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pathway 3,076 words KG: ent-gene-961a77ee
Contents

APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chain

🔬 Protein Info
Gene Symbolent-gene-961a77ee
Chromosome21q21.3
FunctionAmyloid-beta Peptides
Synaptic formation and plasticityAPP is involved in neuronal development, synapse formation, and long-term potentiation
Metal homeostasisAPP binds copper and zinc ions, participating in metal transport
Cellular protectionActs as a scavenger receptor and provides neuroprotection under stress
Protein processingServes as a substrate for proteases generating functional fragments
KG Connections21 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

WikiPathwaysKEGGReactome

Related Hypotheses (41)

Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.80Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64Glycosaminoglycan Template Disruption Approach
Score: 0.60HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73APOE Isoform Conversion Therapy
Score: 0.72TREM2-Dependent Microglial Senescence Transition
Score: 0.62
← Prevpg 2/3Next →

Related Analyses (30)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (30)

Plasma ATN biomarkers across AD continuum in Chilean cohort
clinical · proposed · Score: 0.95Adoptive transfer of TCRAβ-Tregs in AD mouse model
validation · proposed · Score: 0.90Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's diseas
validation · proposed · Score: 0.95Anti-ASC antibody intracerebroventricular injection in APP/P
validation · proposed · Score: 0.95

See Also (15)

ASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDigital Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDried Blood Spot Biomarker Test for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDTI Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesEEG Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses

Knowledge Graph (12 edges)

ent-gene-961a77ee has_risk_variant multiple
ent-gene-961a77ee participates_in_pathway R-HSA-933542
ent-gene-961a77ee participates_in_pathway R-HSA-879415
ent-gene-961a77ee participates_in_pathway R-HSA-977225
ent-gene-961a77ee participates_in_pathway R-HSA-9936686
ent-gene-961a77ee participates_in_pathway R-HSA-9936900
ent-gene-961a77ee participates_in_pathway R-HSA-3000178
ent-gene-961a77ee participates_in_pathway R-HSA-8862803
ent-gene-961a77ee participates_in_pathway R-HSA-9660826
ent-gene-961a77ee participates_in_pathway R-HSA-844456

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