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pathway 3,076 words KG: ent-gene-961a77ee
Contents

APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chain

🔬 Protein Info
Gene Symbolent-gene-961a77ee
Chromosome21q21.3
FunctionAmyloid-beta Peptides
Synaptic formation and plasticityAPP is involved in neuronal development, synapse formation, and long-term potentiation
Metal homeostasisAPP binds copper and zinc ions, participating in metal transport
Cellular protectionActs as a scavenger receptor and provides neuroprotection under stress
Protein processingServes as a substrate for proteases generating functional fragments
KG Connections21 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

WikiPathwaysKEGGReactome

Related Hypotheses (41)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67TREM2-mediated microglial tau clearance enhancement
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60VCP-Mediated Autophagy Enhancement
Score: 0.59Extracellular Vesicle Biogenesis Modulation
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Aquaporin-4 Polarization Rescue
Score: 0.73
pg 1/3Next →

Related Analyses (30)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (30)

Plasma ATN biomarkers across AD continuum in Chilean cohort
clinical · proposed · Score: 0.95Adoptive transfer of TCRAβ-Tregs in AD mouse model
validation · proposed · Score: 0.90Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's diseas
validation · proposed · Score: 0.95Anti-ASC antibody intracerebroventricular injection in APP/P
validation · proposed · Score: 0.95

See Also (15)

ASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDigital Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDried Blood Spot Biomarker Test for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDTI Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesEEG Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses

Knowledge Graph (12 edges)

ent-gene-961a77ee has_risk_variant multiple
ent-gene-961a77ee participates_in_pathway R-HSA-933542
ent-gene-961a77ee participates_in_pathway R-HSA-879415
ent-gene-961a77ee participates_in_pathway R-HSA-977225
ent-gene-961a77ee participates_in_pathway R-HSA-9936686
ent-gene-961a77ee participates_in_pathway R-HSA-9936900
ent-gene-961a77ee participates_in_pathway R-HSA-3000178
ent-gene-961a77ee participates_in_pathway R-HSA-8862803
ent-gene-961a77ee participates_in_pathway R-HSA-9660826
ent-gene-961a77ee participates_in_pathway R-HSA-844456

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