Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BNIP3L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BNIP3L is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 517 entities in the SciDEX knowledge graph.
| Gene Symbol | BNIP3L |
| Full Name | BCL2 Interacting Protein 3 Like (NIX) |
| Chromosome | 8p21.2 |
| Function | Mitochondrial recruitment: Being anchored to the mitochondrial outer membrane, BNIP3L clusters at sites of autophagosome initiation |
| Primary Expression | Cerebral cortex, Mitochondria, Substantia nigra |
| Pathways | Adaptive Immunity, Apoptosis, Autophagy, Epigenetic, Immune Response |
| UniProt ID | O60238 |
| NCBI Gene ID | 665 |
| OMIM | 603588 |
| GeneCards | BNIP3L |
| Human Protein Atlas | BNIP3L |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Interactions | NDP52, HIF1A, MAP1LC3B, GBA, FUNDC1, AMBRA1 |
| KG Connections | 1016 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
BNIP3L(["BNIP3L"])
Mitophagy["Mitophagy"]
MITOPHAGY_RECEPTOR["MITOPHAGY RECEPTOR"]
PROTEASOMES["PROTEASOMES"]
mitophagy["mitophagy"]
Damaged_Mitochondria("Damaged Mitochondria")
Als["Als"]
Proteasome["Proteasome"]
Mitochondrial_Damage("Mitochondrial Damage")
Autophagy["Autophagy"]
MITOPHAGY(["MITOPHAGY"])
NIX(["NIX"])
Cancer["Cancer"]
BNIP3L -->|"involved in"| Mitophagy
BNIP3L -->|"associated with"| MITOPHAGY_RECEPTOR
PROTEASOMES -.->|"degrades"| BNIP3L
BNIP3L -->|"participates in"| mitophagy
BNIP3L -->|"targets"| Damaged_Mitochondria
BNIP3L -->|"mediates"| Mitophagy
BNIP3L -->|"regulates"| Als
Proteasome -.->|"degrades"| BNIP3L
BNIP3L -->|"protects against"| Mitochondrial_Damage
BNIP3L -->|"regulates"| Autophagy
MITOPHAGY -->|"regulates"| BNIP3L
NIX -->|"regulates"| BNIP3L
BNIP3L -->|"regulates"| Cancer
BNIP3L -->|"activates"| Mitophagy
BNIP3L -->|"regulates"| Mitophagy
style BNIP3L fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| MITOPHAGY RECEPTOR | associated_with | receptor | 0.95 |
| Mitophagy | involved_in | process | 0.95 |
| Damaged Mitochondria | targets | phenotype | 0.90 |
| Mitophagy Deficiency | involved_in | phenotype | 0.90 |
| Cerebral Ischemia | protects_against | disease | 0.90 |
| mitophagy | participates_in | pathway | 0.90 |
| Mitophagy | mediates | process | 0.90 |
| Als | regulates | disease | 0.85 |
| Mitochondrial Damage | protects_against | process | 0.80 |
| Mitochondria | interacts_with | cell_type | 0.80 |
| autophagy pathway | participates_in | pathway | 0.80 |
| Autophagy | regulates | pathway | 0.80 |
| Cancer | regulates | disease | 0.75 |
| PARKIN | regulates | gene | 0.70 |
| Mitophagy | activates | pathway | 0.70 |
| Mitophagy | regulates | pathway | 0.70 |
| Alzheimer's disease | regulates | disease | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| ubiquitin-proteasome | participates_in | pathway | 0.70 |
| apoptosis pathway | participates_in | pathway | 0.70 |
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Ischemia | associated_with | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cardiovascular | inhibits | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | interacts_with | disease | 0.65 |
| Cardiovascular | therapeutic_target | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Ftd | interacts_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Heart Failure | regulates | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Heart Failure | inhibits | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Cardiac | activates | disease | 0.65 |
| Ischemia | activates | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PROTEASOMES | degrades | enzyme | 0.95 |
| h-2a4e4ad2 | targets_gene | hypothesis | 0.90 |
| MITOPHAGY | regulates | gene | 0.80 |
| NIX | regulates | gene | 0.80 |
| SQSTM1 | regulates | gene | 0.70 |
| P62 | regulates | gene | 0.70 |
| MITOCHONDRIA | regulates | gene | 0.70 |
| MITOCHONDRIA | associated_with | gene | 0.70 |
| CANCER | regulates | gene | 0.70 |
| AUTOPHAGY | regulates | gene | 0.70 |
| CAT | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| PEX3 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| BCL2 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
| BNIP3 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.450
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||