concept

VEGF-B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VEGF-B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections
0Hypotheses
0Analyses
16Outgoing
8Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameVEGF-B
Key Genes/ProteinsFGFR1, GRP78, PERK, DIABETES MELLITUS, ATF4, Vegf
Related DiseasesDiabetes, Cardiomyopathy
Related PathwaysAutophagy

Wiki Pages (15)

Knowledge base pages for this entity

VEGF/Angiogenesis Pathway in Neurodegeneration

mechanism · 4480 words

Growth Factor Therapeutics: Investment Landscape Analysis

investment · 4064 words

vegfr-signaling-neurodegeneration

mechanism · 3496 words

VEGF Signaling and Cerebral Angiogenesis in Neurodegeneration

mechanism · 2920 words

Neurovascular and Blood-Brain Barrier Dysfunction in Corticobasal Syndrome

mechanism · 2890 words

Pathway Diagram

graph TD
    VEGF_B["VEGF-B"]
    VEGF_B -->|"binds_to"| FGFR1["FGFR1"]
    VEGF_B -->|"promotes"| FGFR1_VEGFR1_complex_formation["FGFR1/VEGFR1 complex formation"]
    VEGF_B -->|"inhibits"| ERK_activation["ERK activation"]
    VEGF_B -->|"inhibits"| angiogenesis["angiogenesis"]
    VEGF_B -->|"interacts"| GRP78["GRP78"]
    VEGF_B -->|"inhibits"| Diabetes["Diabetes"]
    VEGF_B -->|"activates"| Cardiomyopathy["Cardiomyopathy"]
    VEGF_B -->|"inhibits"| PERK["PERK"]
    Melatonin["Melatonin"] -->|"downregulates"| VEGF_B
    VEGF["VEGF"] -->|"inhibits"| VEGF_B
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| VEGF_B
    RNA["RNA"] -->|"interacts"| VEGF_B
    AND["AND"] -->|"inhibits"| VEGF_B
    ATF4["ATF4"] -->|"inhibits"| VEGF_B
    PERK -->|"inhibits"| VEGF_B

Outgoing (16)

TargetRelationTypeStr
FGFR1binds_toprotein0.95
FGFR1/VEGFR1 complex formationpromotesprocess0.95
ERK activationinhibitsprocess0.93
angiogenesisinhibitsprocess0.92
GRP78interacts_withprotein0.85

Incoming (8)

SourceRelationTypeStr
VEGFinhibitsgene0.60
AUTOPHAGYactivatesgene0.60
RNAinteracts_withgene0.60
ANDinhibitsgene0.60
ATF4inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found