gene 3,256 words KG: UBQLN2
Contents

UBQLN2 — Ubiquilin 2

🧬 Gene Info
Gene SymbolUBQLN2
Full NameUbiquilin 2
ChromosomeXp11.21
Protein FamilyUbiquilin family
FunctionContains disease-causing mutations (P497H, P506T)
Primary ExpressionMotor cortex, Spinal cord, Hippocampus
Subcellular LocalizationCytoplasm, nucleus
Molecular Weight66 kDa
Amino Acids600 aa
Exons11
PathwaysProtein Degradation
UniProt IDQ9R0R5
NCBI Gene ID29978
Ensembl IDENSG00000188021
OMIM300264
GeneCardsUBQLN2
Human Protein AtlasUBQLN2
Associated DiseasesALS, Amyotrophic Lateral Sclerosis, FTLD, Ms, NEURODEGENERATION
InteractionsHSP70, UNC5B, TIA1, HSPA1B, TDP-43, VAPB
KG Connections189 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
OPTN — Optineurin
gene · KG edge: associated_with
Genes
index · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: associated_with

Knowledge Graph (12 edges)

UBQLN2 activates PROTEIN_DEGRADATION
UBQLN2 associated_with OPTN
UBQLN2 associated_with GAIN
UBQLN2 associated_with C9ORF72
UBQLN2 interacts_with HSP70
UBQLN2 interacts_with UNC5B
UBQLN2 associated_with UBIQUITIN
UBQLN2 involved_in Protein Degradation
UBQLN2 activates TIA1
UBQLN2 activates HSPA1B