Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about mitochondrial_biogenesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| perforant_path_protection | promotes | phenotype | 0.80 |
| neurodegeneration | protects_against | disease | 0.80 |
| oral_cancer | activates | disease | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NNMT | disrupts | gene | 0.80 |
| PGC1A_protein | activates | protein | 0.80 |
| energy_sensing_pathway | activates | pathway | 0.80 |
| PPARGC1A | master_regulator | gene | 0.80 |
| PPARGC1A | activates | gene | 0.72 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neur | 0.435 | translational neuroscience | Which metabolic biomarkers can distingui |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.484
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Alterations in mRNA level of proteins related to redox state and mitochondria in [PMID:39529534] | Żulińska S, Wencel PL, Czubowicz K, Stro | Folia Neuropathol | 2024 | 0 |
| 2,2',4,4'-Tetrabromodiphenyl ether disrupts spermatogenesis in mice by interferi [PMID:35238255] | Huang S, Xia J, Zhang X, Zhou T, Wang J | Toxicol Ind Health | 2022 | 0 |
| Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1. [PMID:31026811] | Yang W, Yan H, Pan Q, Shen JZ, Zhou F et | J Endocrinol | 2019 | 0 |