gene

nnmt

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about nnmt: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections
0Hypotheses
0Analyses
31Outgoing
11Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolNNMT
Full NameNicotinamide N-methyltransferase
Chromosome11q23.2
Protein TypeEnzyme
FunctionNNMT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing N-methylnicotinamide (MNAM) and S-adenosyl-L-homocysteine (SAH).
Primary Expressionvarious brain regions: - Cerebral cortex - Hippocampus - Substantia nigra - [Cerebellum](/brain
Molecular Weight30 kDa
UniProt IDP40261
NCBI Gene ID4837
Ensembl IDENSG00000166741
GeneCardsNNMT
Human Protein AtlasNNMT
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: nnmt — AlphaFold P40261 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

NNMT Gene

gene · 2736 words

Homocysteine Neurotoxicity and Neurodegeneration

mechanism · 2433 words

Mitochondrial Dysfunction in Dopaminergic Neurons

cell · 1220 words

NNMT Protein

protein · 535 words

Proteins

index · 296 words

Pathway Diagram

flowchart TD
    NNMT["NNMT"] -->|"phosphorylates"| PI3K["PI3K"]
    NNMT["NNMT"] -->|"activates"| PI3K["PI3K"]
    NNMT["NNMT"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    NNMT["NNMT"] -->|"participates in"| oxidative_stress_response["oxidative stress response"]
    NNMT["NNMT"] -->|"participates in"| mitochondrial_function["mitochondrial function"]
    NNMT["NNMT"] -->|"regulates"| SIRT1["SIRT1"]
    NNMT["NNMT"] -->|"participates in"| epigenetic_regulation["epigenetic regulation"]
    NNMT["NNMT"] -->|"causes"| neuroinflammation["neuroinflammation"]
    NNMT["NNMT"] -.->|"inhibits"| RNA["RNA"]
    AKT["AKT"] -->|"phosphorylates"| NNMT["NNMT"]
    ERBB4["ERBB4"] -->|"phosphorylates"| NNMT["NNMT"]
    AKT["AKT"] -->|"activates"| NNMT["NNMT"]
    ERBB4["ERBB4"] -->|"activates"| NNMT["NNMT"]
    NAD["NAD"] -->|"regulates"| NNMT["NNMT"]
    NAD["NAD"] -->|"causes"| NNMT["NNMT"]
    NAD["NAD"] -.->|"inhibits"| NNMT["NNMT"]
    DNA["DNA"] -->|"regulates"| NNMT["NNMT"]
    DNA["DNA"] -->|"expressed in"| NNMT["NNMT"]
    style NNMT fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style PI3K fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style PI3K_AKT_mTOR_signaling fill:#1b5e20,stroke:#333,color:#e0e0e0
    style oxidative_stress_response fill:#1b5e20,stroke:#333,color:#e0e0e0
    style mitochondrial_function fill:#1b5e20,stroke:#333,color:#e0e0e0
    style SIRT1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style epigenetic_regulation fill:#1b5e20,stroke:#333,color:#e0e0e0
    style neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style RNA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style AKT fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ERBB4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NAD fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style DNA fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (31)

TargetRelationTypeStr
neurodegenerative_disordersimplicated_indisease0.80
Alzheimer's_diseaseimplicated_indisease0.80
Parkinson's_diseaseimplicated_indisease0.80
Huntington's_diseaseimplicated_indisease0.80
DNA_methylationregulatesbiological_process0.80

Incoming (11)

SourceRelationTypeStr
AKTphosphorylatesgene0.60
ERBB4phosphorylatesgene0.60
AKTactivatesgene0.60
ERBB4activatesgene0.60
NADregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found