gene

PGC1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGC1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

203Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

1Experiments

13Debates

Summary

PGC1A is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, implicated in. Associated with Aging, Als, Alzheimer. Connected to 88 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PGC1A
Full Name	PPARG Coactivator 1 Alpha
Chromosome	4p15.1
Target Class	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Circuits
Primary Expression	neurons, astrocytes, and oligodendrocytes [18] - Regulation: Highly responsive to environmental and h
Druggability	Undruggable (0.23)
Molecular Weight	91 kDa
Pathways	AMPK, MAPK pathway
UniProt ID	Q9UBX3
NCBI Gene ID	10887
Ensembl ID	ENSG00000100739
GeneCards	PGC1A
Human Protein Atlas	PGC1A
Associated Diseases	Aging, Als, Breast Cancer, Cancer, Huntington's disease, neurodegeneration
Interactions	ACETYL-COA, AGING, AMPK, AND, APOE, ATP
SciDEX Target	View Target Profile
KG Connections	203 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PGC1A — AlphaFold Q9UBX3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PGC1A Gene

gene · 1324 words

→

PGC1A Protein

protein · 727 words

→

Pathway Diagram

graph TD
    PGC1A["PGC1A"]
    PGC1A -->|"activates"| NRF1["NRF1"]
    PGC1A -->|"activates"| NRF2["NRF2"]
    PGC1A -->|"regulates"| MITOCHONDRIAL_BIOGENESIS["MITOCHONDRIAL_BIOGENESIS"]
    PGC1A -->|"regulates"| MITOCHONDRIAL_ACTIVITY["MITOCHONDRIAL_ACTIVITY"]
    PGC1A -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE_PHOSPHORYLATION"]
    PGC1A -->|"activates"| METASTASIS["METASTASIS"]
    PGC1A -->|"activates"| Diabetes["Diabetes"]
    PGC1A -->|"activates"| Cardiac["Cardiac"]
    PGC1A -->|"activates"| Heart_Failure["Heart Failure"]
    PPARGC1A["PPARGC1A"] -->|"encodes"| PGC1A
    AMPK["AMPK"] -->|"phosphorylates"| PGC1A
    LC3B["LC3B"] -->|"activates"| PGC1A
    PER["PER"] -->|"expressed in"| PGC1A
    FASN["FASN"] -->|"activates"| PGC1A
    NFKBIA["NFKBIA"] -->|"activates"| PGC1A
    AGING["AGING"] -->|"interacts"| PGC1A
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"interacts"| PGC1A

Outgoing (144)

Target	Relation	Type	Str
mitochondrial biogenesis	promotes	process	0.95
Mitochondrial Biogenesis	regulates	process	0.95
Inflammatory Cytokines	regulates	compound	0.90
PARVALBUMIN INTERNEURONS	regulates	entity	0.90
Amyloid-Beta	downregulates	protein	0.90
NRF	interacts_with	protein	0.85
Phosphorylation	involved_in	mechanism	0.85
MITOCHONDRIA	regulates	cell_type	0.85
Alzheimer's Disease	protects_against	disease	0.85
SYNAPTIC PLASTICITY	regulates	entity	0.85
Myocardial Ischemia-Reperfusion Injury	regulates	disease	0.80
Myocardial Ischemia-Reperfusion Injury	protects_against	disease	0.75
NRF1	activates	protein	0.72
OXIDATIVE_PHOSPHORYLATION	activates	phenotype	0.72
NRF2	activates	protein	0.72
MITOCHONDRIAL_BIOGENESIS	regulates	pathway	0.72
MITOCHONDRIAL_ACTIVITY	regulates	phenotype	0.72
MITOCHONDRIAL_BIOGENESIS	activates	phenotype	0.72
METASTASIS	activates	phenotype	0.72
mitochondrial biogenesis	regulates	pathway	0.70
Myocardial Ischemia-Reperfusion Injury	involved_in	disease	0.70
NEURON	activates	cell_type	0.70
mitochondrial function	regulates	mechanism	0.70
NRF2	causes	gene	0.70
Aging	implicated_in	disease	0.65
Cancer	implicated_in	disease	0.65
Tumor	implicated_in	disease	0.65
Heart Failure	activates	disease	0.65
Cardiac	activates	disease	0.65
Diabetes	activates	disease	0.65
Retinal Degeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Breast Cancer	implicated_in	disease	0.65
Als	implicated_in	disease	0.65
Als	expressed_in	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Huntington	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Cardiovascular	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Macular Degeneration	activates	disease	0.65
Aging	activates	disease	0.65
Als	inhibits	disease	0.65
Cardiomyopathy	therapeutic_target	disease	0.65

Incoming (59)

Source	Relation	Type	Str
PPARGC1A	encodes	gene	0.95
SIRT1	activates	gene	0.90
PPARG	interacts_with	entity	0.90
h-827a821b	targets_gene	hypothesis	0.90
AMPK	phosphorylates	protein	0.90
GSK3B	regulates	gene	0.85
SIRT1	regulates	protein	0.85
SDA-2026-04-02-gap-crispr-neurodegeneration-20260402	targets	analysis	0.80
SIRT1	modifies	gene	0.70
IL6	inhibits	gene	0.70
AMPK	stabilizes	gene	0.65
LDH	activates	gene	0.60
AMPK	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NRF1	implicated_in	gene	0.60
INFLAMMATION	regulates	gene	0.60
AND	activates	gene	0.60
STAT3	activates	gene	0.60
AGING	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
AGING	implicated_in	gene	0.60
PER	expressed_in	gene	0.60
RNA	activates	gene	0.60
NFKBIA	activates	gene	0.60
LC3B	activates	gene	0.60
FASN	activates	gene	0.60
SIRT3	associated_with	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
AGING	activates	gene	0.60
GENES	inhibits	gene	0.60
FERROPTOSIS	activates	gene	0.60
FNDC5	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
HK2	activates	gene	0.60
HK2	expressed_in	gene	0.60
EXERCISE	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
NRF2	activates	gene	0.55
NRF1	activates	gene	0.55
FOXO3	activates	gene	0.55
ATP	activates	gene	0.55
HUNTINGTON	associated_with	disease	0.50
PARKINSON'S DISEASE	associated_with	disease	0.50
PARKINSON	associated_with	disease	0.50
SIRT1	interacts_with	gene	0.44
FOXO3	interacts_with	gene	0.44
mitochondrial biogenesis genes	interacts_with	gene	0.44
NURR1	co_discussed	gene	0.40
FOXO3	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SIRT1 Activation Couples Mitochondrial Biogenesis to Ferropt	0.824	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Irisin effects on osteogenic differentiation in mesenchymal stem cells	exploratory	bone fracture	0.900	0.00	mouse bone mesenchymal stem ce	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (13)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning PGC1A in their description or question text

No additional research found

PGC1A

Understanding Entity Pages

Summary

Wiki Pages (2)

PGC1A Gene

PGC1A Protein

Pathway Diagram

Outgoing (144)

Incoming (59)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Epigenetic reprogramming in aging neurons

Senescent cell clearance as neurodegeneration therapy

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Experiments (1)

Related Papers (5)

Debates (13)

Extended debate: Metabolic Reprogramming to Reverse Senescence

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

Hypothesis debate: SASP Modulation Rather Than Cell Elimination

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

Epigenetic reprogramming in aging neurons

Related Research