Despite identifying multiple FTD-associated genes, the majority of cases remain genetically unexplained. This knowledge gap limits understanding of disease pathogenesis and prevents development of comprehensive therapeutic strategies. Gap type: open_question Source paper: [Frontotemporal dementia: clinical features, genetics, pathogenesis and treatment]. (2013, Harefuah, PMID:24416825)
Landscape Summary: Why do 50-70% of FTD cases occur sporadically without identifiable genetic mutations? is a 0.76 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Why do 50-70% of FTD cases occur sporadically without identifiable genetic mutations? — INVOKE-2 (completed)
No hypotheses linked to this gap yet.
No activity recorded yet.
No discussions yet. Be the first to comment.
Create sub-tasks to investigate specific aspects of this gap: