Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Cardiomyocyte: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Cell Type | Cardiomyocyte |
| Also Known As | Cardiac myocyte, Heart muscle cell, Cardiomyocytes |
| Key Pathways | Excitation-contraction coupling, Calcium cycling (SERCA2a/RyR2), Sarcomere function, beta-adrenergic signaling, Mitochondrial OXPHOS (25% mitochondria by volume) |
| Associated Diseases | Dilated cardiomyopathy (DCM), Hypertrophic cardiomyopathy (HCM), Heart failure, Friedreich's ataxia (cardiomyopathy), Danon disease (LAMP2) |
| Related Genes | NRF2, GSH, FERROPTOSIS, SIRT3, ALOX15, UBIQUITIN |
| Linked Hypotheses | 18 hypotheses |
Knowledge base pages for this entity
graph TD
ALOX15["ALOX15"] -->|"expressed in"| Cardiomyocyte["Cardiomyocyte"]
style ALOX15 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Ferroptosis["Ferroptosis"] -->|"involved in"| Cardiomyocyte["Cardiomyocyte"]
style Ferroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Canagliflozin["Canagliflozin"] -->|"targets"| Cardiomyocyte["Cardiomyocyte"]
style Canagliflozin fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
NRF2["NRF2"] -->|"expressed in"| Cardiomyocyte["Cardiomyocyte"]
style NRF2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
GSH["GSH"] -.->|"inhibits"| Cardiomyocyte["Cardiomyocyte"]
style GSH fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style Cardiomyocyte fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| ALOX15 | expressed_in | gene | 0.90 |
| Ferroptosis | involved_in | process | 0.87 |
| Canagliflozin | targets | drug | 0.80 |
| NRF2 | expressed_in | gene | 0.75 |
| GSH | inhibits | gene | 0.60 |
| FERROPTOSIS | inhibits | gene | 0.60 |
| SIRT3 | inhibits | gene | 0.60 |
| NRF2 | inhibits | gene | 0.60 |
| ALOX15 | activates | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| APOPTOSIS | causes | gene | 0.60 |
| AUTOPHAGY | causes | gene | 0.60 |
| CKB | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| BCL2 | inhibits | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| AUTOPHAGY | contributes_to | gene | 0.60 |
| PDGF | associated_with | gene | 0.60 |
| LMNA | activates | gene | 0.60 |
| PDGFRB | associated_with | gene | 0.60 |
| CCL2 | inhibits | gene | 0.60 |
| CYTOKINES | inhibits | gene | 0.60 |
| MTORC1 | inhibits | gene | 0.60 |
| ATF4 | inhibits | gene | 0.60 |
| RNA | inhibits | gene | 0.60 |
| PERK | protects_against | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| VEGF-B | protects_against | gene | 0.60 |
| STING | inhibits | gene | 0.60 |
| DSDNA | activates | gene | 0.60 |
| GPX4 | contributes_to | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| CGAS | inhibits | gene | 0.60 |
| MITOPHAGY | activates | gene | 0.60 |
| JAK2 | inhibits | gene | 0.60 |
| BCL-2 | inhibits | gene | 0.60 |
| BAX | inhibits | gene | 0.60 |
| ANXA5 | inhibits | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| RS7529220 | associated_with | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| PLEC | activates | gene | 0.60 |
| C1Q | associated_with | gene | 0.60 |
| NOTCH1 | therapeutic_target | gene | 0.60 |
| CCND1 | inhibits | gene | 0.60 |
| ERK | activates | gene | 0.60 |
| CYP1A1 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||