protein

BNIP3L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BNIP3L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1019Connections
0Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

BNIP3L is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 517 entities in the SciDEX knowledge graph.

View on Wiki →

🔬 Protein Info
Gene SymbolBNIP3L
Full NameBCL2 Interacting Protein 3 Like (NIX)
Chromosome8p21.2
FunctionMitochondrial recruitment: Being anchored to the mitochondrial outer membrane, BNIP3L clusters at sites of autophagosome initiation
Primary ExpressionCerebral cortex, Mitochondria, Substantia nigra
PathwaysAdaptive Immunity, Apoptosis, Autophagy, Epigenetic, Immune Response
UniProt IDO60238
NCBI Gene ID665
OMIM603588
GeneCardsBNIP3L
Human Protein AtlasBNIP3L
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
InteractionsNDP52, HIF1A, MAP1LC3B, GBA, FUNDC1, AMBRA1
KG Connections1016 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: BNIP3L — AlphaFold O60238 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

BNIP3L — BCL2 Interacting Protein 3 Like (NIX)

gene · 738 words

Mitochondrial Quality Control

mechanism · 5069 words

Autophagy Mechanisms

mechanism · 4866 words

Mitophagy Pathway in Neurodegeneration

mechanism · 4637 words

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

clinical · 4511 words

mitophagy-defect

mechanism · 3933 words

Pathway Diagram

flowchart TD
    BNIP3L(["BNIP3L"])
    Mitophagy["Mitophagy"]
    MITOPHAGY_RECEPTOR["MITOPHAGY RECEPTOR"]
    PROTEASOMES["PROTEASOMES"]
    mitophagy["mitophagy"]
    Damaged_Mitochondria("Damaged Mitochondria")
    Als["Als"]
    Proteasome["Proteasome"]
    Mitochondrial_Damage("Mitochondrial Damage")
    Autophagy["Autophagy"]
    MITOPHAGY(["MITOPHAGY"])
    NIX(["NIX"])
    Cancer["Cancer"]

    BNIP3L -->|"involved in"| Mitophagy
    BNIP3L -->|"associated with"| MITOPHAGY_RECEPTOR
    PROTEASOMES -.->|"degrades"| BNIP3L
    BNIP3L -->|"participates in"| mitophagy
    BNIP3L -->|"targets"| Damaged_Mitochondria
    BNIP3L -->|"mediates"| Mitophagy
    BNIP3L -->|"regulates"| Als
    Proteasome -.->|"degrades"| BNIP3L
    BNIP3L -->|"protects against"| Mitochondrial_Damage
    BNIP3L -->|"regulates"| Autophagy
    MITOPHAGY -->|"regulates"| BNIP3L
    NIX -->|"regulates"| BNIP3L
    BNIP3L -->|"regulates"| Cancer
    BNIP3L -->|"activates"| Mitophagy
    BNIP3L -->|"regulates"| Mitophagy

    style BNIP3L fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (665)

TargetRelationTypeStr
MITOPHAGY RECEPTORassociated_withreceptor0.95
Mitophagyinvolved_inprocess0.95
Damaged Mitochondriatargetsphenotype0.90
Mitophagy Deficiencyinvolved_inphenotype0.90
Cerebral Ischemiaprotects_againstdisease0.90

Incoming (354)

SourceRelationTypeStr
PROTEASOMESdegradesenzyme0.95
h-2a4e4ad2targets_genehypothesis0.90
MITOPHAGYregulatesgene0.80
NIXregulatesgene0.80
SQSTM1regulatesgene0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.450

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found