protein

GRP78

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRP78: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

84Connections

0Hypotheses

0Analyses

27Outgoing

50Incoming

0Experiments

Summary

Page for GRP78 — Glucose-Regulated Protein 78

View on Wiki →

🔬 Protein Info

Gene Symbol	GRP78
Function	In neurodegenerative diseases, BiP serves as both a sensor of ER stress and a protective factor against protein aggregation.
Molecular Weight	78 kDa
Pathways	OXIDATIVE PHOSPHORYLATION, Microrna, Chaperone
GeneCards	GRP78
Human Protein Atlas	GRP78
Associated Diseases	ALS, multiple sclerosis
Interactions	PERK, VPS34, IFNG, MAPK, VEGF-B, LRRK2
KG Connections	84 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GRP78["<b>GRP78</b>"]
    Blood_Brain_Barrier["Blood-Brain Barrier"]
    GRP78 -->|"involved in"| Blood_Brain_Barrier
    PERK["PERK"]
    GRP78 -->|"interacts with"| PERK
    VEGF_B["VEGF-B"]
    VEGF_B -->|"interacts with"| GRP78
    VPS34["VPS34"]
    GRP78 -->|"activates"| VPS34
    IFNG["IFNG"]
    GRP78 -->|"activates"| IFNG
    cancer["cancer"]
    GRP78 -->|"activates"| cancer
    MAPK["MAPK"]
    GRP78 -->|"activates"| MAPK
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    GRP78 -->|"activates"| OXIDATIVE_PHOSPHORYLATION
    MTORC1["MTORC1"]
    GRP78 -->|"activates"| MTORC1
    Stem_Cell["Stem Cell"]
    GRP78 -->|"activates"| Stem_Cell
    Epithelial_Cell["Epithelial Cell"]
    GRP78 -->|"activates"| Epithelial_Cell
    disease["disease"]
    GRP78 -->|"activates"| disease
    Dendritic_Cell["Dendritic Cell"]
    GRP78 -->|"activates"| Dendritic_Cell
    CYP1A1["CYP1A1"]
    GRP78 -->|"activates"| CYP1A1
    DNA_DAMAGE["DNA DAMAGE"]
    GRP78 -->|"activates"| DNA_DAMAGE
    COLORECTAL_CANCER["COLORECTAL CANCER"]
    GRP78 -->|"activates"| COLORECTAL_CANCER
    Microrna["Microrna"]
    GRP78 -->|"activates"| Microrna
    Inflammatory_Bowel_Disease["Inflammatory Bowel Disease"]
    GRP78 -->|"activates"| Inflammatory_Bowel_Disease
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    GRP78 -->|"activates"| Reactive_Oxygen_Species
    RAPAMYCIN["RAPAMYCIN"]
    GRP78 -->|"activates"| RAPAMYCIN
    NUCLEUS["NUCLEUS"]
    GRP78 -->|"activates"| NUCLEUS
    ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
    GRP78 -->|"activates"| ENDOPLASMIC_RETICULUM
    PEROXISOME["PEROXISOME"]
    GRP78 -->|"activates"| PEROXISOME
    Ataxia["Ataxia"]
    GRP78 -->|"interacts with"| Ataxia
    Melatonin["Melatonin"]
    GRP78 -->|"activates"| Melatonin
    CARDIOMYOCYTES["CARDIOMYOCYTES"]
    GRP78 -->|"activates"| CARDIOMYOCYTES
    Chaperone["Chaperone"]
    GRP78 -->|"inhibits"| Chaperone
    HSP27["HSP27"]
    GRP78 -->|"expressed in"| HSP27
    LRRK2["LRRK2"]
    LRRK2 -->|"activates"| GRP78
    Pi3K["Pi3K"]
    Pi3K -->|"activates"| GRP78

Outgoing (27)

Target	Relation	Type	Str
PERK	interacts_with	protein	0.85
ALS	associated_with	disease	0.60
multiple sclerosis	associated_with	disease	0.60
VPS34	activates	protein	0.50
IFNG	activates	gene	0.50
cancer	activates	disease	0.50
MAPK	activates	gene	0.50
OXIDATIVE PHOSPHORYLATION	activates	pathway	0.50
MTORC1	activates	concept	0.50
Stem Cell	activates	cell_type	0.50
Epithelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
Dendritic Cell	activates	cell_type	0.50
CYP1A1	activates	concept	0.50
DNA DAMAGE	activates	concept	0.50
COLORECTAL CANCER	activates	disease	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
Reactive Oxygen Species	activates	process	0.50
RAPAMYCIN	activates	concept	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
PEROXISOME	activates	concept	0.50
Ataxia	interacts_with	disease	0.50
CARDIOMYOCYTES	activates	concept	0.50
Chaperone	inhibits	pathway	0.50
HSP27	expressed_in	protein	0.50

Incoming (57)

Source	Relation	Type	Str
VEGF-B	interacts_with	protein	0.85
ATG2A-G433A	upregulates	variant	0.85
LRRK2	activates	gene	0.50
Pi3K	activates	pathway	0.50
TFEB	activates	protein	0.50
EGFR	activates	gene	0.50
EIF2A	activates	protein	0.50
Autophagy	activates	process	0.50
STING1	activates	protein	0.50
RICTOR	activates	gene	0.50
EIF2AK3	activates	gene	0.50
DDIT3	activates	gene	0.50
MLKL	activates	gene	0.50
OPTN	activates	gene	0.50
STAT3	activates	gene	0.50
DEPTOR	activates	gene	0.50
RIPK1	activates	gene	0.50
FIP200	activates	gene	0.50
GABA	activates	gene	0.50
ERN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
mTOR	activates	entity	0.50
PPARG	activates	gene	0.50
GRB2	activates	gene	0.50
RPS6KB1	activates	gene	0.50
HSPA5	activates	gene	0.50
RHEB	activates	gene	0.50
PIK3C3	activates	gene	0.50
RPTOR	activates	gene	0.50
MAP1LC3A	activates	gene	0.50
TFE3	activates	gene	0.50
RB1CC1	activates	gene	0.50
MAPK14	activates	gene	0.50
HMGB1	activates	gene	0.50
MAVS	activates	gene	0.50
MLST8	activates	gene	0.50
NBR1	activates	gene	0.50
RIBOSOMAL PROTEIN S6	activates	protein	0.50
OPTINEURIN	activates	protein	0.50
HSP70	activates	protein	0.50
ENDOPHILIN	activates	protein	0.50
P38 Mapk	activates	pathway	0.50
GABARAP	activates	protein	0.50
mogad	inhibits	disease	0.50
cardiomyopathy	activates	disease	0.50
PERK	activates	gene	0.50
VEGF	activates	gene	0.50
PERK	inhibits	gene	0.50
VEGF	inhibits	gene	0.50
Sod1	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GRP78

Understanding Entity Pages

Summary

Wiki Pages (20)

GBA1→GCase→Lysosome→PD Causal Chain

Metabolomic Alterations in PSP

tudca-udca-neurodegeneration

er-stress-neurodegeneration

Unfolded Protein Response (UPR)

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

Neurotrophic Factors in Neurodegeneration

Endoplasmic Reticulum Stress Comparison Across Neurodegenerative Diseases

PKR Pathway in Neurodegeneration

endoplasmic-reticulum-stress

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

ERP57 (PDIA3) — Protein Disulfide Isomerase Family A Member 3

ATF3 Protein

Sigma-1 Receptor Signaling in Neurodegeneration

ER Stress and Unfolded Protein Response Pathway in Neurodegeneration

PDIA3 - Protein Disulfide Isomerase Family A Member 3

ER-Golgi Secretory Pathway Dysfunction Hypothesis in Parkinson's Disease

CASP12 (Caspase-12)

HNRNPH2 Gene