Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about nnmt: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NNMT |
| Full Name | Nicotinamide N-methyltransferase |
| Chromosome | 11q23.2 |
| Protein Type | Enzyme |
| Function | NNMT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing N-methylnicotinamide (MNAM) and S-adenosyl-L-homocysteine (SAH). |
| Primary Expression | various brain regions: - Cerebral cortex - Hippocampus - Substantia nigra - [Cerebellum](/brain |
| Molecular Weight | 30 kDa |
| UniProt ID | P40261 |
| NCBI Gene ID | 4837 |
| Ensembl ID | ENSG00000166741 |
| GeneCards | NNMT |
| Human Protein Atlas | NNMT |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
NNMT["NNMT"] -->|"phosphorylates"| PI3K["PI3K"]
NNMT["NNMT"] -->|"activates"| PI3K["PI3K"]
NNMT["NNMT"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
NNMT["NNMT"] -->|"participates in"| oxidative_stress_response["oxidative stress response"]
NNMT["NNMT"] -->|"participates in"| mitochondrial_function["mitochondrial function"]
NNMT["NNMT"] -->|"regulates"| SIRT1["SIRT1"]
NNMT["NNMT"] -->|"participates in"| epigenetic_regulation["epigenetic regulation"]
NNMT["NNMT"] -->|"causes"| neuroinflammation["neuroinflammation"]
NNMT["NNMT"] -.->|"inhibits"| RNA["RNA"]
AKT["AKT"] -->|"phosphorylates"| NNMT["NNMT"]
ERBB4["ERBB4"] -->|"phosphorylates"| NNMT["NNMT"]
AKT["AKT"] -->|"activates"| NNMT["NNMT"]
ERBB4["ERBB4"] -->|"activates"| NNMT["NNMT"]
NAD["NAD"] -->|"regulates"| NNMT["NNMT"]
NAD["NAD"] -->|"causes"| NNMT["NNMT"]
NAD["NAD"] -.->|"inhibits"| NNMT["NNMT"]
DNA["DNA"] -->|"regulates"| NNMT["NNMT"]
DNA["DNA"] -->|"expressed in"| NNMT["NNMT"]
style NNMT fill:#4a1a6b,stroke:#333,color:#e0e0e0
style PI3K fill:#4a1a6b,stroke:#333,color:#e0e0e0
style PI3K_AKT_mTOR_signaling fill:#1b5e20,stroke:#333,color:#e0e0e0
style oxidative_stress_response fill:#1b5e20,stroke:#333,color:#e0e0e0
style mitochondrial_function fill:#1b5e20,stroke:#333,color:#e0e0e0
style SIRT1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style epigenetic_regulation fill:#1b5e20,stroke:#333,color:#e0e0e0
style neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style RNA fill:#4a1a6b,stroke:#333,color:#e0e0e0
style AKT fill:#4a1a6b,stroke:#333,color:#e0e0e0
style ERBB4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style NAD fill:#4a1a6b,stroke:#333,color:#e0e0e0
style DNA fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegenerative_disorders | implicated_in | disease | 0.80 |
| Alzheimer's_disease | implicated_in | disease | 0.80 |
| Parkinson's_disease | implicated_in | disease | 0.80 |
| Huntington's_disease | implicated_in | disease | 0.80 |
| DNA_methylation | regulates | biological_process | 0.80 |
| histone_modification | regulates | biological_process | 0.80 |
| NAD+_synthesis | disrupts | biological_process | 0.80 |
| homocysteine_metabolism | disrupts | biological_process | 0.80 |
| mitochondrial_dysfunction | causes | phenotype | 0.80 |
| energy_metabolism | impairs | biological_process | 0.80 |
| oxidative_stress | causes | biological_process | 0.80 |
| protein_aggregation | causes | biological_process | 0.80 |
| tau | causes_aggregation_of | protein | 0.80 |
| DNA_methyltransferases | inhibits | protein | 0.80 |
| histone_methyltransferases | inhibits | protein | 0.80 |
| SIRT1 | inhibits | protein | 0.80 |
| mitochondrial_biogenesis | disrupts | biological_process | 0.80 |
| Aβ | causes_aggregation_of | protein | 0.80 |
| alpha-synuclein | causes_aggregation_of | protein | 0.80 |
| PI3K | phosphorylates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| SIRT1 | regulates | gene | 0.60 |
| neuroinflammation | causes | disease | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| mitochondrial function | participates_in | pathway | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.60 |
| RNA | inhibits | gene | 0.60 |
| macrophages | expressed_in | cell_type | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| benchmark_ot_ad_answer_key:NNMT | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||