protein

OPA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

793Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

OPA1 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 309 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	OPA1
Full Name	Optic Atrophy 1
Aliases	MTOA, ATL3 (related), KIAA0057
Chromosome	3q29
Protein Type	Protein
Function	OPA1 is a nuclear-encoded mitochondrial protein that functions as a large GTPase mediating mitochondrial inner membrane fusion.
Subcellular Localization	the inner mitochondrial membrane. It is essential for mitochondrial inner membrane fusion, cristae maintenance, and mito
Molecular Weight	120kDa
Amino Acids	300 aa
Pathways	Apoptosis, Lysosomal Degradation, Mitochondrial Function, Mitophagy, Mtor
UniProt ID	O60313
NCBI Gene ID	4976
GeneCards	OPA1
Human Protein Atlas	OPA1
Protein	OPA1 protein
Associated Diseases	ALS, Aging, Alzheimer, CHARCOT-MARIE-TOOTH, Cancer
Interactions	MFN1, AKT, VDAC1, MFN2, FOXO3, MLKL
KG Connections	793 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: OPA1 — AlphaFold O60313 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OPA1["OPA1"]
    OPA1 -->|"activates"| Als["Als"]
    OPA1 -->|"activates"| Cancer["Cancer"]
    OPA1 -->|"regulates"| Ms["Ms"]
    OPA1 -->|"expressed in"| Alzheimer["Alzheimer"]
    OPA1 -->|"expressed in"| Dementia["Dementia"]
    OPA1 -->|"activates"| Fibrosis["Fibrosis"]
    OPA1 -->|"activates"| Ischemia["Ischemia"]
    NRF1["NRF1"] -->|"activates"| OPA1
    PPARGC1A["PPARGC1A"] -->|"target for"| OPA1
    SIRT1["SIRT1"] -->|"target for"| OPA1
    DNM1L["DNM1L"] -->|"target for"| OPA1
    DRP1["DRP1"] -->|"activates"| OPA1
    PRKAA1["PRKAA1"] -->|"target for"| OPA1
    JUN["JUN"] -->|"target for"| OPA1
    VDAC1["VDAC1"] -->|"activates"| OPA1
    KRAS["KRAS"] -->|"activates"| OPA1

Outgoing (434)

Target	Relation	Type	Str
Mitochondrial fusion	activates	process	0.95
Mitochondrial Dynamics	involved_in	process	0.95
Mitochondrial Fusion	involved_in	process	0.90
mitochondrial dynamics	participates_in	pathway	0.90
Mitochondrial Fusion	mediates	process	0.88
Mitochondrial Fusion	promotes	process	0.85
Als	activates	disease	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
DRP1	activates	gene	0.80
Als	expressed_in	disease	0.75
Mtor	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.70
MITOCHONDRIA	activates	gene	0.70
Differentiation	activates	pathway	0.70
Mitochondrial Function	implicated_in	pathway	0.70
Apoptosis	implicated_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
hippocampus	expressed_in	brain_region	0.70
TDP-43	regulates	gene	0.65
Cancer	activates	disease	0.65
Als	protects_against	disease	0.65
Senescence	associated_with	disease	0.65
Ms	regulates	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Fibrosis	activates	disease	0.65
Ms	activates	disease	0.65
Ischemia	activates	disease	0.65
Heart Failure	regulates	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cardiovascular	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Hypertension	regulates	disease	0.65
Ischemia	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Aging	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Neuropathy	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65

Incoming (359)

Source	Relation	Type	Str
Ros	cleaves	process	0.85
TAU	downregulates	protein	0.85
PM10	downregulates	compound	0.85
Aging	downregulates	process	0.85
MFN2	inhibits	gene	0.80
MITOPHAGY	activates	gene	0.80
MFN1	inhibits	gene	0.70
SIRT3	activates	gene	0.70
Copper	inhibits	drug	0.70
Zn	activates	drug	0.70
APOPTOSIS	implicated_in	gene	0.70
AMPK	inhibits	gene	0.70
ATP	inhibits	gene	0.70
CHCHD10	regulates	gene	0.65
CHCHD10	causes	gene	0.65
NEURONS	destabilizes	cell_type	0.65
NEURONS	stabilizes	cell_type	0.65
NRF1	activates	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
SIRT1	therapeutic_target	gene	0.60
DNM1L	therapeutic_target	gene	0.60
DRP1	activates	gene	0.60
PRKAA1	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
VDAC1	activates	gene	0.60
DNM1L	activates	gene	0.60
MFN1	activates	gene	0.60
DRP1	associated_with	gene	0.60
P62	protects_against	gene	0.60
PARKIN	protects_against	gene	0.60
KEAP1	protects_against	gene	0.60
DNM1L	regulates	gene	0.60
AKT	activates	gene	0.60
MFN2	regulates	gene	0.60
MMP9	associated_with	gene	0.60
RELA	expressed_in	gene	0.60
BCL2	associated_with	gene	0.60
FUNDC1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
TNF	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
MFF	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
SESN2	associated_with	gene	0.60
STX17	associated_with	gene	0.60
MAVS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

OPA1

Understanding Entity Pages

Summary

Wiki Pages (21)

OPA1 — Optic Atrophy 1

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Mitophagy Pathway in Neurodegeneration

Coenzyme Q10 for Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

Insulin Signaling in Parkinson's Disease

Motor Neuron Disease (MND)

mitochondrial-dynamics-dysfunction-parkinsons

DDX3X Gene

Mitochondria

Mitophagy Pathway in Neurodegeneration

Mitochondrial Dysfunction in Progressive Supranuclear Palsy

RICTOR Protein

YME1L1 Gene

Mitochondria in Neurodegeneration

CNTFR Gene

Protein O-GlcNAcylation Pathway in Neurodegeneration

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease