Blood-Brain Barrier SPM Transporter Upregulation
🧪 Overview
The BBB limits SPM access to brain tissue. Targeted upregulation of lipid transporters (OATP, FATP) or temporary BBB permeabilization during SPM therapy could enhance central nervous system SPM bioavailability.
Debate provenance: derived from debate `sess_sda-2026-04-01-gap-014` on question: SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation resolution. Are resolution failures druggable?. Consensus signal: domain_expert, skeptic, synthesizer, theorist discussed the mechanism terms BBB, Barrier, Blood-Brain, FATP, OATP, SLC27A1, SLCO1A4, SPM. Novelty signal: skeptic-discussed-with-qualified-concession.
🧬 Mechanism
Auto-built from this analysis's top knowledge-graph edges.
graph TD
TFRC["TFRC"] -->|encodes| transferrin_receptor["transferrin_receptor"]
transferrin_receptor_1["transferrin_receptor"] -->|mediates| blood_brain_barrier_trans["blood_brain_barrier_transport"]
CMKLR1["CMKLR1"] -->|encodes| GPR32["GPR32"]
GPR32_2["GPR32"] -->|regulates| microglial_efferocytosis["microglial_efferocytosis"]
microglial_efferocytosis_3["microglial_efferocytosis"] -->|resolves| neuroinflammation["neuroinflammation"]
BCL2L1["BCL2L1"] -->|encodes| BCL_xL["BCL-xL"]
BCL_xL_4["BCL-xL"] -->|promotes| senescent_cell_survival["senescent_cell_survival"]
ALOX12["ALOX12"] -->|encodes| n12_lipoxygenase["12-lipoxygenase"]
n12_lipoxygenase_5["12-lipoxygenase"] -->|catalyzes| maresin_biosynthesis["maresin_biosynthesis"]
ALOX15["ALOX15"] -->|encodes| n15_lipoxygenase["15-lipoxygenase"]
n15_lipoxygenase_6["15-lipoxygenase"] -->|catalyzes| lipoxin_A4_synthesis["lipoxin_A4_synthesis"]
lipoxin_A4_synthesis_7["lipoxin_A4_synthesis"] -->|regulates| astrocyte_polarization["astrocyte_polarization"]
style TFRC fill:#ce93d8,stroke:#333,color:#000
style transferrin_receptor fill:#4fc3f7,stroke:#333,color:#000
style transferrin_receptor_1 fill:#4fc3f7,stroke:#333,color:#000
style blood_brain_barrier_trans fill:#81c784,stroke:#333,color:#000
style CMKLR1 fill:#ce93d8,stroke:#333,color:#000
style GPR32 fill:#4fc3f7,stroke:#333,color:#000
style GPR32_2 fill:#4fc3f7,stroke:#333,color:#000
style microglial_efferocytosis fill:#81c784,stroke:#333,color:#000
style microglial_efferocytosis_3 fill:#81c784,stroke:#333,color:#000
style neuroinflammation fill:#ef5350,stroke:#333,color:#000
style BCL2L1 fill:#ce93d8,stroke:#333,color:#000
style BCL_xL fill:#4fc3f7,stroke:#333,color:#000
style BCL_xL_4 fill:#4fc3f7,stroke:#333,color:#000
style senescent_cell_survival fill:#81c784,stroke:#333,color:#000
style ALOX12 fill:#ce93d8,stroke:#333,color:#000
style n12_lipoxygenase fill:#4fc3f7,stroke:#333,color:#000
style n12_lipoxygenase_5 fill:#4fc3f7,stroke:#333,color:#000
style maresin_biosynthesis fill:#81c784,stroke:#333,color:#000
style ALOX15 fill:#ce93d8,stroke:#333,color:#000
style n15_lipoxygenase fill:#4fc3f7,stroke:#333,color:#000
style n15_lipoxygenase_6 fill:#4fc3f7,stroke:#333,color:#000
style lipoxin_A4_synthesis fill:#81c784,stroke:#333,color:#000
style lipoxin_A4_synthesis_7 fill:#81c784,stroke:#333,color:#000
style astrocyte_polarization fill:#81c784,stroke:#333,color:#000⚖️ Evidence
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — SLCO1A4
No curated PDB or AlphaFold mapping for SLCO1A4 yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for SLCO1A4, SLC27A1.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
📊 Market Indicators
💾 Resource Usage
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_round_mining
| source | v1_phase_c_backfill |
| origin_type | debate_round_mining |
| _schema_version | 1 |