gene

SENP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SENP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

80Connections

0Hypotheses

0Analyses

50Outgoing

17Incoming

Summary

SENP1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with Als, Cancer, Colorectal Cancer. Connected to 47 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SENP1
Full Name	SUMO Specific Peptidase 1
Aliases	Page for SENP1 Protein
Chromosome	2q33.1
Protein Family	SENP family (SUMO proteases)
Protein Type	Protease
Function	is a cysteine protease that catalyzes deSUMOylation—the removal of SUMO (Small Ubiquitin-Like Modifier) proteins from target substrates.
Molecular Weight	71 kDa
Amino Acids	482 aa
Pathways	Apoptosis, Mitophagy, Mtor, Oxidative Stress
UniProt ID	[Q9Y5W4](https://www.uniprot.org/uniprot/Q9Y5W4)
Ensembl ID	ENSG00000142405
GeneCards	SENP1
Human Protein Atlas	SENP1
N-terminal domain	Regulatory, determines substrate specificity
Associated Diseases	neurodegeneration
Interactions	MANF, UBIQUITIN, NRF1, OPA1, MFN2, TFAM
KG Connections	80 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SENP1["<b>SENP1</b>"]
    MANF["MANF"]
    SENP1 -->|"modifies"| MANF
    Als{"Als"}
    SENP1 -->|"regulates"| Als
    Cancer{"Cancer"}
    SENP1 -->|"regulates"| Cancer
    Tumor{"Tumor"}
    SENP1 -->|"regulates"| Tumor
    Fibrosis{"Fibrosis"}
    SENP1 -->|"activates"| Fibrosis
    Ischemia{"Ischemia"}
    SENP1 -->|"activates"| Ischemia
    Inflammation{"Inflammation"}
    SENP1 -->|"activates"| Inflammation
    PARKIN["PARKIN"]
    SENP1 -->|"regulates"| PARKIN
    UBIQUITIN["UBIQUITIN"]
    SENP1 -->|"regulates"| UBIQUITIN
    MITOPHAGY["MITOPHAGY"]
    SENP1 -->|"regulates"| MITOPHAGY
    CANCER["CANCER"]
    SENP1 -->|"regulates"| CANCER
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    SENP1 -->|"regulates"| OXIDATIVE_STRESS
    PIN1["PIN1"]
    PIN1 -->|"binds"| SENP1
    MFN1["MFN1"]
    MFN1 -->|"inhibits"| SENP1
    style SENP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (63)

Target	Relation	Type	Str
MANF	de-SUMOylates	protein	0.90
MANF	modulates	protein	0.85
MANF	modifies	protein	0.80
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Fibrosis	activates	disease	0.65
Ischemia	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	inhibits	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Leukemia	activates	disease	0.65
PARKIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
PRKN	regulates	gene	0.60
MANF	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
SUMO1	activates	gene	0.60
SIRT3	activates	gene	0.60
SOD2	activates	gene	0.60
YME1L1	activates	gene	0.60
HIF1A	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
IGF2BP3	activates	gene	0.60
AKT	activates	gene	0.60
EGFR	activates	gene	0.60
Sumo	activates	protein	0.60
MITOPHAGY	regulates	gene	0.60
CANCER	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
Oxidative Stress	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AMPK	activates	gene	0.60
Apoptosis	activates	pathway	0.60
MITOCHONDRIA	activates	gene	0.60
Differentiation	activates	pathway	0.60
CANCER	activates	gene	0.60
Chemoresistance	activates	pathway	0.60
Mtor	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60

Incoming (17)

Source	Relation	Type	Str
PIN1	binds	protein	0.80
MFN1	inhibits	gene	0.60
SIRT3	activates	gene	0.60
OPA1	activates	gene	0.60
VHL	activates	gene	0.60
HDAC2	activates	gene	0.60
IGF2BP3	activates	gene	0.60
AKT	activates	gene	0.60
EGFR	activates	gene	0.60
MTOR	regulates	gene	0.60
AKT	regulates	gene	0.60
HDAC2	interacts_with	gene	0.60
AMPK	activates	gene	0.60
RNA	expressed_in	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
mTOR	regulates	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SENP1

Understanding Entity Pages

Summary

Wiki Pages (18)

SENP1 — SUMO Specific Peptidase 1

cbs-psp-daily-action-plan

Protein SUMOylation Pathway in Neurodegeneration

Tau Post-Translational Modifications in 4R-Tauopathies

UBE2I Protein

sumoylation

NEUROD2 Gene

SUMOylation in Neurodegeneration

CRMP2 Phosphorylation State Modulation Therapy for Neurodegeneration

SENP2 Protein - SUMO Specific Peptidase 2

SUMO2 — Small Ubiquitin-Like Modifier 2

SUMO1 Protein - Small Ubiquitin-Like Modifier 1

YME1L1 Protein

SENP1 Protein - SUMO Specific Peptidase 1

PIN1 — Peptidyl-prolyl cis-trans Isomerase NIMA-Interacting 1

SENP2 — SUMO Specific Peptidase 2