protein

Erk

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Erk: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2764Connections

0Hypotheses

0Analyses

20Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	ERK
Pathways	APOPTOSIS
GeneCards	ERK
Human Protein Atlas	ERK
Associated Diseases	Alzheimer
Interactions	C1QA, PHAGOCYTOSIS, GRN, DEMENTIA, CTSB, PTEN
KG Connections	215 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Erk["Erk"] -->|"activates"| Dementia["Dementia"]
    style Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Erk["Erk"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    style Frontotemporal_Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Erk["Erk"] -->|"interacts"| Parkinson["Parkinson"]
    style Parkinson fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Erk["Erk"] -->|"interacts"| Stroke["Stroke"]
    style Stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Erk["Erk"] -->|"interacts"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Erk["Erk"] -->|"regulates"| Ferroptosis["Ferroptosis"]
    style Ferroptosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Erk["Erk"] -->|"biomarker for"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    C1QA["C1QA"] -->|"activates"| Erk["Erk"]
    style C1QA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Erk["Erk"]
    style PHAGOCYTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GRN["GRN"] -->|"activates"| Erk["Erk"]
    style GRN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DEMENTIA["DEMENTIA"] -->|"activates"| Erk["Erk"]
    style DEMENTIA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CTSB["CTSB"] -->|"activates"| Erk["Erk"]
    style CTSB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Erk fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (1804)

Target	Relation	Type	Str
Dementia	activates	disease	0.60
Dementia	interacts_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60
Parkinson	interacts_with	disease	0.60
Stroke	interacts_with	disease	0.60
Atherosclerosis	interacts_with	disease	0.60
Dementia	regulates	disease	0.60
Ferroptosis	regulates	disease	0.60
Als	biomarker_for	disease	0.60
Cancer	biomarker_for	disease	0.60
Alzheimer	associated_with	disease	0.60
Cancer	phosphorylates	disease	0.60
Glioblastoma	therapeutic_target	disease	0.60
Autophagy	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Lipid Metabolism	inhibits	pathway	0.55
Mitochondrial Function	regulates	pathway	0.55
Toll-Like Receptor	therapeutic_target	pathway	0.55
Unfolded Protein Response	activates	pathway	0.55

Incoming (960)

Source	Relation	Type	Str
C1QA	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
GRN	activates	gene	0.60
DEMENTIA	activates	gene	0.60
CTSB	activates	gene	0.60
PTEN	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
CATALASE	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Erk

Understanding Entity Pages

Wiki Pages (20)

Parkinson's Disease

NRF2 Oxidative Stress Pathway

NTF4 Protein

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

Growth Factor Therapies

ncam2

Neurotrophin Signaling Pathways in Neurodegeneration

TREM2 Microglial Signaling Pathway in Neurodegeneration

CNTN6 — Contactin 6

CNTN4 — Contactin 4

VEGF/Angiogenesis Pathway in Neurodegeneration

TRA2B Protein - Transformer-2 Beta

nf1-protein

Niemann-Pick Disease Type C (NPC)

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

CNTN3 — Contactin 3