Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VLDL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
VLDL receptor protein in brain development, Reelin signaling, synaptic function, and Alzheimer's disease
| Gene Symbol | VLDL |
| Molecular Weight | 105 kDa |
| Amino Acids | 792 aa |
| Pathways | Cholesterol |
| GeneCards | VLDL |
| Human Protein Atlas | VLDL |
| Known Drugs/Compounds | ceramide |
| Interactions | APOE2, APOE3, APOE4, ERK, LDL, SREBP2 |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
VLDL(["VLDL"])
GPR146["GPR146"]
Cholesterol["Cholesterol"]
SREBP2["SREBP2"]
GPR146 -->|"regulates"| VLDL
VLDL -->|"activates"| Cholesterol
VLDL -->|"activates"| SREBP2
GPR146 -->|"activates"| VLDL
style VLDL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style GPR146 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style Cholesterol fill:#1a3a1a,stroke:#81c784,stroke-width:2px,color:#fff
style SREBP2 fill:#1a1a2e,stroke:#ffd54f,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Triglyceride Transport | mediates | process | 0.85 |
| Ceramide | transports | compound | 0.80 |
| ceramide | interacts_with | compound | 0.80 |
| blood-brain barrier | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| Cholesterol | activates | pathway | 0.50 |
| SREBP2 | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GPR146 | regulates | protein | 0.64 |
| ERK | activates | gene | 0.60 |
| LDL | activates | gene | 0.60 |
| SREBP2 | activates | gene | 0.60 |
| LDL | associated_with | gene | 0.60 |
| LDL | translocates_to | gene | 0.60 |
| APOE2 | interacts_with | gene | 0.55 |
| APOE3 | interacts_with | gene | 0.55 |
| APOE4 | interacts_with | gene | 0.55 |
| GPR146 | activates | gene | 0.50 |
| GPR146 | co_expressed_with | gene | 0.50 |
| LDLR | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||