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Opposing patterns of blood-brain barrier permeability and Alzheimer's disease biomarkers across APOE genotype.
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Opposing patterns of blood-brain barrier permeability and Alzheimer's disease biomarkers across APOE genotype.
Bernocchi Francesca; Bonomi Chiara Giuseppina; Poli Martina; Di Donna Martina Gaia; Terrinoni Alessandro; Motta Caterina; Martorana Alessandro
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
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Abstract
APOE is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD), influencing both proteinopathies and cerebrovascular integrity. While the ε4 allele is well studied, the role of ε2—particularly in relation to blood-brain barrier (BBB) permeability—remains underexplored. To investigate the association between APOE genotype, BBB permeability, and AD pathology in a large cohort of biomarker-confirmed AD patients. We analyzed data from 895 patients with a CSF-based diagnosis of AD. A...
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