PITX3

Score: 0.273 Price: $0.27 Undruggable Druggability Status: active Wiki: PITX3 Gene

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🔮 PITX3 — AlphaFold O15360 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.20

Clinical Stage

Preclinical

Target Class

Signaling Protein

Safety

0.30

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.30

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR

Known Drugs:

No known drugs targeting this protein

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: O15360

🔮 Predicted Protein Structure (AlphaFold)

🔮 PITX3 — AlphaFold O15360 Click to expand interactive 3D viewer

AI-predicted structure from AlphaFold EBI | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

Open full viewer

AlphaFold predicted structure available for O15360

View AlphaFold Structure

Linked Hypotheses (0)

No linked hypotheses

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

activates (2)

NOXA → PITX3

PITX3 → BCL2

co discussed (17)

Cell-type-specific essential genes → PITX3

APOE regulatory regions → PITX3

NURR1 → PITX3

FOXO3 → PITX3

PGC1A → PITX3

...and 12 more

expressed in (1)

BAX → PITX3

Debate History (0)

No debates yet