concept

PERIODONTITIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERIODONTITIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

26Outgoing

19Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PERIODONTITIS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PERIODONTITIS["PERIODONTITIS"]
    PERIODONTITIS -->|"causes"| Systemic_Inflammation["Systemic Inflammation"]
    PERIODONTITIS -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    PERIODONTITIS -->|"risk_factor_for"| Parkinson_s_Disease["Parkinson's Disease"]
    PERIODONTITIS -->|"risk_factor_for"| Multiple_Sclerosis["Multiple Sclerosis"]
    PERIODONTITIS -->|"risk_factor_for"| Alzheimer_s_Disease_Dementia["Alzheimer's Disease Dementia"]
    PERIODONTITIS -->|"risk_factor_for"| Alzheimer_s_Disease_Mortality["Alzheimer's Disease Mortality"]
    PERIODONTITIS -->|"activates"| neurodegeneration["neurodegeneration"]
    Diabetes["Diabetes"] -->|"risk_factor_for"| PERIODONTITIS
    Inflammatory_Process["Inflammatory Process"] -->|"involved_in"| PERIODONTITIS
    Tetrathiomolybdate["Tetrathiomolybdate"] -->|"treats"| PERIODONTITIS
    Macrophages["Macrophages"] -->|"involved_in"| PERIODONTITIS
    Impaired_Autophagosome_Lysosom["Impaired Autophagosome-Lysosome Fusion"] -->|"contributes to"| PERIODONTITIS
    USP4["USP4"] -.protects against.-> PERIODONTITIS
    Cuproptosis["Cuproptosis"] -->|"contributes to"| PERIODONTITIS

Outgoing (26)

Target	Relation	Type	Str
Systemic Inflammation	causes	process	0.95
Tooth Supporting Structures	associated_with	cell_type	0.95
Neuroinflammation	causes	process	0.95
Inflammation	causes	process	0.95
ALZHEIMER'S DISEASE	contributes_to	disease	0.90
Alzheimer's Disease Dementia	risk_factor_for	disease	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
Parkinson's Disease	risk_factor_for	disease	0.85
Multiple Sclerosis	risk_factor_for	disease	0.85
PARKINSON'S DISEASE	risk_factor_for	disease	0.85
Alzheimer'S Disease	risk_factor_for	disease	0.85
All-Cause Dementia	associated_with	disease	0.80
Systemic Illnesses	associated_with	phenotype	0.80
Alzheimer'S Disease	correlates_with	disease	0.80
Alzheimer'S Disease	associated_with	disease	0.80
Alzheimer's Disease	correlates_with	disease	0.78
Alzheimer's Disease Mortality	risk_factor_for	phenotype	0.75
Dementia	associated_with	disease	0.75
neurodegeneration	activates	process	0.70
Oral squamous cell carcinoma	associated_with	disease	0.70
Colorectal cancer	associated_with	disease	0.70
Breast cancer	associated_with	disease	0.70
Gastrointestinal cancers	associated_with	disease	0.70
Inflammatory bowel disease	associated_with	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
Alzheimer's disease	biomarker_for	disease	0.70

Incoming (19)

Source	Relation	Type	Str
Diabetes	associated_with	disease	0.95
USP4 Depletion	associated_with	mechanism	0.92
Diabetes	risk_factor_for	disease	0.92
Inflammatory Process	involved_in	process	0.90
Tetrathiomolybdate	treats	drug	0.90
Macrophages	involved_in	cell_type	0.90
RAB7A	associated_with	protein	0.90
Impaired Autophagosome-Lysosome Fusion	contributes_to	phenotype	0.90
Diabetes	causes	disease	0.88
Cuproptosis	contributes_to	process	0.85
CHEMR23	implicated_in	receptor	0.85
USP4	protects_against	gene	0.85
Autophagy	associated_with	process	0.85
USP4 reduction	promotes	process	0.80
RAB7A	regulates	protein	0.80
Inflammation	involved_in	process	0.80
AUTOPHAGY	aggravates	process	0.80
CHEMR23	implicated_in	gene	0.75
IFNG	implicated_in	protein	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PERIODONTITIS

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

TREM2 Mechanism Hub

williams-syndrome

rankings

Infectious Triggers in Alzheimer's Disease

HPA Axis Dysfunction in Neurodegeneration

Neuroinflammation in Alzheimer's Disease

viral-post-infectious-als

Microbiome-Gut-Brain Axis in Alzheimer's Disease: Knowledge Gap

LHP588: P. gingivalis Targeting for Alzheimer's Disease (NCT06847321)

psp-oral-health-dental-manifestations

amyloid-cascade-hypothesis

Chief Sensory Trigeminal Nucleus

Infectious Etiology Hypotheses in Alzheimer's Disease

Section 253: Respiratory Function and Dysphagia Therapy in CBS/PSP

Dental Health and Oral Microbiome in Neurodegeneration

evidence-contradictions-synthesis

KDM4B (Lysine Demethylase 4B)