Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MITOCHONDRIAL DAMAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MITOCHONDRIAL DAMAGE |
Knowledge base pages for this entity
graph TD
MITOCHONDRIAL_DAMAGE["MITOCHONDRIAL DAMAGE"]
MITOCHONDRIAL_DAMAGE -->|"causes"| mitochondrial_DNA_release["mitochondrial DNA release"]
MITOCHONDRIAL_DAMAGE -->|"activates"| PINK1["PINK1"]
MITOCHONDRIAL_DAMAGE -->|"causes"| Virtual_Hypoxia["Virtual Hypoxia"]
MITOCHONDRIAL_DAMAGE -->|"involved_in"| Hepatic_Encephalopathy["Hepatic Encephalopathy"]
MITOCHONDRIAL_DAMAGE -->|"activates"| NLRP3["NLRP3"]
GSDME["GSDME"] -->|"mediates"| MITOCHONDRIAL_DAMAGE
PDE4D_overexpression["PDE4D overexpression"] -->|"causes"| MITOCHONDRIAL_DAMAGE
BAK["BAK"] -->|"causes"| MITOCHONDRIAL_DAMAGE
Cisplatin["Cisplatin"] -->|"causes"| MITOCHONDRIAL_DAMAGE
CLU["CLU"] -->|"modulates"| MITOCHONDRIAL_DAMAGE
Mitophagy["Mitophagy"] -.protects against.-> MITOCHONDRIAL_DAMAGE
Oxidative_Stress["Oxidative Stress"] -->|"causes"| MITOCHONDRIAL_DAMAGE| Target | Relation | Type | Str |
|---|---|---|---|
| Oxidative Stress | contributes_to | process | 0.95 |
| Hk2-Pink1 Complex Formation | associated_with | mechanism | 0.91 |
| mitochondrial DNA release | causes | phenotype | 0.90 |
| PINK1 | activates | gene | 0.88 |
| Nlrp3 Inflammasome | activates | pathway | 0.88 |
| Virtual Hypoxia | causes | phenotype | 0.85 |
| Nlrp3 Inflammasome Signaling | activates | pathway | 0.85 |
| mitochondrial membrane potential loss | causes | phenotype | 0.85 |
| Amyotrophic Lateral Sclerosis | contributes_to | disease | 0.85 |
| Hepatic Encephalopathy | involved_in | disease | 0.80 |
| NLRP3 | activates | protein | 0.80 |
| Parkinson's Disease | contributes_to | disease | 0.80 |
| Amyotrophic Lateral Sclerosis | causes | disease | 0.80 |
| NLRP3 | associated_with | protein | 0.78 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GSDME | mediates | protein | 0.95 |
| PDE4D overexpression | causes | gene | 0.92 |
| pS65-Ub | biomarker_for | biomarker | 0.92 |
| Cisplatin | causes | drug | 0.90 |
| CLU | modulates | protein | 0.90 |
| PINK1 | associated_with | protein | 0.90 |
| Curcumin | associated_with | compound | 0.90 |
| WIF1 | protects_against | gene | 0.90 |
| CGAS | associated_with | gene | 0.90 |
| BAK | causes | protein | 0.90 |
| Contrast Media | causes | compound | 0.88 |
| CLU | inhibits | protein | 0.85 |
| ER Stress | causes | process | 0.85 |
| SOD1 | causes | gene | 0.85 |
| Mitophagy | protects_against | process | 0.85 |
| Oxidative Stress | causes | process | 0.85 |
| Aminoglycosides | causes | drug | 0.80 |
| BNIP3L | protects_against | protein | 0.80 |
| Hepatic Encephalopathy | involved_in | disease | 0.80 |
| GSDME | causes | gene | 0.80 |
| TDP-43 | causes | protein | 0.80 |
| TNF-α | causes | protein | 0.80 |
| Ginsenoside Rb1 | protects_against | drug | 0.70 |
| SOD1 | causes | gene | 0.70 |
| mTOR | causes | pathway | 0.70 |
| TARDBP | causes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||