| Gene Symbol | SIRT1 |
| Chromosome | 10q21.3<br> |
| Target Class | Epigenetic Regulator |
| Function | SIRT1 uses NAD+ as a cofactor, linking its activity to cellular energy status and metabolic health. |
| Mechanism of Action | SIRT1 activation via NAD+ precursors or allosteric activators deacetylates tau (reducing aggregation), enhances mitophagy, and restores circadian gene expression |
| Druggability | High (0.80) |
| Clinical Stage | Phase II |
| Pathways | Akt, Ampk Signaling, Angiogenesis, Apoptosis, Autophagy |
| UniProt ID | Q96EB6 |
| NCBI Gene ID | 23411 |
| Ensembl ID | ENSG00000096717 |
| GeneCards | SIRT1 |
| Human Protein Atlas | SIRT1 |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, APOPTOSIS, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, METFORMIN, QBA, DSS, resveratrol, QGJZF |
| Interactions | DNM1L, PRKAA1, KDM6B, LC3, RPTOR, PRKAA2 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Nutrient-Sensing Epigenetic Circuit Reactivation SIRT1-Mediated Reversal of TREM2-Dependent Microgl Astrocyte Metabolic Memory Reprogramming |
| KG Connections | 2938 knowledge graph edges |
| Databases | GeneCardsHPASTRING |