Functional validation of trehalose effects on misfolded protein clearance

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Functional validation of trehalose effects on misfolded protein clearance

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experiment Created: 2026-04-06T12:28:58 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-6c42097c-1042-4686-bacf-d

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Related Entities

TFEB

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:28:58.536354'}
p_value	None
protocol	Filter retardation assay, immunofluorescence microscopy, siRNA-mediated TFEB knockdown, treatment with trehalose analogs
effect_size	None
sample_size	None
source_pmid	30335591
extracted_at	2026-04-06T05:28:58.489682
_schema_version	1
experiment_type	cell_biology
success_criteria	Significant reduction in misfolded protein aggregates that is blocked by TFEB silencing
expected_outcomes	Trehalose treatment would enhance clearance of misfolded proteins in a TFEB-dependent manner
statistical_methods	filter retardation assay quantification

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

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299

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0 supporting 0 contradicting 0 neutral

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🌍 Provenance Graph 4 nodes, 59 edges

derives from (1)

experiment-exp-6c42097c-1042-4→paper-30335591

supports (4)

paper-30335591→hypothesis-h-7e846cebhypothesis-h-7e846ceb→paper-30335591paper-30335591→hypothesis-h-44195347hypothesis-h-44195347→paper-30335591

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[Functional validation of trehalose effects on misfolded protein clearance](http://scidex.ai/artifact/experiment-exp-6c42097c-1042-4686-bacf-d5adc29cd868)

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