disease

SCHIZOPHRENIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCHIZOPHRENIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1330Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	APOE, JUN, BDNF, PARKIN, CYTOKINES, AMYLOID, AKT, PI3K
KG Connections	441 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"associated"| SYNGR1["SYNGR1"]
    style SYNGR1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| SLEEP["SLEEP"]
    style SLEEP fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| SYNAPSE["SYNAPSE"]
    style SYNAPSE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    SCHIZOPHRENIA["SCHIZOPHRENIA"] -->|"co discussed"| TEMPORAL_LOBE["TEMPORAL LOBE"]
    style TEMPORAL_LOBE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    RELN["RELN"] -->|"implicated in"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style RELN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ALZHEIMER_S["ALZHEIMER'S"] -->|"causes"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style ALZHEIMER_S fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    PARKIN["PARKIN"] -->|"causes"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    style PARKIN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style SCHIZOPHRENIA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (350)

Target	Relation	Type	Str
STING	regulates	gene	0.65
TH	inhibits	gene	0.65
DOPAMINE	regulates	phenotype	0.65
CEREBELLUM	interacts_with	brain_region	0.65
STROKE	associated_with	disease	0.60
STING	contributes_to	gene	0.60
TH	impairs	gene	0.60
SYNGR1	associated_with	entity	0.60
NEURODEGENERATION	activates	process	0.50
NEURODEGENERATION	inhibits	process	0.50
AUTOPHAGY	associated_with	process	0.50
NEURODEGENERATION	associated_with	process	0.50
REELIN	interacts_with	protein	0.50
ALZHEIMER	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
Bipolar	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
SEROTONIN	activates	concept	0.50
PARKINSON	associated_with	gene	0.50
Parkinson's Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
PARKINSON'S	associated_with	concept	0.50
PLA2G4A	associated_with	gene	0.50
PLA2G6	activates	gene	0.50
PLA2G4A	activates	gene	0.50
PLA2G4A	inhibits	gene	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
HUNTINGTON	associated_with	gene	0.50
HUNTINGTON'S DISEASE	associated_with	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
HUNTINGTON'S	associated_with	concept	0.50
Pain	associated_with	disease	0.50
COMPLEMENT	interacts_with	pathway	0.50
COMPLEMENT	inhibits	pathway	0.50
SYNAPSE	inhibits	concept	0.50
mTOR	inhibits	entity	0.50
ISCHEMIA	inhibits	disease	0.50
Autophagy	associated_with	process	0.50
mTOR	associated_with	entity	0.50
OBESITY	associated_with	disease	0.50
ANXIETY	associated_with	gene	0.50
Microbiota	associated_with	process	0.50
Gut Microbiota	associated_with	process	0.50
RGS4	interacts_with	gene	0.50

Incoming (980)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
C4B	risk_gene_for	gene	0.90
RELN	implicated_in	entity	0.85
ALZHEIMER'S DISEASE	interacts_with	disease	0.80
BIPOLAR DISORDER	associated_with	disease	0.80
MICROBIOTA	implicated_in	biological_process	0.80
ALS	associated_with	disease	0.74
APOE	associated_with	gene	0.66
MICROGLIA	associated_with	cell_type	0.66
ALZHEIMER'S	causes	disease	0.65
PARKIN	causes	gene	0.65
PARKINSON'S	causes	disease	0.65
BIPOLAR DISORDER	interacts_with	disease	0.65
CORTEX	regulates	brain_region	0.65
NEURONS	causes	cell_type	0.65
GABA	interacts_with	phenotype	0.65
DRD2	inhibits	gene	0.65
MELATONIN	activates	drug	0.65
BDNF	increases_risk	gene	0.65
LACTATE	regulates	phenotype	0.65
SEROTONIN	causes	phenotype	0.65
ALZHEIMER'S	associated_with	disease	0.60
PARKINSON'S DISEASE	contributes_to	disease	0.60
MICROGLIA	regulates	cell_type	0.60
MICROGLIA	targets	cell_type	0.60
ALZHEIMER	biomarker_for	disease	0.60
ALZHEIMER'S	biomarker_for	disease	0.60
ALZHEIMER'S DISEASE	biomarker_for	disease	0.60
NEURON	causes	cell_type	0.60
PARKIN	associated_with	gene	0.60
PARKINSON'S	associated_with	disease	0.60
GLIOMA	associated_with	disease	0.60
HUNTINGTON'S	associated_with	disease	0.60
INTERNEURON	regulates	cell_type	0.60
NEURONS	regulates	cell_type	0.60
INTERNEURON	associated_with	cell_type	0.60
NEURONS	associated_with	cell_type	0.60
INTERNEURON	impairs	cell_type	0.60
NEURON	impairs	cell_type	0.60
FRONTAL	regulates	brain_region	0.60
DRD2	contributes_to	gene	0.60
GLUTAMATERGIC	contributes_to	cell_type	0.60
DRD2	causes	gene	0.60
ENDOTHELIAL	associated_with	cell_type	0.60
MACROPHAGE	associated_with	cell_type	0.60
BIPOLAR	regulates	disease	0.60
CORTEX	expressed_in	brain_region	0.60
CHOLINERGIC	contributes_to	cell_type	0.60
PLA2G4A	expression	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SCHIZOPHRENIA

Understanding Entity Pages

Wiki Pages (20)

primary-progressive-aphasia

GRIA3 Gene

Frontotemporal Dementia (FTD)

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

CNTN5 — Contactin 5

CNTN4 — Contactin 4

Sulforaphane and Nrf2 Activation for Neuroprotection

substantia-nigra

dimethyl-fumarate-nrf2-ad-nct06850597

CNTN3 — Contactin 3

NPAS3 Gene

PEN2 Gene

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 2 (NCT06976203)

Beta-Secretase (BACE1) Protein

Multiple Sclerosis (MS)

Metabolomic Alterations in PSP