DEPRESSION	inhibits	gene	0.60
ANXIETY	regulates	gene	0.60
App	inhibits	protein	0.60
autism spectrum disorder	inhibits	disease	0.60

Incoming (4)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ULK4	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
DEPRESSION	inhibits	gene	0.60
SCHIZOPHRENIA	inhibits	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ULK4 in their description or question text

No additional research found