gene 1,920 words KG: FUS 2026-03-24
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

FUS — Fused in Sarcoma

🧬 Gene Info
Gene SymbolFUS
Full NameFused in Sarcoma
Chromosome16p11.2
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionMotor cortex, Spinal cord, Nucleus (widespread)
PathwaysBlood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43
UniProt IDSearch UniProt
NCBI Gene ID2521
Ensembl IDENSG00000089280
OMIM137070
GeneCardsFUS
Human Protein AtlasFUS
Associated DiseasesAD, ALI, ALS, AMI, Aging
Known Drugs/CompoundsAntisense Oligonucleotide, ADUCANUMAB, RNA oligonucleotides, Rna Oligonucleotides
InteractionsTARDBP, LC3, ACTB, G3BP1, BCL2, C9ORF72
SciDEX HypothesesASO-Mediated Exon Skipping to Restore FUS-TAZ Chap
KG Connections1482 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (11)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (4)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40

See Also (8)

Aducanumab (Aduhelm)
therapeutic · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
ADNP Gene
gene · KG edge: protects_against
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

FUS co_discussed LC3
FUS co_discussed P62
FUS co_discussed TARDBP
FUS co_discussed PROTEOSTASIS
FUS co_discussed TDP-43
FUS activates NBR1
FUS activates NDP52
FUS activates OPTINEURIN
FUS activates OPTN
FUS activates SMCR8