gene

HSPD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

220Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for HSPD1 Gene - Heat Shock Protein Family D Member 1

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🧬 Gene Info

Gene Symbol	HSPD1
Full Name	Heat Shock Protein Family D Member 1
Aliases	Page for HSPD1 Gene
Chromosome	2q33.1
Protein Type	Chaperone
Function	HSPD1/Hsp60 is a key mitochondrial chaperone
Primary Expression	all tissues with high energy requirements:
Pathways	Mitophagy
UniProt ID	P10828
NCBI Gene ID	3329
Ensembl ID	ENSG00000134375
OMIM	118190
GeneCards	HSPD1
Human Protein Atlas	HSPD1
Associated Diseases	Aging, Carcinoma
Interactions	COX4I1, GRIA2, PRKN, CALCOCO2, MFN2, MFF
KG Connections	220 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPD1 — AlphaFold P10828 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HSPD1["HSPD1"]
    HSPD1 -->|"activates"| Aging["Aging"]
    HSPD1 -->|"activates"| Cardiovascular["Cardiovascular"]
    HSPD1 -->|"contributes to"| Ms["Ms"]
    HSPD1 -->|"contributes to"| Cancer["Cancer"]
    HSPD1 -->|"expressed in"| Carcinoma["Carcinoma"]
    HSPD1 -->|"inhibits"| Als["Als"]
    HSPD1 -->|"inhibits"| Tumor["Tumor"]
    HSPD1 -->|"regulates"| Heart_Failure["Heart Failure"]
    MAP1LC3B["MAP1LC3B"] -.biomarker for.-> HSPD1
    CKB["CKB"] -->|"interacts"| HSPD1
    MYO7A["MYO7A"] -->|"activates"| HSPD1
    OPTN["OPTN"] -->|"activates"| HSPD1
    PARKIN["PARKIN"] -->|"activates"| HSPD1
    PINK1["PINK1"] -->|"activates"| HSPD1
    XBP1["XBP1"] -->|"activates"| HSPD1
    ATF3["ATF3"] -->|"activates"| HSPD1
    TOMM20["TOMM20"] -->|"activates"| HSPD1

Outgoing (140)

Target	Relation	Type	Str
Aging	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	expressed_in	disease	0.65
Ms	contributes_to	disease	0.65
Cancer	contributes_to	disease	0.65
Carcinoma	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Heart Failure	regulates	disease	0.65
Ms	inhibits	disease	0.65
Lymphoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Aging	implicated_in	disease	0.65
Carcinoma	implicated_in	disease	0.65
COX4I1	activates	gene	0.60
GRIA2	activates	gene	0.60
PRKN	activates	gene	0.60
MAP1LC3B	contributes_to	gene	0.60
CALCOCO2	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	regulates	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	regulates	gene	0.60
TIMM50	regulates	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	regulates	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	regulates	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60

Incoming (80)

Source	Relation	Type	Str
MAP1LC3B	biomarker_for	gene	0.80
CKB	interacts_with	gene	0.80
MYO7A	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
OPTN	activates	gene	0.60
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
XBP1	activates	gene	0.60
ATF3	activates	gene	0.60
TOMM20	activates	gene	0.60
PTEN	activates	gene	0.60
USP30	activates	gene	0.60
FOXO3	activates	gene	0.60
GRIA2	activates	gene	0.60
PRKN	activates	gene	0.60
COX4I1	activates	gene	0.60
PTEN	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
TOMM20	interacts_with	gene	0.60
TIMM23	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
UBIQUITIN	activates	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
HSP60	activates	entity	0.60
OPTINEURIN	activates	gene	0.60
AIFM1	activates	gene	0.60
ATP5A1	activates	gene	0.60
CALCOCO2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HSPD1

Understanding Entity Pages

Summary

Wiki Pages (19)

HSPD1 Gene - Heat Shock Protein Family D Member 1

Mitochondrial Unfolded Protein Response in Neurodegeneration

HSPE1 — Heat Shock Protein Family E Member 1

TIMM23 — Translocase of Inner Mitochondrial Membrane 23

ECSIT — Evolutionarily Conserved Signaling Intermediate in Toll Pathways

GRIA2 Gene

Molecular Chaperones in Neurodegeneration

Heat Shock Proteins

HSP60 (Heat Shock Protein 60)

HSPA6

hspd1-protein

DNAJC10 Gene

HSPA1L Gene

HSPD2 Protein

HSPD2 Gene

Hsp60 Protein

CKB Gene