Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CERAMIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CERAMIDE |
| Key Genes/Proteins | TAU, APP, AMYLOID, APOE |
| Related Diseases | NEUROINFLAMMATION, MITOCHONDRIAL DYSFUNCTION, AXONAL TRANSPORT, INSULIN RESISTANCE, AGING |
| Linked Hypotheses | 7 hypotheses |
Knowledge base pages for this entity
flowchart TD
N0["CERAMIDE"]
N1["SMPD1"]
N1 -->|"produces"| N0
N2["APOE"]
N2 -->|"treats"| N0
N3["NEUROINFLAMMATION"]
N0 -->|"activates"| N3
N4["ENDOPLASMIC RETICULUM"]
N0 -->|"regulates"| N4
N5["TAU"]
N0 -->|"activates"| N5
N6["MITOCHONDRIAL DYSFUNCTION"]
N0 -->|"causes"| N6
N7["APP"]
N0 -->|"inhibits"| N7
N8["AXONAL TRANSPORT"]
N0 -->|"inhibits"| N8
N9["INSULIN RESISTANCE"]
N0 -->|"activates"| N9
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
class N0 concept
class N1 gene
class N2 gene
class N3 phenotype
class N5 protein
class N6 phenotype
class N7 gene
class N8 phenotype
class N9 phenotype| Target | Relation | Type | Str |
|---|---|---|---|
| NEUROINFLAMMATION | activates | phenotype | 0.70 |
| TAU | activates | protein | 0.70 |
| MITOCHONDRIAL DYSFUNCTION | causes | phenotype | 0.70 |
| APP | inhibits | gene | 0.70 |
| AXONAL TRANSPORT | inhibits | phenotype | 0.70 |
| NEUROINFLAMMATION | biomarker_for | phenotype | 0.70 |
| INSULIN RESISTANCE | activates | phenotype | 0.70 |
| INSULIN RESISTANCE | regulates | phenotype | 0.70 |
| AMYLOID | destabilizes | protein | 0.70 |
| AGING | activates | phenotype | 0.70 |
| AGING | regulates | phenotype | 0.70 |
| CTSD | regulates | gene | 0.65 |
| PINK1 | inhibits | gene | 0.65 |
| PINK1 | interacts_with | gene | 0.65 |
| PROTEIN AGGREGATION | activates | phenotype | 0.65 |
| TAU PHOSPHORYLATION | causes | phenotype | 0.65 |
| SPHINGOMYELIN | inhibits | phenotype | 0.65 |
| NLRP3 INFLAMMASOME | produces | pathway | 0.65 |
| SPHINGOMYELIN | treats | phenotype | 0.65 |
| ALPHA-SYNUCLEIN | regulates | protein | 0.65 |
| AMYLOID | causes | protein | 0.65 |
| INSULIN RESISTANCE | produces | phenotype | 0.65 |
| NEURODEGENERATION | regulates | disease | 0.65 |
| NEURODEGENERATION | interacts_with | disease | 0.65 |
| ALZHEIMER'S DISEASE | causes | disease | 0.65 |
| LYSOSOMAL DYSFUNCTION | activates | phenotype | 0.65 |
| NEURODEGENERATION | activates | disease | 0.65 |
| ALZHEIMER'S DISEASE | interacts_with | disease | 0.65 |
| OXIDATIVE STRESS | interacts_with | phenotype | 0.65 |
| NEUROINFLAMMATION | interacts_with | phenotype | 0.65 |
| PYROPTOSIS | activates | phenotype | 0.65 |
| COGNITIVE DECLINE | expressed_in | phenotype | 0.60 |
| AGING | expressed_in | phenotype | 0.60 |
| OBESITY | implicated_in | disease | 0.55 |
| ALZHEIMER'S DISEASE | expressed_in | disease | 0.55 |
| LIPID RAFT | implicated_in | organelle | 0.55 |
| NLRP3 INFLAMMASOME | implicated_in | pathway | 0.55 |
| ALZHEIMER'S DISEASE | implicated_in | disease | 0.55 |
| SPHINGOLIPID | co_discussed | entity | 0.50 |
| MS | co_discussed | entity | 0.50 |
| MULTIPLE SCLEROSIS | co_discussed | entity | 0.50 |
| GENE EXPRESSION | interacts_with | concept | 0.50 |
| Sphingolipid | interacts_with | pathway | 0.50 |
| Reactive Oxygen Species | inhibits | process | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| SGMS1 | inhibits | concept | 0.50 |
| Sphingolipid | regulates | pathway | 0.50 |
| ISCHEMIC | interacts_with | concept | 0.50 |
| ISCHEMIC STROKE | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | treats | gene | 0.70 |
| APOE | activates | gene | 0.70 |
| APOE | inhibits | gene | 0.70 |
| ENDOPLASMIC RETICULUM STRESS | causes | phenotype | 0.70 |
| APP | treats | gene | 0.70 |
| CANCER | destabilizes | disease | 0.70 |
| OXIDATIVE STRESS | activates | phenotype | 0.70 |
| AMYLOID | produces | protein | 0.70 |
| APP | activates | gene | 0.70 |
| APOE | causes | gene | 0.70 |
| APOE | regulates | gene | 0.70 |
| GOLGI APPARATUS | regulates | organelle | 0.65 |
| MITOPHAGY | exacerbates | phenotype | 0.65 |
| MITOPHAGY | interacts_with | phenotype | 0.65 |
| FINGOLIMOD | encodes | drug | 0.65 |
| GBA | encodes | gene | 0.65 |
| INSULIN RESISTANCE | interacts_with | phenotype | 0.65 |
| AKT | regulates | gene | 0.65 |
| MINOCYCLINE | activates | drug | 0.65 |
| LRRK2 | regulates | gene | 0.65 |
| APOE | expressed_in | gene | 0.60 |
| OXIDATIVE STRESS | degrades | phenotype | 0.60 |
| SPHINGOMYELIN | participates_in | phenotype | 0.55 |
| IL-10 | activates | protein | 0.50 |
| CERS2 | interacts_with | gene | 0.50 |
| IL-10 | interacts_with | protein | 0.50 |
| inflammation | interacts_with | pathway | 0.50 |
| inflammation | regulates | pathway | 0.50 |
| CERS2 | regulates | gene | 0.50 |
| ACSL4 | inhibits | gene | 0.50 |
| TFR1 | inhibits | gene | 0.50 |
| GPX4 | inhibits | gene | 0.50 |
| FTH1 | inhibits | protein | 0.50 |
| ferroptosis | inhibits | phenotype | 0.50 |
| apoptosis | activates | process | 0.50 |
| ALZHEIMER | associated_with | gene | 0.50 |
| Alzheimer'S Disease | associated_with | disease | 0.50 |
| CERS6 | activates | gene | 0.50 |
| CERS2 | activates | gene | 0.50 |
| asah1 | activates | gene | 0.50 |
| STROKE | interacts_with | gene | 0.50 |
| SERINE PALMITOYLTRANSFERASE | inhibits | protein | 0.50 |
| BACE1 | activates | gene | 0.50 |
| ALZHEIMER | activates | gene | 0.50 |
| Alzheimer'S Disease | activates | disease | 0.50 |
| AMYLOID | activates | gene | 0.50 |
| apoptosis | regulates | process | 0.50 |
| Cholesterol | regulates | pathway | 0.50 |
| NLRP3 | activates | protein | 0.50 |
| inflammation | activates | pathway | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||