concept

CISPLATIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CISPLATIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections

0Hypotheses

0Analyses

37Outgoing

25Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CISPLATIN
Key Genes/Proteins	AKT, CLU, BAX
Related Diseases	BREAST CANCER, LUNG CANCER, TUMOR MICROENVIRONMENT, DRUG RESISTANCE, TUMOR GROWTH

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CISPLATIN["CISPLATIN"]
    CISPLATIN -->|"treats"| Triple_Negative_Breast_Cancer["Triple-Negative Breast Cancer"]
    CISPLATIN -->|"causes"| Chemotherapy_Induced_Periphera["Chemotherapy-Induced Peripheral Neuropathy"]
    CISPLATIN -->|"causes"| acute_kidney_injury["acute kidney injury"]
    CISPLATIN -->|"causes"| Mitochondrial_Damage["Mitochondrial Damage"]
    CISPLATIN -->|"binds"| DNA["DNA"]
    CISPLATIN -->|"activates"| mitophagy["mitophagy"]
    CISPLATIN -->|"activates"| PACLITAXEL["PACLITAXEL"]
    CISPLATIN -->|"activates"| ROS["ROS"]
    CANCER["CANCER"] -->|"activates"| CISPLATIN
    BAX["BAX"] -->|"interacts"| CISPLATIN
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| CISPLATIN
    BREAST_CANCER["BREAST CANCER"] -->|"activates"| CISPLATIN

Outgoing (42)

Target	Relation	Type	Str
BREAST CANCER	treats	disease	0.65
LUNG CANCER	inhibits	disease	0.65
PACLITAXEL	activates	drug	0.50
AKT	associated_with	gene	0.50
CANCER	associated_with	disease	0.45
ROS	associated_with	phenotype	0.45
ISCHEMIA	associated_with	disease	0.45
MITOPHAGY	associated_with	phenotype	0.45
CLU	associated_with	gene	0.45
BAX	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
SOD1	associated_with	gene	0.45
DOCETAXEL	associated_with	drug	0.45
PACLITAXEL	associated_with	drug	0.45
NEUROPATHY	associated_with	disease	0.45
OXALIPLATIN	associated_with	drug	0.45
VINCRISTINE	associated_with	drug	0.45
MITOCHONDRIA	associated_with	phenotype	0.45
FIBROBLASTS	associated_with	cell_type	0.45
FERROPTOSIS	associated_with	phenotype	0.45
LUNG CANCER	associated_with	disease	0.45
HNRNPA1	associated_with	gene	0.45
ROS	activates	protein	0.35
MITOPHAGY	interacts_with	process	0.35
LC3	interacts_with	gene	0.35
ROS	inhibits	protein	0.35
FIBROBLASTS	activates	cell_type	0.35
SOD1	activates	gene	0.35
NF-KB	activates	gene	0.35
NEUROPATHY	activates	disease	0.35
ISCHEMIA	activates	disease	0.35
LUNG CANCER	activates	disease	0.35
FERROPTOSIS	activates	process	0.35
LONG NON-CODING RNA	activates	process	0.35
LUNG CANCER	therapeutic_target	disease	0.35
LONG NON-CODING RNA	regulates	process	0.35
PACLITAXEL	protects_against	drug	0.35

Incoming (27)

Source	Relation	Type	Str
TUMOR MICROENVIRONMENT	activates	phenotype	0.65
CARFILZOMIB	targets	drug	0.65
AKT	inhibits	gene	0.65
DRUG RESISTANCE	associated_with	phenotype	0.50
TUMOR GROWTH	associated_with	phenotype	0.50
PACLITAXEL	associated_with	drug	0.45
OXALIPLATIN	associated_with	drug	0.45
VINCRISTINE	associated_with	drug	0.45
BORTEZOMIB	associated_with	drug	0.45
NEUROPATHY	associated_with	disease	0.45
BREAST CANCER	associated_with	disease	0.45
FIBROBLASTS	associated_with	cell_type	0.45
LUNG CANCER	associated_with	disease	0.45
FERROPTOSIS	associated_with	phenotype	0.45
CANCER	associated_with	disease	0.45
BAX	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
5-FLUOROURACIL	associated_with	drug	0.45
TUMOR MICROENVIRONMENT	associated_with	phenotype	0.45
CANCER	activates	disease	0.35
BAX	interacts_with	gene	0.35
APOPTOSIS	inhibits	process	0.35
CANCER	inhibits	disease	0.35
BREAST CANCER	activates	disease	0.35
BREAST CANCER	therapeutic_target	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CISPLATIN

Understanding Entity Pages

Wiki Pages (20)

Charcot-Marie-Tooth Disease

FANCF Gene

Artemin Protein

fance

Section 164: Advanced Metal Chelation and Homeostasis in CBS/PSP

FANCA Gene

ngn1

LRP2 — Low Density Lipoprotein Receptor-Related Protein 2 (Megalin)

slc22a2

Area Postrema Neurons in Chemotherapy-Induced Nausea

DCLRE1A Gene

N-Acetylcysteine Therapy for Neurodegeneration

sarm1-programmed-axon-degeneration

HMGB1 Protein

sarm1-inhibitors-neurodegeneration

Cochlear Neurons

FANCL Protein

Inner Hair Cells