concept

SREBP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SREBP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

410Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SREBP2 is a concept in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, Als, Alzheimer. Connected to 105 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SREBP2
Key Genes/Proteins	SCAP, TNF, BACE1, NPC1, GPR146
Related Diseases	Inflammation
Related Pathways	Cholesterol, ERK Signaling Pathway, Inflammasome

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SREBP2["SREBP2"]
    SREBP2 -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    SREBP2 -->|"interacts"| Als["Als"]
    SREBP2 -->|"interacts"| Autoimmune["Autoimmune"]
    SREBP2 -->|"activates"| Carcinoma["Carcinoma"]
    SREBP2 -->|"target for"| Cancer["Cancer"]
    SREBP2 -->|"target for"| Tumor["Tumor"]
    SREBP2 -->|"target for"| Ms["Ms"]
    GPR146["GPR146"] -->|"activates"| SREBP2
    ERK["ERK"] -->|"activates"| SREBP2
    CGAS["CGAS"] -->|"interacts"| SREBP2
    LDLR["LDLR"] -->|"activates"| SREBP2
    NLRP3["NLRP3"] -->|"activates"| SREBP2
    CANCER["CANCER"] -->|"target for"| SREBP2
    CASP3["CASP3"] -->|"target for"| SREBP2

Outgoing (251)

Target	Relation	Type	Str
VLDL Secretion	regulates	process	0.90
Cholesterol	activates	pathway	0.90
BACE1	regulates	protein	0.87
Inflammation	activates	disease	0.85
cholesterol homeostasis	regulates	process	0.85
Lipid Droplet Accumulation	promotes	process	0.80
Cholesterol	regulates	pathway	0.70
Inflammasome	activates	pathway	0.70
Lipid Metabolism	activates	pathway	0.70
Lipid Metabolism	regulates	pathway	0.70
INFLAMMATION	activates	gene	0.70
lipid metabolism	participates_in	pathway	0.70
neurons	expressed_in	cell_type	0.70
Atherosclerosis	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Autoimmune	interacts_with	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Atherosclerosis	activates	disease	0.65
Als	activates	disease	0.65
Autoimmune	activates	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	interacts_with	disease	0.65
Sepsis	activates	disease	0.65
Arrhythmia	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Als	inhibits	disease	0.65
Melanoma	activates	disease	0.65
Infection	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Infection	interacts_with	disease	0.65
Aging	activates	disease	0.65
Senescence	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Parkinson	regulates	disease	0.65
Aging	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Als	contributes_to	disease	0.65
Atherosclerosis	protects_against	disease	0.65

Incoming (159)

Source	Relation	Type	Str
SCAP	interacts_with	gene	0.90
TNF	activates	protein	0.90
NPC1	interacts_with	protein	0.85
ERK Signaling Pathway	activates	pathway	0.85
STING	interacts_with	entity	0.80
ER stress	activates	process	0.80
GPR146	activates	protein	0.72
LDLR	activates	gene	0.70
LDL	regulates	gene	0.70
ERK	activates	protein	0.64
ERK	regulates	gene	0.60
STING	associated_with	gene	0.60
CGAS	interacts_with	gene	0.60
GPR146	regulates	gene	0.60
CGAS	activates	gene	0.60
NPC1	associated_with	gene	0.60
NLRP3	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
MICROGLIA	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOE4	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
NF-ΚB	activates	gene	0.60
APOE	activates	gene	0.60
TAU	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MIR-9-5P	regulates	gene	0.60
ATF6	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
CHOP	interacts_with	gene	0.60
LDLR	inhibits	gene	0.60
GENES	inhibits	gene	0.60
DNA	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
NPC1	transports	gene	0.60
STING	transports	gene	0.60
APOE	regulates	gene	0.60
SREBP1	implicated_in	gene	0.60
ATP	inhibits	gene	0.60
APOE	inhibits	gene	0.60
INFLAMMATION	regulates	gene	0.60
DYNEIN	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
BACE1	inhibits	gene	0.60
GSK3B	inhibits	gene	0.60
TAU	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SREBP2

Understanding Entity Pages

Summary

Wiki Pages (11)

Niemann-Pick Disease Type C (NPC)

Lipid Metabolism Dysregulation in Neurodegeneration

PRKCI

Alpha-Klotho in Neurodegeneration

ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2

SREBP1 Protein

SREBP1 Protein (Sterol Regulatory Element-Binding Protein 1)

LDLR Gene

CHD1 Gene