PITX3

Score: 0.273 Price: $0.27 Undruggable Druggability Status: active Wiki: PITX3 Gene

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🔮 PITX3 — AlphaFold O15360 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.20

Clinical Stage

Preclinical

Target Class

Signaling Protein

Safety

0.30

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.30

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR

Known Drugs:

No known drugs targeting this protein

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: O15360

🔮 Predicted Protein Structure (AlphaFold)

🔮 PITX3 — AlphaFold O15360 Click to expand interactive 3D viewer

AI-predicted structure from AlphaFold EBI | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for O15360

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Linked Hypotheses (0)

No linked hypotheses

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

activates (2)

NOXA→PITX3PITX3→BCL2

co discussed (17)

Cell-type-specific essential genes→PITX3APOE regulatory regions→PITX3NURR1→PITX3FOXO3→PITX3PGC1A→PITX3

▸ Show 12 more

BDNF→PITX3LDLR→PITX3HTT→PITX3SIRT1→PITX3APOE→PITX3repeat-containing transcripts→PITX3PITX3→DMPKPITX3→synaptic plasticity genesPITX3→CREB1PITX3→HMGCRPITX3→mitochondrial biogenesis genesneuronal identity transcription factors→PITX3

expressed in (1)

BAX→PITX3

Debate History (1)

Should PITX3 (PITX3) be prioritized as a therapeutic target for neurodegeneratio2026-04-26