GPR146

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPR146: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GPR146 (G protein-coupled receptor 146) is a class A GPCR involved in lipid metabolism, energy homeostasis, and brain function. Genetic variants are associated with altered lipid profiles and metabolic syndrome, with emerging links to Alzheimer's disease through metabolic dysfunction.

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graph TD
    GPR146["<b>GPR146</b>"]
    SREBP2["SREBP2"]
    GPR146 -->|"activates"| SREBP2
    ERK["ERK"]
    GPR146 -->|"activates"| ERK
    cholesterol_metabolism(["cholesterol_metabolism"])
    GPR146 -->|"regulates"| cholesterol_metabolism
    Atherosclerosis{"Atherosclerosis"}
    GPR146 -->|"inhibits"| Atherosclerosis
    VLDL["VLDL"]
    GPR146 -->|"regulates"| VLDL
    LDL_C["LDL-C"]
    GPR146 -->|"regulates"| LDL_C
    triglycerides["triglycerides"]
    GPR146 -->|"regulates"| triglycerides
    atherosclerosis{"atherosclerosis"}
    GPR146 -->|"activates"| atherosclerosis
    LDLR["LDLR"]
    GPR146 -->|"inhibits"| LDLR
    Cholesterol(["Cholesterol"])
    GPR146 -->|"regulates"| Cholesterol
    GPR146 -->|"regulates"| SREBP2
    Cholesterol_Metabolism(["Cholesterol Metabolism"])
    GPR146 -->|"inhibits"| Cholesterol_Metabolism
    ERK -->|"regulates"| GPR146
    SREBP2 -->|"regulates"| GPR146
    GENES["GENES"]
    GENES -->|"inhibits"| GPR146
    LDLR -->|"inhibits"| GPR146
    LDL["LDL"]
    LDL -->|"regulates"| GPR146
    AND["AND"]
    AND -->|"inhibits"| GPR146
    style GPR146 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0