gene

ZDHHC12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZDHHC12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

5Outgoing

4Incoming

Summary

ZDHHC12 encodes a palmitoyltransferase enzyme involved in protein S-acylation, with critical roles in neuronal function and implications for neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	ZDHHC12
Full Name	Zinc Finger DHHC-Type Containing 12
Chromosome	9q34.3
Protein Family	DHHC palmitoyltransferase family
Protein Type	Transferase
Function	encodes a member of the zinc finger DHHC-type palmitoyltransferase (PAT) family, a group of enzymes that catalyze the S-acylation (palmitoylation) of proteins.
Molecular Weight	~41 kDa
Amino Acids	360 aa
Exons	6
Pathways	Apoptosis, Inflammasome, Nlrp3 Inflammasome
UniProt ID	Q9NPA8
NCBI Gene ID	197407
Ensembl ID	ENSG00000159593
OMIM	614539
GeneCards	ZDHHC12
Human Protein Atlas	ZDHHC12
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ASC, APOPTOSIS, AND
KG Connections	9 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ZDHHC12 — AlphaFold Q9NPA8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ZDHHC12 (Zinc Finger DHHC-Type Containing 12)

gene · 2249 words

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Genes

index · 271 words

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Pathway Diagram

graph TD
    ZDHHC12["<b>ZDHHC12</b>"]
    APOPTOSIS["APOPTOSIS"]
    ZDHHC12 -->|"activates"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    ZDHHC12 -->|"activates"| Apoptosis
    Inflammasome(["Inflammasome"])
    ZDHHC12 -->|"activates"| Inflammasome
    neurodegeneration["neurodegeneration"]
    ZDHHC12 -->|"implicated in"| neurodegeneration
    ASC["ASC"]
    ASC -->|"activates"| ZDHHC12
    NLRP3["NLRP3"]
    NLRP3 -->|"regulates"| ZDHHC12
    style ZDHHC12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
ASC	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Nlrp3 Inflammasome	activates	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
ASC	activates	gene	0.60
NLRP3	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found