Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about YME1L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
YME1L1 (YME1 Like 1) is a mitochondrial inner membrane AAA protease essential for protein quality control, mitochondrial dynamics, and neuronal survival. Mutations cause hereditary spastic paraplegia and optic atrophy.
| Gene Symbol | YME1L1 |
| Full Name | YME1 Like 1 ATPase (mitochondrial inner membrane protease) |
| Aliases | YME1L, ATP-dependent protease YME1L |
| Chromosome | 10p11.23 |
| Protein Type | Protease |
| Function | is a critical mitochondrial inner membrane protease that belongs to the AAA (ATPases Associated with various cellular Activities) family of proteins. |
| Primary Expression | Ubiquitous (high in brain, heart, muscle, liver) |
| Molecular Weight | 84 kDa |
| Amino Acids | 757 aa |
| Pathways | Differentiation |
| UniProt ID | Q9Y4K0 |
| NCBI Gene ID | 10762 |
| Ensembl ID | ENSG00000135547 |
| OMIM | 607472 |
| GeneCards | YME1L1 |
| Human Protein Atlas | YME1L1 |
| Associated Diseases | neurodegeneration |
| Interactions | MITOCHONDRIA, SIRT3, OPA1, SENP1, CHCHD2, CLPP |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
YME1L1(["YME1L1"])
Als["Als"]
MITOCHONDRIA(["MITOCHONDRIA"])
Differentiation["Differentiation"]
AMPK(["AMPK"])
SIRT3(["SIRT3"])
OPA1(["OPA1"])
SENP1(["SENP1"])
neurodegeneration["neurodegeneration"]
YME1L1 -->|"activates"| Als
YME1L1 -->|"activates"| MITOCHONDRIA
YME1L1 -->|"activates"| Differentiation
AMPK -->|"activates"| YME1L1
SIRT3 -->|"activates"| YME1L1
OPA1 -->|"activates"| YME1L1
SENP1 -->|"activates"| YME1L1
YME1L1 -->|"implicated in"| neurodegeneration
style YME1L1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| MITOCHONDRIA | activates | gene | 0.60 |
| Differentiation | activates | pathway | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||