gene

CHCHD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHCHD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

194Connections

0Hypotheses

0Analyses

50Outgoing

48Incoming

Summary

CHCHD2 encodes a mitochondrial protein linked to Parkinson's disease. Loss-of-function mutations cause autosomal dominant PD with alpha-synuclein pathology.

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🧬 Gene Info

Gene Symbol	CHCHD2
Full Name	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2
Chromosome	7p13
Protein Family	Coiled-Coil-Helix-Coiled-Coil-Helix (CHCHD) domain proteins
Protein Type	Protein
Function	is a small mitochondrial protein that plays critical roles in mitochondrial function, cellular metabolism, and Parkinson's disease (PD) pathogenesis.
Primary Expression	dopaminergic neurons of the substantia nigra pars compacta, explaining the selective vulnerability of these neurons in PD
Subcellular Localization	the intermembrane space, where it plays important roles in mitochondrial function, particularly in response to oxidative
Molecular Weight	26 kDa
Amino Acids	182 aa
Pathways	Mitophagy
UniProt ID	Search UniProt
GeneCards	CHCHD2
Human Protein Atlas	CHCHD2
Coiled-coil helix domain	Mediates protein-protein interactions
Associated Diseases	ALS, Aging, Amyotrophic Lateral Sclerosis, Dementia, Kii ALS/PDC
Interactions	GPX4, LRRK2, SNCA, TDP43, FBXO7, JNK
KG Connections	194 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CHCHD2 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHCHD2["<b>CHCHD2</b>"]
    Parkinson{"Parkinson"}
    CHCHD2 -->|"associated with"| Parkinson
    Ms{"Ms"}
    CHCHD2 -->|"associated with"| Ms
    Neurodegeneration{"Neurodegeneration"}
    CHCHD2 -->|"associated with"| Neurodegeneration
    CHCHD2 -->|"regulates"| Parkinson
    Als{"Als"}
    CHCHD2 -->|"therapeutic target"| Als
    CHCHD2 -->|"regulates"| Neurodegeneration
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    CHCHD2 -->|"protects against"| OXIDATIVE_STRESS
    GPX4["GPX4"]
    CHCHD2 -->|"inhibits"| GPX4
    Ferroptosis(["Ferroptosis"])
    CHCHD2 -->|"associated with"| Ferroptosis
    Oxidative_Stress(["Oxidative Stress"])
    CHCHD2 -->|"protects against"| Oxidative_Stress
    SNCA["SNCA"]
    CHCHD2 -->|"therapeutic target"| SNCA
    PRKN["PRKN"]
    CHCHD2 -->|"regulates"| PRKN
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| CHCHD2
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"associated with"| CHCHD2
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"associated with"| CHCHD2
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    MITOCHONDRIAL_DYSFUNCTION -->|"inhibits"| CHCHD2
    PARKINSON_S_DISEASE -->|"regulates"| CHCHD2
    NEURODEGENERATION -->|"regulates"| CHCHD2
    PARKIN["PARKIN"]
    PARKIN -->|"regulates"| CHCHD2
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| CHCHD2
    LRRK2["LRRK2"]
    LRRK2 -->|"therapeutic target"| CHCHD2
    MITOCHONDRIAL_DYSFUNCTION -->|"therapeutic target"| CHCHD2
    PTEN["PTEN"]
    PTEN -->|"regulates"| CHCHD2
    style CHCHD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (146)

Target	Relation	Type	Str
Kii ALS/PDC	associated_with	disease	0.95
Kii Als/Pdc	associated_with	disease	0.95
Mitochondria	involved_in	cell_type	0.90
oxidative stress response	participates_in	pathway	0.90
Mitochondrial Morphology	regulates	phenotype	0.85
Mitochondrial Metabolism	regulates	process	0.85
Mitochondrial Health	involved_in	phenotype	0.85
Motor Cortex	expressed_in	cell_type	0.75
Spinal Cord	expressed_in	cell_type	0.75
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Parkinson	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Parkinson	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
GPX4	inhibits	gene	0.60
SNCA	therapeutic_target	gene	0.60
PRKN	regulates	gene	0.60
PINK1	regulates	gene	0.60
PTEN	regulates	gene	0.60
PARKIN	regulates	gene	0.60
LRRK2	therapeutic_target	gene	0.60
TDP-43	associated_with	gene	0.60
TAU	associated_with	gene	0.60
PINK1	contributes_to	gene	0.60
HTT	associated_with	gene	0.60
LRRK2	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
SNCA	associated_with	gene	0.60
cardiovascular disease	associated_with	disease	0.60
TDP43	interacts_with	gene	0.60
neurodegeneration	protects_against	disease	0.60
neurodegeneration	associated_with	disease	0.60
FBXO7	activates	gene	0.60
FBXO7	interacts_with	gene	0.60
JNK	activates	gene	0.60
CLPP	activates	gene	0.60
HSPA9	activates	gene	0.60
HSPD1	activates	gene	0.60
YME1L1	activates	gene	0.60
GBA1	causes	gene	0.60
LRRK2	causes	gene	0.60
PARK7	causes	gene	0.60
PINK1	causes	gene	0.60

Incoming (48)

Source	Relation	Type	Str
PARKIN	regulates	gene	0.60
LRRK2	therapeutic_target	gene	0.60
PTEN	regulates	gene	0.60
PRKN	regulates	gene	0.60
SNCA	therapeutic_target	gene	0.60
PINK1	regulates	gene	0.60
TAU	associated_with	gene	0.60
TDP-43	associated_with	gene	0.60
PRKN	contributes_to	gene	0.60
PARKIN	contributes_to	gene	0.60
CHCHD10	associated_with	gene	0.60
CHCHD10	interacts_with	gene	0.60
CHCHD10	protects_against	gene	0.60
CHCHD10	causes	gene	0.60
CHCHD10	co_expressed_with	gene	0.60
CHCHD10	implicated_in	gene	0.60
AKT	activates	gene	0.60
ANXA11	causes	gene	0.60
CCNF	causes	gene	0.60
ANXA11	associated_with	gene	0.60
CCNF	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
PTEN-INDUCED PUTATIVE KINASE 1	regulates	gene	0.60
AND	therapeutic_target	gene	0.60
MITOCHONDRIA	therapeutic_target	gene	0.60
PARKINSON	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
ASTROCYTE	implicated_in	gene	0.60
ALS	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
ASTROCYTES	implicated_in	gene	0.60
AND	inhibits	gene	0.60
DEMENTIA	associated_with	gene	0.60
ASTROCYTE	inhibits	gene	0.60
PARKINSON	associated_with	gene	0.60
ASTROCYTES	inhibits	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
ALS	expressed_in	gene	0.60
ALS	implicated_in	gene	0.60
ALS	protects_against	gene	0.60
ALS	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHCHD2

Understanding Entity Pages

Summary

Wiki Pages (20)

CHCHD2 - Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2

Spinal Cord Dorsal Horn Neurons

Gene-Mechanism-Therapy Causal Chains

Huntingtin Protein (HTT)

CHCHD2 Protein

lewy-body-pathogenesis

CHCHD5 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 5

MDS 2026 — PD Genetic and Molecular Mechanisms

CHCHD9 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 9

CHCHD10 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10

CHCHD10 Mitochondrial Dysfunction — ALS/FTD Causal Chain

chchd2-protein

CHCHD6 Protein

CHCHD3 Protein

What to Work On — NeuroWiki Decision Guide

CHCHD3 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3

CHCHD10 Protein (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10)

MiD50 Protein