gene

VEGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VEGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1641Connections

5Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Page for VEGF (Vascular Endothelial Growth Factor)

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	VEGF
Aliases	Vascular Endothelial Growth Factor
Function	VEGF serves multiple physiological functions
Primary Expression	hippocampus, motor cortex, cerebellum, cortex, striatum
Pathways	Akt, Amyloid, Apoptosis, Complement, Epigenetic
UniProt ID	[P15692](https://www.uniprot.org/uniprot/P15692)
NCBI Gene ID	7422
GeneCards	VEGF
Human Protein Atlas	VEGF
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	bevacizumab, levodopa, LEVODOPA, QUERCETIN, rapamycin, RAPAMYCIN
Interactions	AB, ACHE, AD, AGING, AHR, AKT
SciDEX Hypotheses	VEGF-family genetic control of vascular-neuronal c
KG Connections	1549 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Alzheimer's Disease VEGF/Angiogenic Signaling and Cerebral Blood Flow Therapy Companies

company · 2020 words

→

VEGF and Angiogenesis Dysregulation in CBS/PSP

mechanism · 1678 words

→

Pericyte PDGFR/VEGFR Modulator Therapy for Neurodegeneration

therapy · 1490 words

→

Pathway Diagram

flowchart TD
    BMAL1["BMAL1
Circadian Regulator"]
    HIF1A["HIF1A
Hypoxia-Inducible Factor"]
    VEGF["VEGF
Vascular Endothelial
Growth Factor"]
    Angiogenesis["Angiogenesis
Blood Vessel Formation"]
    bevacizumab["Bevacizumab
Anti-VEGF Therapy"]
    
    ALS["ALS
Amyotrophic Lateral
Sclerosis"]
    MS["Multiple Sclerosis
Demyelinating Disease"]
    Alzheimer["Alzheimer's Disease
Neurodegeneration"]
    Dementia["Dementia
Cognitive Decline"]
    TBI["Traumatic Brain Injury
Acute Injury"]
    
    Neuropathy["Neuropathy
Nerve Damage"]
    Inflammation["Inflammation
Immune Response"]
    Cancer["Cancer
Malignancy"]
    
    BMAL1 -->|"regulates"| VEGF
    HIF1A -->|"regulates"| VEGF
    VEGF -->|"promotes"| Angiogenesis
    bevacizumab -->|"inhibits"| VEGF
    
    VEGF -->|"activates"| ALS
    VEGF -->|"expressed in"| MS
    VEGF -->|"associated with"| Alzheimer
    VEGF -->|"associated with"| Dementia
    VEGF -->|"protective against"| TBI
    
    VEGF -->|"expressed in"| Neuropathy
    VEGF -->|"associated with"| Inflammation
    VEGF -->|"activates"| Cancer
    
    Angiogenesis -->|"supports"| TBI
    Inflammation -->|"contributes to"| ALS
    Inflammation -->|"contributes to"| MS
    
    style VEGF fill:#006494
    style BMAL1 fill:#4a1a6b
    style HIF1A fill:#4a1a6b
    style bevacizumab fill:#1b5e20
    style Angiogenesis fill:#1b5e20
    style TBI fill:#1b5e20
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Alzheimer fill:#ef5350
    style Dementia fill:#ef5350
    style Inflammation fill:#ef5350
    style Cancer fill:#ef5350
    style Neuropathy fill:#5d4400

Outgoing (760)

Target	Relation	Type	Str
VEGF	encodes	protein	0.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
Als	therapeutic_target	disease	1.00
Ischemia	activates	disease	1.00
Angiogenesis	activates	pathway	1.00
Als	activates	disease	0.95
neovascularization	activates	process	0.91
VASCULAR PERMEABILITY	regulates	process	0.90
colorectal cancer	therapeutic_target	disease	0.90
POEMS Syndrome	involved_in	disease	0.90
endothelial cells	expressed_in	cell_type	0.90
Vascular Remodelling	involved_in	process	0.90
AKT	therapeutic_target	gene	0.90
Mtor	therapeutic_target	pathway	0.90
Angiogenesis	inhibits	pathway	0.90
MTOR	therapeutic_target	gene	0.90
Cognitive Function	involved_in	phenotype	0.85
Colorectal Cancer	therapeutic_target	disease	0.85
Angiogenesis	associated_with	process	0.85
Cancer	activates	disease	0.85
Als	inhibits	disease	0.85
Cancer	inhibits	disease	0.85
Glymphatic Transport	regulates	process	0.85
Inflammation	activates	disease	0.85
Breast Cancer	biomarker_for	disease	0.85
Tumor	inhibits	disease	0.85
Methamphetamine Toxicity	involved_in	mechanism	0.82
ERK	activates	protein	0.82
APOE4	reverses	protein	0.80
ALS	biomarker_for	disease	0.80
Crow-Fukase syndrome	biomarker_for	disease	0.80
PI3K	activates	gene	0.80
IPF	inhibits	disease	0.80
endothelial cells	associated_with	cell_type	0.80
unfolded protein response	participates_in	pathway	0.80
blood-brain barrier	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
endothelial cells	regulates	cell_type	0.80
Tumor Progression	involved_in	process	0.80
Nf-Κb	therapeutic_target	pathway	0.80
Mapk	therapeutic_target	pathway	0.80
GENES	activates	gene	0.80
Apoptosis	activates	pathway	0.80
Wnt	therapeutic_target	pathway	0.80
CANCER	activates	gene	0.80
EGFR	therapeutic_target	gene	0.80
TNF-Α	activates	gene	0.80
Drug Resistance	therapeutic_target	pathway	0.80

Incoming (881)

Source	Relation	Type	Str
VEGF	encodes	gene	0.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
bevacizumab	binds_to	drug	0.95
Irisin	upregulates	protein	0.90
HIF1A	upregulates	gene	0.90
Hu-Loaded Exosomes	downregulates	compound	0.90
BMAL1	regulates	gene	0.90
PI3K	therapeutic_target	gene	0.90
SRPK1	upregulates	protein	0.85
Hypoxia Response Elements	regulates	mechanism	0.85
HIF-1	upregulates	protein	0.85
HIF1A	regulates	gene	0.80
aerobic exercise	activates	process	0.80
APOE4	regulates	protein	0.80
Adrenergic Receptor Blocker	upregulates	drug	0.80
ENDOTHELIAL CELLS	regulates	cell_type	0.80
TEK	phosphorylates	protein	0.80
STAT3	activates	gene	0.80
TNF	activates	gene	0.80
TNF	associated_with	gene	0.74
PDGF	activates	gene	0.70
DRD2	targets	gene	0.70
NOTCH	expresses	gene	0.70
RAGE	regulates	gene	0.70
TNF	transports	gene	0.70
STING	regulates	gene	0.70
BACE1	regulates	gene	0.70
ENDOTHELIAL	enhances	cell_type	0.70
STING	disrupts	gene	0.70
NOTCH	mediates	gene	0.70
RAGE	inhibits	gene	0.70
JAK	inhibits	gene	0.70
ASTROCYTE	mediates	cell_type	0.70
MICROGLIA	associated_with	cell_type	0.70
NLRP3	activates	gene	0.70
ULK1	activates	gene	0.70
TFEB	activates	gene	0.70
IGF1	activates	gene	0.70
ENDOTHELIAL	expresses	cell_type	0.70
NEURONS	activates	cell_type	0.70
HIF1A	inhibits	gene	0.70
MMP9	activates	gene	0.70
GASDERMIN	activates	gene	0.70
BECN1	activates	gene	0.70
ATG5	activates	gene	0.70
HSP90	targets	gene	0.70
P2RX7	activates	gene	0.70
DBH	activates	gene	0.70
NFKB	activates	gene	0.70
SOD1	activates	gene	0.70

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
VEGF-family genetic control of vascular-neuronal coupling in	0.626	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Cell-state stratification is required to resolve VEGF Family	0.612	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Cerebral VSMC foam cells induce pericyte detachment via PDGF	0.473	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α	0.470	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (2)

Scientific analyses that reference this entity

VEGF Family GWAS Signals and Cerebrovascular-Neuronal Coupling in AD Hippocampus

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626

Comparative epigenetic signatures: DNA methylation age acceleration and histone

neurodegeneration | 2026-04-18 | 7 hypotheses Top: 0.620

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

How do VEGF family gene variants identified by single-cell GWAS analysis alter c

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

Investigate shared DNA methylation age acceleration and histone modification pat

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

Related Research

Hypotheses and analyses mentioning VEGF in their description or question text

No additional research found

VEGF

Understanding Entity Pages

Summary

Wiki Pages (17)

VEGF (Vascular Endothelial Growth Factor)

VEGF/Angiogenesis Pathway in Neurodegeneration

VEGF Signaling and Cerebral Angiogenesis in Neurodegeneration

Alzheimer's Disease VEGF/Angiogenic Signaling and Cerebral Blood Flow Therapy Companies

VEGF and Angiogenesis Dysregulation in CBS/PSP

Pericyte PDGFR/VEGFR Modulator Therapy for Neurodegeneration

VEGF Angiogenesis Therapy for Parkinson's Disease

VEGFR1 (FLT1) Protein

Parkinson's Disease VEGF/Angiogenic Signaling Therapy Companies

Vascular Endothelial Growth Factor (VEGF)

VEGF and Angiogenesis Therapy

VEGFA — Vascular Endothelial Growth Factor A

VEGFB Protein

VEGFA Protein - Vascular Endothelial Growth Factor A

FLT1 Protein (VEGF Receptor 1)

VEGFR2 (KDR) Protein

VEGFB Gene