| Gene Symbol | HMGCR |
| Full Name | 3-Hydroxy-3-Methylglutaryl-CoA Reductase |
| Chromosome | 5 |
| Function | HMGCR plays a critical role in cholesterol metabolism, which is intimately connected to Alzheimer's disease pathogenesis through multiple mechanisms: |
| Pathways | Amyloid, Autophagy, Cholesterol, Cholesterol Metabolism, Lipid Metabolism |
| UniProt ID | [P04035](https://www.uniprot.org/uniprotkb/P04035/entry) |
| Ensembl ID | ENSG00000013113 |
| GeneCards | HMGCR |
| Human Protein Atlas | HMGCR |
| Associated Diseases | AD, Als, Alzheimer, Alzheimer disease, Alzheimer's disease |
| Known Drugs/Compounds | 25-Hydroxycholesterol, SIMVASTATIN, statins |
| Interactions | A2M, ABCA1, ACSL4, AGING, Akt, AKT |
| SciDEX Hypotheses | Membrane Lipid Composition Therapeutic Modulation Membrane Lipid Raft Reorganization Therapy |
| KG Connections | 814 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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